Sam-e and Carpal tunnel syndrome - a phase IV clinical study of FDA data


Carpal tunnel syndrome is reported only by a few people who take Sam-E.

The phase IV clinical study analyzes which people take Sam-e and have Carpal tunnel syndrome. It is created by eHealthMe based on reports of 156 people who have side effects while taking Sam-e from the FDA, and is updated regularly.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Dec, 03, 2022

156 people reported to have side effects when taking Sam-e.
Among them, 2 people (1.28%) have Carpal tunnel syndrome.

What is Sam-e?

Sam-e has active ingredients of same. It is often used in depression. eHealthMe is studying from 258 Sam-e users for its effectiveness, alternative drugs and more.

What is Carpal tunnel syndrome?

Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling) is found to be associated with 1,818 drugs and 1,153 conditions by eHealthMe.

Number of Sam-e and Carpal tunnel syndrome reports submitted per year:

Could Sam-e cause Carpal tunnel syndrome?

Gender of people who have Carpal tunnel syndrome when taking Sam-e *:

  • female: 50 %
  • male: 50 %

Age of people who have Carpal tunnel syndrome when taking Sam-e *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 0.0 %
  • 60+: 100 %

Common drugs people take besides Sam-e *:

  1. Vitamin D2: 1 person, 50.00%
  2. Tylenol: 1 person, 50.00%
  3. Turmeric: 1 person, 50.00%
  4. Plaquenil: 1 person, 50.00%
  5. Ibuprofen: 1 person, 50.00%
  6. Humira: 1 person, 50.00%

Common side effects people have besides Carpal tunnel syndrome *:

  1. Back Pain: 2 people, 100.00%
  2. Swelling: 1 person, 50.00%
  3. Spinal Cord Compression: 1 person, 50.00%
  4. Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve): 1 person, 50.00%
  5. Pain: 1 person, 50.00%
  6. Overdose: 1 person, 50.00%
  7. Neuralgia (pain in one or more nerves): 1 person, 50.00%
  8. Neck Injury: 1 person, 50.00%
  9. Local Swelling (swelling at the site of some application of substance or injury): 1 person, 50.00%
  10. Limb Injury: 1 person, 50.00%

Common conditions people have *:

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 50.00%
  2. Neck Pain: 1 person, 50.00%
  3. Constipation: 1 person, 50.00%

* Approximation only. Some reports may have incomplete information.

Do you take Sam-e and have Carpal tunnel syndrome?

Check whether Carpal tunnel syndrome is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

How severe was Carpal tunnel syndrome and when was it recovered:

Expand to all the drugs that have ingredients of same:

Alternative drugs to, pros and cons of Sam-e:

Carpal tunnel syndrome treatments and more:

COVID vaccines that are related to Carpal tunnel syndrome:

Common drugs associated with Carpal tunnel syndrome:

All the drugs that are associated with Carpal tunnel syndrome:

Common conditions associated with Carpal tunnel syndrome:

All the conditions that are associated with Carpal tunnel syndrome:

How the study uses the data?

The study uses data from the FDA. It is based on same (the active ingredients of Sam-e) and Sam-e (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe: