Risperidone and Hepatic necrosis - a phase IV clinical study of FDA data


Hepatic necrosis is found among people who take Risperidone, especially for people who are female, 10-19 old, have been taking the drug for 1 - 2 years.

The phase IV clinical study analyzes which people take Risperidone and have Hepatic necrosis. It is created by eHealthMe based on reports of 61,258 people who have side effects when taking Risperidone from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Feb, 07, 2023

61,258 people reported to have side effects when taking Risperidone.
Among them, 20 people (0.03%) have Hepatic necrosis.

What is Risperidone?

Risperidone has active ingredients of risperidone. It is often used in bipolar disorder. eHealthMe is studying from 62,590 Risperidone users for its effectiveness, alternative drugs and more.

What is Hepatic necrosis?

Hepatic necrosis (large portions of liver die off due to severe liver disease) is found to be associated with 1,275 drugs and 721 conditions by eHealthMe.

Number of Risperidone and Hepatic necrosis reports submitted per year:

Could Risperidone cause Hepatic necrosis?

Time on Risperidone when people have Hepatic necrosis *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 100 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Hepatic necrosis when taking Risperidone *:

  • female: 85 %
  • male: 15 %

Age of people who have Hepatic necrosis when taking Risperidone *:

  • 0-1: 0.0 %
  • 2-9: 10.53 %
  • 10-19: 36.84 %
  • 20-29: 5.26 %
  • 30-39: 10.53 %
  • 40-49: 10.53 %
  • 50-59: 5.26 %
  • 60+: 21.05 %

Common drugs people take besides Risperidone *:

  1. Paliperidone Palmitate: 4 people, 20.00%
  2. Clozapine: 3 people, 15.00%
  3. Olanzapine: 3 people, 15.00%
  4. Acetaminophen: 3 people, 15.00%
  5. Citalopram Hydrobromide: 2 people, 10.00%
  6. Slow-K: 2 people, 10.00%
  7. Rozerem: 2 people, 10.00%
  8. Paracetamol: 2 people, 10.00%
  9. Epinastine Hydrochloride: 2 people, 10.00%
  10. Loxapine: 2 people, 10.00%

Common side effects people have besides Hepatic necrosis *:

  1. Multi-Organ Failure (multisystem organ failure): 7 people, 35.00%
  2. Cholestasis (a condition where bile cannot flow from the liver to the duodenum): 6 people, 30.00%
  3. Necrotising Colitis (inflammation in the intestines (usually the colon) that can be life-threatening): 6 people, 30.00%
  4. Hepatic Encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure): 4 people, 20.00%
  5. Hepatic Failure (liver failure): 4 people, 20.00%
  6. Thrombocytopenia (decrease of platelets in blood): 4 people, 20.00%
  7. Liver Disorder (liver diseases): 3 people, 15.00%
  8. Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down): 3 people, 15.00%
  9. Neutrophil Count Decreased (less than normal number of neutrophil a type of blood cell): 3 people, 15.00%
  10. Abdominal Pain Upper: 3 people, 15.00%

Common conditions people have *:

  1. Schizophrenia, Paranoid Type (delusions and auditory hallucinations but relatively normal intellectual functioning and expression of affect): 2 people, 10.00%
  2. Insomnia (sleeplessness): 2 people, 10.00%
  3. Suicide Attempt: 1 person, 5.00%
  4. Indigestion: 1 person, 5.00%
  5. Dyskinesia (abnormality or impairment of voluntary movement): 1 person, 5.00%
  6. Constipation: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Risperidone and have Hepatic necrosis?

Check whether Hepatic necrosis is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

How severe was Hepatic necrosis and when was it recovered:

Expand to all the drugs that have ingredients of risperidone:

Alternative drugs to, pros and cons of Risperidone:

Common Risperidone side effects:

Browse all side effects of Risperidone:

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Hepatic necrosis treatments and more:

COVID vaccines that are related to Hepatic necrosis:

Common drugs associated with Hepatic necrosis:

All the drugs that are associated with Hepatic necrosis:

Common conditions associated with Hepatic necrosis:

All the conditions that are associated with Hepatic necrosis:

How the study uses the data?

The study uses data from the FDA. It is based on risperidone (the active ingredients of Risperidone) and Risperidone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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