Senna and Respiratory depression - a phase IV clinical study of FDA data


Respiratory depression is found among people who take Senna, especially for people who are female, 60+ old, have been taking the drug for < 1 month.

The phase IV clinical study analyzes which people take Senna and have Respiratory depression. It is created by eHealthMe based on reports of 31,680 people who have side effects when taking Senna from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Aug, 12, 2022

31,680 people reported to have side effects when taking Senna.
Among them, 22 people (0.07%) have Respiratory depression.

What is Senna?

Senna has active ingredients of senna. It is often used in constipation. eHealthMe is studying from 28,791 Senna users for its effectiveness, alternative drugs and more.

What is Respiratory depression?

Respiratory depression (respiration has a rate below 12 breaths) is found to be associated with 1,278 drugs and 795 conditions by eHealthMe.

Number of Senna and Respiratory depression reports submitted per year:

Could Senna cause Respiratory depression?

Time on Senna when people have Respiratory depression *:

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Respiratory depression when taking Senna *:

  • female: 54.55 %
  • male: 45.45 %

Age of people who have Respiratory depression when taking Senna *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 10 %
  • 20-29: 0.0 %
  • 30-39: 15 %
  • 40-49: 10 %
  • 50-59: 10 %
  • 60+: 55 %

Common drugs people take besides Senna *:

  1. Paracetamol: 6 people, 27.27%
  2. Alendronic Acid: 6 people, 27.27%
  3. Ipratropium Bromide: 5 people, 22.73%
  4. Pregabalin: 5 people, 22.73%
  5. Furosemide: 5 people, 22.73%
  6. Gabapentin: 4 people, 18.18%
  7. Levothyroxine Sodium: 4 people, 18.18%
  8. Phenelzine Sulfate: 4 people, 18.18%
  9. Colace: 4 people, 18.18%
  10. Priadel: 4 people, 18.18%

Common side effects people have besides Respiratory depression *:

  1. Depressed Level Of Consciousness: 6 people, 27.27%
  2. Drowsiness: 3 people, 13.64%
  3. Breathing Difficulty: 2 people, 9.09%
  4. Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 2 people, 9.09%
  5. Meningitis Aseptic (a condition that causes the membranes covering your brain and spinal cord to become inflamed): 2 people, 9.09%
  6. Mental Status Changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 2 people, 9.09%
  7. Unresponsive To Stimuli: 1 person, 4.55%
  8. Dehydration (dryness resulting from the removal of water): 1 person, 4.55%
  9. Fatigue (feeling of tiredness): 1 person, 4.55%
  10. Eye Movements - Uncontrollable: 1 person, 4.55%

Common conditions people have *:

  1. Pain: 7 people, 31.82%
  2. Chronic Inflammatory Demyelinating Polyradiculoneuropathy (long lasting infection of nerves outside brain and spinal cord): 3 people, 13.64%
  3. Itching: 2 people, 9.09%
  4. Insomnia (sleeplessness): 2 people, 9.09%
  5. Wheezing (a high-pitched whistling sound made while you breath): 1 person, 4.55%
  6. Pharyngitis (inflammation of the pharynx, causing a sore throat): 1 person, 4.55%
  7. Neuroendocrine Tumor: 1 person, 4.55%
  8. Dementia Alzheimer's Type (loss of mental ability with alzheimer's symptom): 1 person, 4.55%
  9. Cough: 1 person, 4.55%
  10. Cancer Pain: 1 person, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Senna and have Respiratory depression?

Check whether Respiratory depression is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

How severe was Respiratory depression and when was it recovered:

Expand to all the drugs that have ingredients of senna:

Alternative drugs to, pros and cons of Senna:

Common Senna side effects:

Browse all side effects of Senna:

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Respiratory depression treatments and more:

COVID vaccines that are related to Respiratory depression:

Common drugs associated with Respiratory depression:

All the drugs that are associated with Respiratory depression:

Common conditions associated with Respiratory depression:

All the conditions that are associated with Respiratory depression:

How the study uses the data?

The study uses data from the FDA. It is based on senna (the active ingredients of Senna) and Senna (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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