Protonix and Tic - a phase IV clinical study of FDA data


Tic is found among people who take Protonix, especially for people who are female, 60+ old.

The phase IV clinical study analyzes which people take Protonix and have Tic. It is created by eHealthMe based on reports of 124,840 people who have side effects when taking Protonix from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Nov, 24, 2022

124,840 people reported to have side effects when taking Protonix.
Among them, 9 people (0.01%) have Tic.

What is Protonix?

Protonix has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 127,247 Protonix users for its effectiveness, alternative drugs and more.

What is Tic?

Tic (a sudden, repetitive, nonrhythmic motor movement or vocalization involving discrete muscle groups) is found to be associated with 997 drugs and 620 conditions by eHealthMe.

Number of Protonix and Tic reports submitted per year:

Could Protonix cause Tic?

Gender of people who have Tic when taking Protonix *:

  • female: 66.67 %
  • male: 33.33 %

Age of people who have Tic when taking Protonix *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 12.5 %
  • 20-29: 0.0 %
  • 30-39: 25.0 %
  • 40-49: 0.0 %
  • 50-59: 25.0 %
  • 60+: 37.5 %

Common drugs people take besides Protonix *:

  1. Metoclopramide: 4 people, 44.44%
  2. Hydrochlorothiazide: 3 people, 33.33%
  3. Premarin: 2 people, 22.22%
  4. Bentyl: 2 people, 22.22%
  5. Levaquin: 2 people, 22.22%
  6. Furosemide: 2 people, 22.22%
  7. Nasonex: 2 people, 22.22%
  8. Nexium: 2 people, 22.22%
  9. Norvasc: 2 people, 22.22%
  10. Paxil: 2 people, 22.22%

Common side effects people have besides Tic *:

  1. High Blood Pressure: 4 people, 44.44%
  2. Tardive Dyskinesia (a disorder that involves involuntary movements): 4 people, 44.44%
  3. Injury: 3 people, 33.33%
  4. Breathing Difficulty: 3 people, 33.33%
  5. Pain: 3 people, 33.33%
  6. Emotional Distress: 2 people, 22.22%
  7. Emotional Disorder: 2 people, 22.22%
  8. Chest Pain: 2 people, 22.22%
  9. Irritable Bowel Syndrome: 2 people, 22.22%
  10. Cardiac Failure Congestive: 2 people, 22.22%

Common conditions people have *:

  1. Insomnia (sleeplessness): 1 person, 11.11%
  2. Duodenogastric Reflux (bile flows upward from the small intestine into the stomach): 1 person, 11.11%
  3. Depression: 1 person, 11.11%
  4. Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 1 person, 11.11%

* Approximation only. Some reports may have incomplete information.

Do you take Protonix and have Tic?

Check whether Tic is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Tic and when was it recovered:

Expand to all the drugs that have ingredients of pantoprazole sodium:

Alternative drugs to, pros and cons of Protonix:

Common Protonix side effects:

Browse all side effects of Protonix:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Tic treatments and more:

  • Tic (6,091 reports)

COVID vaccines that are related to Tic:

Common drugs associated with Tic:

All the drugs that are associated with Tic:

  • Tic (997 drugs)

Common conditions associated with Tic:

All the conditions that are associated with Tic:

  • Tic (620 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on pantoprazole sodium (the active ingredients of Protonix) and Protonix (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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