Seroquel and Application site pruritus - a phase IV clinical study of FDA data


Application site pruritus is found among people who take Seroquel, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months.

The phase IV clinical study analyzes which people take Seroquel and have Application site pruritus. It is created by eHealthMe based on reports of 108,921 people who have side effects when taking Seroquel from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Jan, 30, 2023

108,921 people reported to have side effects when taking Seroquel.
Among them, 55 people (0.05%) have Application site pruritus.

What is Seroquel?

Seroquel has active ingredients of quetiapine fumarate. It is often used in bipolar disorder. eHealthMe is studying from 115,349 Seroquel users for its effectiveness, alternative drugs and more.

What is Application site pruritus?

Application site pruritus (application site severe itching of the skin) is found to be associated with 1,163 drugs and 846 conditions by eHealthMe.

Number of Seroquel and Application site pruritus reports submitted per year:

Could Seroquel cause Application site pruritus?

Time on Seroquel when people have Application site pruritus *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 50 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 50 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Application site pruritus when taking Seroquel *:

  • female: 73.58 %
  • male: 26.42 %

Age of people who have Application site pruritus when taking Seroquel *:

  • 0-1: 0.0 %
  • 2-9: 2.17 %
  • 10-19: 6.52 %
  • 20-29: 6.52 %
  • 30-39: 4.35 %
  • 40-49: 26.09 %
  • 50-59: 21.74 %
  • 60+: 32.61 %

Common drugs people take besides Seroquel *:

  1. Lantus: 6 people, 10.91%
  2. Benadryl: 6 people, 10.91%
  3. Daytrana: 5 people, 9.09%
  4. Metformin: 5 people, 9.09%
  5. Valchlor: 5 people, 9.09%
  6. Nicotine: 4 people, 7.27%
  7. Pramosone: 4 people, 7.27%
  8. Vitamin D3: 4 people, 7.27%
  9. Emsam: 4 people, 7.27%
  10. Wellbutrin: 4 people, 7.27%

Common side effects people have besides Application site pruritus *:

  1. Application Site Erythema (redness of the skin at application site): 29 people, 52.73%
  2. Application Site Pain: 13 people, 23.64%
  3. Application Site Irritation: 12 people, 21.82%
  4. Application Site Rash: 11 people, 20.00%
  5. Application Site Inflammation: 10 people, 18.18%
  6. Rashes (redness): 10 people, 18.18%
  7. Drug Ineffective: 7 people, 12.73%
  8. Skin Exfoliation (removal of the oldest dead skin cells): 6 people, 10.91%
  9. Application Site Urticaria: 6 people, 10.91%
  10. Skin Irritation: 5 people, 9.09%

Common conditions people have *:

  1. Quit Smoking: 8 people, 14.55%
  2. Pain: 7 people, 12.73%
  3. Sleep Disorder: 7 people, 12.73%
  4. Migraine (headache): 5 people, 9.09%
  5. Hair Loss: 4 people, 7.27%
  6. Back Pain: 4 people, 7.27%
  7. Dementia Alzheimer's Type (loss of mental ability with alzheimer's symptom): 4 people, 7.27%
  8. Mycosis Fungoides (lymphocytes (a type of white blood cell) become malignant (cancerous) and affect the skin): 4 people, 7.27%
  9. High Blood Cholesterol: 3 people, 5.45%
  10. Essential Hypertension (primary hypertension): 3 people, 5.45%

* Approximation only. Some reports may have incomplete information.

Do you take Seroquel and have Application site pruritus?

Check whether Application site pruritus is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

How severe was Application site pruritus and when was it recovered:

Expand to all the drugs that have ingredients of quetiapine fumarate:

Alternative drugs to, pros and cons of Seroquel:

Common Seroquel side effects:

Browse all side effects of Seroquel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Application site pruritus treatments and more:

COVID vaccines that are related to Application site pruritus:

Common drugs associated with Application site pruritus:

All the drugs that are associated with Application site pruritus:

Common conditions associated with Application site pruritus:

All the conditions that are associated with Application site pruritus:

How the study uses the data?

The study uses data from the FDA. It is based on quetiapine fumarate (the active ingredients of Seroquel) and Seroquel (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe: