Simponi and Glucose tolerance impaired - a phase IV clinical study of FDA data
We study 78,881 people who have side effects when taking Simponi. Glucose tolerance impaired is found, especially among people who are female, 50-59 old, have been taking the drug for 1 - 2 years, also take Humira and have Gastroesophageal reflux disease.
The phase IV clinical study analyzes which people take Simponi and have Glucose tolerance impaired. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
78,881 people reported to have side effects when taking Simponi.
Among them, 26 people (0.03%) have Glucose tolerance impaired.
What is Simponi?
Simponi has active ingredients of golimumab. It is used in rheumatoid arthritis. Currently, eHealthMe is studying from 79,099 Simponi users.
What is Glucose tolerance impaired?
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis) is found to be associated with 1,515 drugs and 822 conditions by eHealthMe. Currently, we are studying 11,930 people who have Glucose tolerance impaired.
Number of Simponi and Glucose tolerance impaired reports submitted per year:
Time on Simponi when people have Glucose tolerance impaired *:
- < 1 month: 25.0 %
- 1 - 6 months: 8.33 %
- 6 - 12 months: 8.33 %
- 1 - 2 years: 58.33 %
- 2 - 5 years: 0.0 %
- 5 - 10 years: 0.0 %
- 10+ years: 0.0 %
Gender of people who have Glucose tolerance impaired when taking Simponi *:
- female: 69.23 %
- male: 30.77 %
Age of people who have Glucose tolerance impaired when taking Simponi *:
- 0-1: 0.0 %
- 2-9: 0.0 %
- 10-19: 0.0 %
- 20-29: 0.0 %
- 30-39: 6.67 %
- 40-49: 26.67 %
- 50-59: 40.0 %
- 60+: 26.67 %
Common drugs people take besides Simponi *:
- Humira: 12 people, 46.15%
- Enbrel: 8 people, 30.77%
- Plaquenil: 7 people, 26.92%
- Cimzia: 5 people, 19.23%
- Orencia: 5 people, 19.23%
- Wellbutrin: 5 people, 19.23%
- Xeljanz: 4 people, 15.38%
- Buscopan: 4 people, 15.38%
- Methotrexate: 2 people, 7.69%
- Clopidogrel: 2 people, 7.69%
Common side effects people have besides Glucose tolerance impaired *:
- Drug Ineffective: 15 people, 57.69%
- Nausea (feeling of having an urge to vomit): 9 people, 34.62%
- High Blood Pressure: 6 people, 23.08%
- Gastric Ulcer (stomach ulcer): 6 people, 23.08%
- Joint Effusion (presence of extra fluid in joint covering): 5 people, 19.23%
- Ligament Rupture (tear in ligament): 5 people, 19.23%
- Neck Pain: 5 people, 19.23%
- High Blood Cholesterol: 5 people, 19.23%
- Osteoporosis (bones weak and more likely to break): 5 people, 19.23%
- Heart Valve Incompetence (heart's valves do not work correctly): 5 people, 19.23%
Common conditions people have *:
- Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 7.69%
- Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 7.69%
- Uveitis (inflammation of the uvea): 1 person, 3.85%
- Pain: 1 person, 3.85%
* Approximation only. Some reports may have incomplete information.
Do you take Simponi and have Glucose tolerance impaired?Check whether Glucose tolerance impaired is associated with a drug or a condition
How to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related publications that referenced our studies
- Azuma N, Matsui K, Hashimoto N, Yoshikawa T, Sano H, "Successful Switch to Golimumab for Eosinophilia and Skin Symptoms Related to Multiple Biologics in a Patient with Rheumatoid Arthritis", Internal Medicine, 2017 Jun .
Simponi side effects by duration, gender and age:
- Simponi side effects (79,099 reports)
Glucose tolerance impaired treatments and more:
- Glucose tolerance impaired (11,930 reports)
Common drugs associated with Glucose tolerance impaired:
- Lipitor: 449 reports
- Prednisone: 416 reports
- Fosamax: 389 reports
- Aspirin: 383 reports
- Seroquel: 365 reports
- Metformin: 364 reports
- Humira: 306 reports
- Zyprexa: 259 reports
- Synthroid: 254 reports
- Nexium: 222 reports
All the drugs that are associated with Glucose tolerance impaired:
- Glucose tolerance impaired (1,515 drugs)
Common conditions associated with Glucose tolerance impaired:
- High blood pressure: 507 reports
- High blood cholesterol: 465 reports
- Depression: 352 reports
- Osteoporosis: 347 reports
- Rheumatoid arthritis: 298 reports
- Pain: 220 reports
- Stress and anxiety: 219 reports
All the conditions that are associated with Glucose tolerance impaired:
- Glucose tolerance impaired (822 conditions)
How the study uses the data?
The study uses data from the FDA. It is based on golimumab (the active ingredients of Simponi) and Simponi (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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