Sandimmune and Hypertrophic cardiomyopathy - a phase IV clinical study of FDA data

Summary:

Hypertrophic cardiomyopathy is found among people who take Sandimmune, especially for people who are male, 2-9 old, have been taking the drug for < 1 month.

The phase IV clinical study analyzes which people take Sandimmune and have Hypertrophic cardiomyopathy. It is created by eHealthMe based on reports of 6,610 people who have side effects when taking Sandimmune from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Feb, 03, 2023

6,610 people reported to have side effects when taking Sandimmune.
Among them, 9 people (0.14%) have Hypertrophic cardiomyopathy.

What is Sandimmune?

Sandimmune has active ingredients of cyclosporine. eHealthMe is studying from 6,623 Sandimmune users for its effectiveness, alternative drugs and more.

What is Hypertrophic cardiomyopathy?

Hypertrophic cardiomyopathy (a condition in which the heart muscle becomes abnormally thick) is found to be associated with 997 drugs and 833 conditions by eHealthMe.

Number of Sandimmune and Hypertrophic cardiomyopathy reports submitted per year:

Could Sandimmune cause Hypertrophic cardiomyopathy?

Time on Sandimmune when people have Hypertrophic cardiomyopathy *:

Gender of people who have Hypertrophic cardiomyopathy when taking Sandimmune *:

female: 25 %
male: 75 %

Age of people who have Hypertrophic cardiomyopathy when taking Sandimmune *:

Common drugs people take besides Sandimmune *:

Prednisolone: 7 people, 77.78%
Fludara: 4 people, 44.44%
Methotrexate: 4 people, 44.44%
Diflucan: 3 people, 33.33%
Dopamine Hydrochloride: 3 people, 33.33%
Alendronate Sodium: 3 people, 33.33%
Rapamune: 2 people, 22.22%
Cellcept: 2 people, 22.22%
Lasix: 2 people, 22.22%
Isoptin: 2 people, 22.22%

Common side effects people have besides Hypertrophic cardiomyopathy *:

Pancreatitis Acute (sudden inflammation of pancreas): 3 people, 33.33%
Urine Output - Decreased: 2 people, 22.22%
Multi-Organ Failure (multisystem organ failure): 2 people, 22.22%
Cardiac Failure Aggravated: 2 people, 22.22%
Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 2 people, 22.22%
Muscle Rigidity (muscle stiffness): 2 people, 22.22%
Pneumonia Pseudomonal (pseudomonas pneumonia is an infection caused by the microbe known as pseudomonas aeruginosa): 2 people, 22.22%
Mitral Valve Incompetence (inefficient heart valve): 1 person, 11.11%
Left Ventricular Hypertrophy (the thickening of the myocardium (muscle) of the left ventricle of the heart): 1 person, 11.11%
Interstitial Lung Disease: 1 person, 11.11%

Common conditions people have *:

Hyperuricaemia (level of uric acid in the blood that is abnormally high): 1 person, 11.11%
Fabry's Disease (build up of a particular type of fat, called globotriaosylceramide, in the body's cells): 1 person, 11.11%

* Approximation only. Some reports may have incomplete information.

Do you take Sandimmune and have Hypertrophic cardiomyopathy?

Check whether Hypertrophic cardiomyopathy is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

O’Brien FE, O’Connor RM, Clarke G, Donovan MD, Dinan TG, Griffin BT, Cryan JF, "The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram", Behavioural brain research, 2014 Mar .
Kim DJ, Lee SC, Park GS, Kim GJ, Hwang WT, Lee CS, Lee MH, Hahn DH, Koh HC, "Amiodarone Induced Multiorgan Toxicity in a Patient of Hypertrophic Cardiomyopathy With Atrial Fibrillation", Journal of the Korean Geriatrics Society, 2013 Dec .

Related studies

How severe was Hypertrophic cardiomyopathy and when was it recovered:

Hypertrophic cardiomyopathy in Sandimmune

Expand to all the drugs that have ingredients of cyclosporine:

Hypertrophic cardiomyopathy and drugs with ingredients of cyclosporine (41 reports)

Alternative drugs to, pros and cons of Sandimmune:

Sandimmune (6,623 reports)

Common Sandimmune side effects:

Browse all side effects of Sandimmune:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Hypertrophic cardiomyopathy treatments and more:

Hypertrophic cardiomyopathy (2,577 reports)

COVID vaccines that are related to Hypertrophic cardiomyopathy:

Common drugs associated with Hypertrophic cardiomyopathy:

Prednisone: 115 reports
Lasix: 106 reports
Furosemide: 103 reports

How the study uses the data?

The study uses data from the FDA. It is based on cyclosporine (the active ingredients of Sandimmune) and Sandimmune (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.