Risperidone and Compartment syndrome - a phase IV clinical study of FDA data

Summary:

We study 66,756 people who have side effects when taking Risperidone. Compartment syndrome is found, especially among people who are female, 60+ old, have been taking the drug for 1 - 6 months, also take Amphetamine and have Insomnia.

The phase IV clinical study analyzes which people take Risperidone and have Compartment syndrome. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

On Sep, 25, 2023

66,756 people reported to have side effects when taking Risperidone.
Among them, 43 people (0.06%) have Compartment syndrome.

What is Risperidone?

Risperidone has active ingredients of risperidone. It is used in bipolar disorder. Currently, eHealthMe is studying from 68,118 Risperidone users.

What is Compartment syndrome?

Compartment syndrome (painful condition that occurs when pressure within the muscles builds to dangerous levels) is found to be associated with 881 drugs and 413 conditions by eHealthMe. Currently, we are studying 3,078 people who have Compartment syndrome.

Number of Risperidone and Compartment syndrome reports submitted per year:

Could Risperidone cause Compartment syndrome?

Time on Risperidone when people have Compartment syndrome *:

Gender of people who have Compartment syndrome when taking Risperidone *:

female: 72.5 %
male: 27.5 %

Age of people who have Compartment syndrome when taking Risperidone *:

Common drugs people take besides Risperidone *:

Common side effects people have besides Compartment syndrome *:

Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down): 40 people, 93.02%
Serotonin Syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time): 30 people, 69.77%
Encephalopathy (functioning of the brain is affected by some agent or condition): 20 people, 46.51%
Neuroleptic Malignant Syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents): 7 people, 16.28%
Wound Infection: 3 people, 6.98%
Blood Creatine Phosphokinase Increased: 3 people, 6.98%
Clonus (series of involuntary, rhythmic, muscular contractions and relaxations): 2 people, 4.65%
Fatigue (feeling of tiredness): 2 people, 4.65%
Muscle Necrosis (muscle cell damage): 2 people, 4.65%
Muscle Rigidity (muscle stiffness): 2 people, 4.65%

Common conditions people have *:

Insomnia (sleeplessness): 25 people, 58.14%
Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 2 people, 4.65%
Type 2 Diabetes: 1 person, 2.33%
Stress And Anxiety: 1 person, 2.33%
Schizophrenia, Paranoid Type (delusions and auditory hallucinations but relatively normal intellectual functioning and expression of affect): 1 person, 2.33%
Psychotic Disorder: 1 person, 2.33%
Oxygen Saturation Abnormal: 1 person, 2.33%
Hyperlipidaemia (presence of excess lipids in the blood): 1 person, 2.33%

* Approximation only. Some reports may have incomplete information.

Do you take Risperidone and have Compartment syndrome?

Check whether Compartment syndrome is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Janardhana P, Nagaraj AK, Basavanna PL, "Risperidone-induced skin rash", Indian journal of psychiatry, 2016 Jan .
Dsouza MC, "Could risperidone have caused the cataract?: A case report and review of literature", Journal of Research in Psychiatry and Behavioral Science, 2015 Jan .
Dsouza MC, "COULD RISPERIDONE HAVE CAUSED THE CATARACT", JRPBS, 2015 Jan .
Ray RK, Bashir MA, Rao S, "Co-Administration of Risperidone and Sodium Valproate Causing Bilateral Chronic Exertional Lower Leg Compartment Syndrome", Open Journal of Orthopedics, 2014 Apr .
Hosseini, S. H., & Ahmadi, A., "Peripheral edema occurring during treatment with risperidone combined with citalopram", Case reports in medicine, 2012 Jan .

Related studies

How severe was Compartment syndrome and when was it recovered:

Compartment syndrome in Risperidone

Expand to all the drugs that have ingredients of risperidone:

Compartment syndrome and drugs with ingredients of risperidone (68 reports)

Alternative drugs to, pros and cons of Risperidone:

Risperidone (68,118 reports)

Browse all side effects of Risperidone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Compartment syndrome treatments and more:

Compartment syndrome (3,078 reports)

Common drugs associated with Compartment syndrome:

Heparin: 216 reports
Aspirin: 173 reports
Xarelto: 129 reports
Simvastatin: 120 reports

How the study uses the data?

The study uses data from the FDA. It is based on risperidone (the active ingredients of Risperidone) and Risperidone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.