Seroquel xr and Rectal haemorrhage - a phase IV clinical study of FDA data


Rectal haemorrhage is found among people who take Seroquel xr, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months.

The phase IV clinical study analyzes which people take Seroquel xr and have Rectal haemorrhage. It is created by eHealthMe based on reports of 10,252 people who have side effects when taking Seroquel xr from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse drug outcomes and monitor effectiveness. Our original studies have been referenced on 600+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Most recently, phase IV clinial trails for COVID 19 vaccines have been added, check here.

On May, 18, 2022

10,252 people reported to have side effects when taking Seroquel xr.
Among them, 16 people (0.16%) have Rectal haemorrhage.

What is Seroquel xr?

Seroquel xr has active ingredients of quetiapine fumarate. It is often used in bipolar disorder. eHealthMe is studying from 11,481 Seroquel xr users for its effectiveness, alternative drugs and more.

What is Rectal haemorrhage?

Rectal haemorrhage (bleeding from anus) is found to be associated with 2,106 drugs and 1,486 conditions by eHealthMe.

Number of Seroquel xr and Rectal haemorrhage reports submitted per year:

Could Seroquel xr cause Rectal haemorrhage?

Time on Seroquel xr when people have Rectal haemorrhage *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 100 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Rectal haemorrhage when taking Seroquel xr *:

  • female: 60 %
  • male: 40 %

Age of people who have Rectal haemorrhage when taking Seroquel xr *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 7.14 %
  • 30-39: 7.14 %
  • 40-49: 0.0 %
  • 50-59: 42.86 %
  • 60+: 42.86 %

Common drugs people take besides Seroquel xr *:

  1. Zyprexa: 2 people, 12.50%
  2. Toprol-Xl: 2 people, 12.50%
  3. Klonopin: 2 people, 12.50%
  4. Ibuprofen: 2 people, 12.50%
  5. Nexium: 2 people, 12.50%
  6. Norvasc: 2 people, 12.50%
  7. Percocet: 2 people, 12.50%
  8. Synthroid: 2 people, 12.50%
  9. Prozac: 2 people, 12.50%
  10. Accutane: 2 people, 12.50%

Common side effects people have besides Rectal haemorrhage *:

  1. Diarrhea: 5 people, 31.25%
  2. Fatigue (feeling of tiredness): 4 people, 25.00%
  3. Abdominal Pain: 3 people, 18.75%
  4. Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 3 people, 18.75%
  5. Malaise (a feeling of general discomfort or uneasiness): 3 people, 18.75%
  6. Insomnia (sleeplessness): 3 people, 18.75%
  7. Drug Ineffective: 3 people, 18.75%
  8. Nausea (feeling of having an urge to vomit): 3 people, 18.75%
  9. Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 3 people, 18.75%
  10. Weakness: 3 people, 18.75%

Common conditions people have *:

  1. Depression: 3 people, 18.75%
  2. High Blood Pressure: 2 people, 12.50%
  3. Sleep Disorder: 2 people, 12.50%
  4. Enlarged Prostate: 1 person, 6.25%
  5. Agitation (state of anxiety or nervous excitement): 1 person, 6.25%
  6. Arrhythmias (irregular heartbeat): 1 person, 6.25%
  7. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 6.25%
  8. Colon Cancer: 1 person, 6.25%
  9. Embolism (obstruction of an artery, typically by a clot of blood or an air bubble): 1 person, 6.25%
  10. Thyroid Diseases: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Seroquel xr and have Rectal haemorrhage?

Check whether Rectal haemorrhage is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

Alternative drugs to, pros and cons of Seroquel xr:

Rectal haemorrhage treatments and more:

COVID vaccines that are related to Rectal haemorrhage:

How severe was Rectal haemorrhage and when was it recovered:

Expand to all the drugs that have ingredients of quetiapine fumarate:

Common drugs associated with Rectal haemorrhage:

All the drugs that are associated with Rectal haemorrhage:

Common conditions associated with Rectal haemorrhage:

All the conditions that are associated with Rectal haemorrhage:

How the study uses the data?

The study uses data from the FDA. It is based on quetiapine fumarate (the active ingredients of Seroquel xr) and Seroquel xr (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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