Simponi and Hepatomegaly - a phase IV clinical study of FDA data


Hepatomegaly is found among people who take Simponi, especially for people who are female, 50-59 old, have been taking the drug for 1 - 2 years.

The phase IV clinical study analyzes which people take Simponi and have Hepatomegaly. It is created by eHealthMe based on reports of 59,265 people who have side effects when taking Simponi from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse drug outcomes and monitor effectiveness. Our original studies have been referenced on 600+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Most recently, phase IV clinial trails for COVID 19 vaccines have been added, check here.

On Jun, 30, 2022

59,265 people reported to have side effects when taking Simponi.
Among them, 23 people (0.04%) have Hepatomegaly.

What is Simponi?

Simponi has active ingredients of golimumab. It is often used in rheumatoid arthritis. eHealthMe is studying from 59,456 Simponi users for its effectiveness, alternative drugs and more.

What is Hepatomegaly?

Hepatomegaly (abnormal enlargement of the liver) is found to be associated with 2,233 drugs and 1,790 conditions by eHealthMe.

Number of Simponi and Hepatomegaly reports submitted per year:

Could Simponi cause Hepatomegaly?

Time on Simponi when people have Hepatomegaly *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 14.29 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 71.43 %
  • 2 - 5 years: 14.29 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Hepatomegaly when taking Simponi *:

  • female: 68.18 %
  • male: 31.82 %

Age of people who have Hepatomegaly when taking Simponi *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 4.55 %
  • 30-39: 31.82 %
  • 40-49: 9.09 %
  • 50-59: 40.91 %
  • 60+: 13.64 %

Common drugs people take besides Simponi *:

  1. Ventolin: 8 people, 34.78%
  2. Symbicort: 8 people, 34.78%
  3. Pantoprazole: 8 people, 34.78%
  4. Cosentyx: 8 people, 34.78%
  5. Humira: 5 people, 21.74%
  6. Rituxan: 4 people, 17.39%
  7. Methotrexate: 4 people, 17.39%
  8. Orencia: 2 people, 8.70%
  9. Zometa: 1 person, 4.35%
  10. Bumex: 1 person, 4.35%

Common side effects people have besides Hepatomegaly *:

  1. Back Pain: 10 people, 43.48%
  2. Headache (pain in head): 9 people, 39.13%
  3. Abdominal Discomfort: 8 people, 34.78%
  4. Renal Mass (mass in kidney): 8 people, 34.78%
  5. Faeces Discolored: 8 people, 34.78%
  6. Drug Hypersensitivity: 8 people, 34.78%
  7. Diarrhea: 8 people, 34.78%
  8. Infection: 8 people, 34.78%
  9. Nausea (feeling of having an urge to vomit): 8 people, 34.78%
  10. Type 2 Diabetes: 8 people, 34.78%

Common conditions people have *:

  1. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 9 people, 39.13%
  2. Psoriasis (immune-mediated disease that affects the skin): 8 people, 34.78%
  3. Oedema (fluid collection in tissue): 1 person, 4.35%
  4. Malignant Melanoma (skin cancer rises from melancytes): 1 person, 4.35%
  5. Indigestion: 1 person, 4.35%
  6. High Blood Pressure: 1 person, 4.35%
  7. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 4.35%

* Approximation only. Some reports may have incomplete information.

Do you take Simponi and have Hepatomegaly?

Check whether Hepatomegaly is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

Alternative drugs to, pros and cons of Simponi:

Hepatomegaly treatments and more:

COVID vaccines that are related to Hepatomegaly:

How severe was Hepatomegaly and when was it recovered:

Expand to all the drugs that have ingredients of golimumab:

Common drugs associated with Hepatomegaly:

All the drugs that are associated with Hepatomegaly:

Common conditions associated with Hepatomegaly:

All the conditions that are associated with Hepatomegaly:

How the study uses the data?

The study uses data from the FDA. It is based on golimumab (the active ingredients of Simponi) and Simponi (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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