Simvastatin and Urine discoloration - a phase IV clinical study of FDA data

Summary:

Urine discoloration is found among people who take Simvastatin, especially for people who are male, 60+ old.

The phase IV clinical study analyzes which people take Simvastatin and have Urine discoloration. It is created by eHealthMe based on reports of 230,650 people who have side effects when taking Simvastatin from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.



On Sep, 30, 2022

230,650 people reported to have side effects when taking Simvastatin.
Among them, 33 people (0.01%) have Urine discoloration.


What is Simvastatin?

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 238,025 Simvastatin users for its effectiveness, alternative drugs and more.

What is Urine discoloration?

Urine discoloration is found to be associated with 625 drugs and 65 conditions by eHealthMe.

Number of Simvastatin and Urine discoloration reports submitted per year:

Could Simvastatin cause Urine discoloration?

Gender of people who have Urine discoloration when taking Simvastatin *:

  • female: 28.12 %
  • male: 71.88 %

Age of people who have Urine discoloration when taking Simvastatin *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 10.71 %
  • 50-59: 25.0 %
  • 60+: 64.29 %

Common drugs people take besides Simvastatin *:

  1. Digoxin: 5 people, 15.15%
  2. Gemfibrozil: 4 people, 12.12%
  3. Levothyroxine Sodium: 4 people, 12.12%
  4. Regular Insulin: 4 people, 12.12%
  5. Allopurinol: 4 people, 12.12%
  6. Synthroid: 3 people, 9.09%
  7. Nitroglycerin: 3 people, 9.09%
  8. Prednisone: 3 people, 9.09%
  9. Azathioprine: 3 people, 9.09%
  10. Ranitidine: 3 people, 9.09%

Common side effects people have besides Urine discoloration *:

  1. Weakness: 16 people, 48.48%
  2. Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down): 13 people, 39.39%
  3. Liver Function Tests Nos Abnormal: 8 people, 24.24%
  4. Fatigue (feeling of tiredness): 8 people, 24.24%
  5. Fever: 7 people, 21.21%
  6. Blood Urea Increased: 6 people, 18.18%
  7. Hepatocellular Damage (liver damage): 6 people, 18.18%
  8. Nausea (feeling of having an urge to vomit): 6 people, 18.18%
  9. Oedema Lower Limb (fluid collection in tissue of lower leg): 6 people, 18.18%
  10. Blood Creatine Phosphokinase Increased: 6 people, 18.18%

* Approximation only. Some reports may have incomplete information.

Do you take Simvastatin and have Urine discoloration?

Check whether Urine discoloration is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.



Related studies

How severe was Urine discoloration and when was it recovered:

Expand to all the drugs that have ingredients of simvastatin:

Alternative drugs to, pros and cons of Simvastatin:

Common Simvastatin side effects:

Browse all side effects of Simvastatin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Urine discoloration treatments and more:

COVID vaccines that are related to Urine discoloration:

Common drugs associated with Urine discoloration:

All the drugs that are associated with Urine discoloration:

All the conditions that are associated with Urine discoloration:

How the study uses the data?

The study uses data from the FDA. It is based on simvastatin (the active ingredients of Simvastatin) and Simvastatin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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