Pyrazinamide and Ards (acute respiratory distress syndrome) - a phase IV clinical study of FDA data

Summary:

Ards (acute respiratory distress syndrome) is found among people who take Pyrazinamide, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months.

The phase IV clinical study analyzes which people take Pyrazinamide and have Ards (acute respiratory distress syndrome). It is created by eHealthMe based on reports of 8,874 people who have side effects when taking Pyrazinamide from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.



On Sep, 27, 2022

8,874 people reported to have side effects when taking Pyrazinamide.
Among them, 48 people (0.54%) have Ards (acute respiratory distress syndrome).


What is Pyrazinamide?

Pyrazinamide has active ingredients of pyrazinamide. It is often used in tuberculosis. eHealthMe is studying from 8,916 Pyrazinamide users for its effectiveness, alternative drugs and more.

What is Ards (acute respiratory distress syndrome)?

Ards (acute respiratory distress syndrome) (sudden failure of the respiratory (breathing) system) is found to be associated with 2,407 drugs and 2,206 conditions by eHealthMe.

Number of Pyrazinamide and Ards (acute respiratory distress syndrome) reports submitted per year:

Could Pyrazinamide cause Ards (acute respiratory distress syndrome)?

Time on Pyrazinamide when people have Ards (acute respiratory distress syndrome) *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 100 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Ards (acute respiratory distress syndrome) when taking Pyrazinamide *:

  • female: 58.7 %
  • male: 41.3 %

Age of people who have Ards (acute respiratory distress syndrome) when taking Pyrazinamide *:

  • 0-1: 2.33 %
  • 2-9: 0.0 %
  • 10-19: 18.6 %
  • 20-29: 11.63 %
  • 30-39: 6.98 %
  • 40-49: 13.95 %
  • 50-59: 23.26 %
  • 60+: 23.26 %

Common drugs people take besides Pyrazinamide *:

  1. Isoniazid: 23 people, 47.92%
  2. Rifampin: 8 people, 16.67%
  3. Ethambutol Hydrochloride: 6 people, 12.50%
  4. Ciclosporin: 6 people, 12.50%
  5. Vancomycin: 4 people, 8.33%
  6. Pyridoxine: 4 people, 8.33%
  7. Heparin: 3 people, 6.25%
  8. Pantoprazole: 3 people, 6.25%
  9. Humulin R: 3 people, 6.25%
  10. Piperacillin And Tazobactam: 3 people, 6.25%

Common side effects people have besides Ards (acute respiratory distress syndrome) *:

  1. Fever: 14 people, 29.17%
  2. Pneumonia: 13 people, 27.08%
  3. Breathing Difficulty: 11 people, 22.92%
  4. Septic Shock (shock due to blood infection): 10 people, 20.83%
  5. Pseudomonas Infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa): 10 people, 20.83%
  6. Drug Level Decreased: 8 people, 16.67%
  7. Sepsis (a severe blood infection that can lead to organ failure and death): 8 people, 16.67%
  8. Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 8 people, 16.67%
  9. Hypotension (abnormally low blood pressure): 8 people, 16.67%
  10. Staphylococcal Infection (an infection with staphylococcus bacteria): 7 people, 14.58%

Common conditions people have *:

  1. Disseminated Tuberculosis: 11 people, 22.92%
  2. Lymph Node Tuberculosis: 8 people, 16.67%
  3. Tuberculosis Gastrointestinal (a bacterial infection of digestive tract by mycobacterium tuberculosis): 5 people, 10.42%
  4. Pulmonary Tuberculosis (lungs tuberculosis): 5 people, 10.42%
  5. Hypotension (abnormally low blood pressure): 4 people, 8.33%
  6. Psoriasis (immune-mediated disease that affects the skin): 3 people, 6.25%
  7. Immunodeficiency Disorders: 3 people, 6.25%
  8. Evans Syndrome (autoimmune disorder in which the body makes antibodies that destroy the red blood cells, platelets): 2 people, 4.17%
  9. Pseudomonas Infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa): 1 person, 2.08%
  10. Henoch-Schonlein Purpura (inflammation of the blood vessels in the skin and other body organs): 1 person, 2.08%

* Approximation only. Some reports may have incomplete information.

Do you take Pyrazinamide and have Ards (acute respiratory distress syndrome)?

Check whether Ards (acute respiratory distress syndrome) is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.



Related studies

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Common Pyrazinamide side effects:

Browse all side effects of Pyrazinamide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Ards (acute respiratory distress syndrome) treatments and more:

COVID vaccines that are related to Ards (acute respiratory distress syndrome):

Common drugs associated with Ards (acute respiratory distress syndrome):

All the drugs that are associated with Ards (acute respiratory distress syndrome):

Common conditions associated with Ards (acute respiratory distress syndrome):

All the conditions that are associated with Ards (acute respiratory distress syndrome):

How the study uses the data?

The study uses data from the FDA. It is based on pyrazinamide (the active ingredients of Pyrazinamide) and Pyrazinamide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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