Provera and Sjogren syndrome - a phase IV clinical study of FDA data

Summary:

Sjogren syndrome is found among people who take Provera, especially for people who are female, 50-59 old, have been taking the drug for 5 - 10 years.

The phase IV clinical study analyzes which people take Provera and have Sjogren syndrome. It is created by eHealthMe based on reports of 50,942 people who have side effects when taking Provera from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse drug outcomes and monitor effectiveness. Our original studies have been referenced on 600+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Most recently, phase IV clinial trails for COVID 19 vaccines have been added, check here.

On May, 22, 2022

50,942 people reported to have side effects when taking Provera.
Among them, 49 people (0.1%) have Sjogren syndrome.

What is Provera?

Provera has active ingredients of medroxyprogesterone acetate. It is often used in birth control. eHealthMe is studying from 52,402 Provera users for its effectiveness, alternative drugs and more.

What is Sjogren syndrome?

Sjogren syndrome (a disease that causes dryness in the mouth and eyes) is found to be associated with 1,231 drugs and 792 conditions by eHealthMe.

Number of Provera and Sjogren syndrome reports submitted per year:

Time on Provera when people have Sjogren syndrome *:

Gender of people who have Sjogren syndrome when taking Provera *:

female: 100 %
male: 0.0 %

Age of people who have Sjogren syndrome when taking Provera *:

Common drugs people take besides Provera *:

Common side effects people have besides Sjogren syndrome *:

High Blood Cholesterol: 43 people, 87.76%
Anaemia (lack of blood): 34 people, 69.39%
Visual Acuity Reduced (reduced clearness of vision): 32 people, 65.31%
Diarrhea: 31 people, 63.27%
Cartilage Injury: 31 people, 63.27%
Renal Tubular Acidosis (medical condition that involves an accumulation of acid in the body due to a failure of the kidneys): 31 people, 63.27%
Joint Injury: 31 people, 63.27%
Nausea (feeling of having an urge to vomit): 31 people, 63.27%
Tooth Abscess (pus formation in tooth): 31 people, 63.27%
Osteomyelitis Chronic (long lasting infection of bone marrow): 31 people, 63.27%

Common conditions people have *:

Osteopenia (a condition where bone mineral density is lower than normal): 16 people, 32.65%
Osteoporosis (bones weak and more likely to break): 5 people, 10.20%
High Blood Cholesterol: 4 people, 8.16%
Menopause (end of monthly cycles in women): 2 people, 4.08%
Thyroid Diseases: 1 person, 2.04%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 2.04%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 2.04%
Migraine (headache): 1 person, 2.04%

* Approximation only. Some reports may have incomplete information.

Do you take Provera and have Sjogren syndrome?

Check whether Sjogren syndrome is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Bahall M, Reyes AJ, Ramcharan K, Hosein N, Seegobin K, Bahall K, Sharma H, Dhansingh S, Mahabir A, "Neuro-ophthalmological manifestations after intramuscular medroxyprogesterone: a forme fruste of idiopathic intracranial hypertension?", Neurology international, 2016 Sep .

Related studies

Alternative drugs to, pros and cons of Provera:

Provera (52,402 reports)

Sjogren syndrome treatments and more:

Sjogren syndrome (9,290 reports)

COVID vaccines that are related to Sjogren syndrome:

How severe was Sjogren syndrome and when was it recovered:

Sjogren syndrome in Provera

Expand to all the drugs that have ingredients of medroxyprogesterone acetate:

Sjogren syndrome and drugs with ingredients of medroxyprogesterone acetate (50 reports)

Common drugs associated with Sjogren syndrome:

All the drugs that are associated with Sjogren syndrome:

Sjogren syndrome (1,231 drugs)

Common conditions associated with Sjogren syndrome:

Arthritis - rheumatoid: 1,043 reports
Blood pressure increased: 156 reports
Depression: 118 reports
High blood pressure: 156 reports
Htn: 156 reports
Hypertension: 162 reports
Ms: 172 reports
Ms hug: 172 reports
Multiple sclerosis: 172 reports
Multiple sclerosis aggravated: 172 reports
Narcolepsy: 145 reports
Osteopenia: 113 reports
Osteoporosis: 335 reports
Pain: 189 reports
Pain management: 186 reports
Psoriasis: 105 reports
Ra: 1,120 reports
Rheumatoid arthritis: 1,120 reports

All the conditions that are associated with Sjogren syndrome:

Sjogren syndrome (792 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on medroxyprogesterone acetate (the active ingredients of Provera) and Provera (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.