Restasis and Hearing loss - a phase IV clinical study of FDA data


Hearing loss is found among people who take Restasis, especially for people who are female, 50-59 old, have been taking the drug for < 1 month.

The phase IV clinical study analyzes which people take Restasis and have Hearing loss. It is created by eHealthMe based on reports of 28,351 people who have side effects when taking Restasis from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse drug outcomes and monitor effectiveness. Our original studies have been referenced on 600+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Most recently, phase IV clinial trails for COVID 19 vaccines have been added, check here.

On Jun, 29, 2022

28,351 people reported to have side effects when taking Restasis.
Among them, 52 people (0.18%) have Hearing loss.

What is Restasis?

Restasis has active ingredients of cyclosporine. It is often used in dry eyes. eHealthMe is studying from 28,800 Restasis users for its effectiveness, alternative drugs and more.

What is Hearing loss?

Hearing loss is found to be associated with 2,566 drugs and 2,146 conditions by eHealthMe.

Number of Restasis and Hearing loss reports submitted per year:

Could Restasis cause Hearing loss?

Time on Restasis when people have Hearing loss *:

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Hearing loss when taking Restasis *:

  • female: 88.46 %
  • male: 11.54 %

Age of people who have Hearing loss when taking Restasis *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 4.88 %
  • 50-59: 48.78 %
  • 60+: 46.34 %

Common drugs people take besides Restasis *:

  1. Coumadin: 24 people, 46.15%
  2. Lasix: 18 people, 34.62%
  3. Simvastatin: 18 people, 34.62%
  4. Valium: 18 people, 34.62%
  5. Hydrocortisone: 17 people, 32.69%
  6. Plavix: 17 people, 32.69%
  7. Paxil: 17 people, 32.69%
  8. Oxycontin: 17 people, 32.69%
  9. Ms Contin: 17 people, 32.69%
  10. Kytril: 17 people, 32.69%

Common side effects people have besides Hearing loss *:

  1. Weight Decreased: 24 people, 46.15%
  2. Pain: 21 people, 40.38%
  3. Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 21 people, 40.38%
  4. Swallowing Difficulty: 20 people, 38.46%
  5. Cardiac Disorder: 19 people, 36.54%
  6. Hypotension (abnormally low blood pressure): 18 people, 34.62%
  7. Coronary Heart Disease (narrowing or blockage of the coronary arteries): 17 people, 32.69%
  8. Cellulitis (infection under the skin): 17 people, 32.69%
  9. Malnutrition (condition that results from eating a diet in which certain nutrients are lacking): 17 people, 32.69%
  10. Cardiac Failure Congestive: 17 people, 32.69%

Common conditions people have *:

  1. Multiple Myeloma (cancer of the plasma cells): 17 people, 32.69%
  2. Hypercalcaemia Of Malignancy (elevated calcium (ca+) level in the blood with cancer): 17 people, 32.69%
  3. Hypercalcaemia (elevated calcium (ca+) level in the blood): 12 people, 23.08%
  4. Asthma: 9 people, 17.31%
  5. High Blood Cholesterol: 8 people, 15.38%
  6. Back Pain: 7 people, 13.46%
  7. Fibromyalgia (a long-term condition which causes pain all over the body): 7 people, 13.46%
  8. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 13.46%
  9. High Blood Pressure: 7 people, 13.46%
  10. Indigestion: 6 people, 11.54%

* Approximation only. Some reports may have incomplete information.

Do you take Restasis and have Hearing loss?

Check whether Hearing loss is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

Alternative drugs to, pros and cons of Restasis:

Hearing loss treatments and more:

COVID vaccines that are related to Hearing loss:

How severe was Hearing loss and when was it recovered:

Expand to all the drugs that have ingredients of cyclosporine:

Common drugs associated with Hearing loss:

All the drugs that are associated with Hearing loss:

Common conditions associated with Hearing loss:

All the conditions that are associated with Hearing loss:

How the study uses the data?

The study uses data from the FDA. It is based on cyclosporine (the active ingredients of Restasis) and Restasis (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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