Sinequan and Coughing up blood - a phase IV clinical study of FDA data


Coughing up blood is found among people who take Sinequan, especially for people who are male, 30-39 old, have been taking the drug for 1 - 2 years.

The phase IV clinical study analyzes which people take Sinequan and have Coughing up blood. It is created by eHealthMe based on reports of 1,705 people who have side effects when taking Sinequan from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Nov, 30, 2022

1,705 people reported to have side effects when taking Sinequan.
Among them, 11 people (0.65%) have Coughing up blood.

What is Sinequan?

Sinequan has active ingredients of doxepin hydrochloride. It is often used in depression. eHealthMe is studying from 1,796 Sinequan users for its effectiveness, alternative drugs and more.

What is Coughing up blood?

Coughing up blood is found to be associated with 2,556 drugs and 1,966 conditions by eHealthMe.

Number of Sinequan and Coughing up blood reports submitted per year:

Could Sinequan cause Coughing up blood?

Time on Sinequan when people have Coughing up blood *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 100 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Coughing up blood when taking Sinequan *:

  • female: 9.09 %
  • male: 90.91 %

Age of people who have Coughing up blood when taking Sinequan *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 90.91 %
  • 40-49: 0.0 %
  • 50-59: 9.09 %
  • 60+: 0.0 %

Common drugs people take besides Sinequan *:

  1. Prilosec: 10 people, 90.91%
  2. Cipro: 10 people, 90.91%
  3. Duoneb: 10 people, 90.91%
  4. Levaquin: 10 people, 90.91%
  5. Tylenol: 10 people, 90.91%
  6. Zyprexa: 9 people, 81.82%
  7. Lantus: 9 people, 81.82%
  8. Orkambi: 9 people, 81.82%
  9. Norvasc: 9 people, 81.82%
  10. Mucomyst: 9 people, 81.82%

Common side effects people have besides Coughing up blood *:

  1. Anaemia (lack of blood): 10 people, 90.91%
  2. Breathing Difficulty: 10 people, 90.91%
  3. Pneumonia: 10 people, 90.91%
  4. Weight Decreased: 9 people, 81.82%
  5. Cough: 9 people, 81.82%
  6. Haematuria (presence of blood in urine): 9 people, 81.82%
  7. Granulocytosis (the presence in peripheral blood of an increased number of granulocytes): 9 people, 81.82%
  8. Weakness: 9 people, 81.82%
  9. Generalised Oedema (swelling all over the body): 9 people, 81.82%
  10. Gastrointestinal Disorder (functional problems of gastrointestinal tract): 9 people, 81.82%

Common conditions people have *:

  1. Wheezing (a high-pitched whistling sound made while you breath): 9 people, 81.82%
  2. Sedation: 9 people, 81.82%
  3. Asthma: 9 people, 81.82%
  4. Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 9 people, 81.82%
  5. Blood Glucose Decreased: 9 people, 81.82%
  6. Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 9 people, 81.82%
  7. Cough: 9 people, 81.82%
  8. Cystic Fibrosis (disease of the secretary glands): 9 people, 81.82%
  9. Fungal Infection: 9 people, 81.82%
  10. High Blood Pressure: 9 people, 81.82%

* Approximation only. Some reports may have incomplete information.

Do you take Sinequan and have Coughing up blood?

Check whether Coughing up blood is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Coughing up blood and when was it recovered:

Expand to all the drugs that have ingredients of doxepin hydrochloride:

Alternative drugs to, pros and cons of Sinequan:

Common Sinequan side effects:

Browse all side effects of Sinequan:

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Coughing up blood treatments and more:

COVID vaccines that are related to Coughing up blood:

Common drugs associated with Coughing up blood:

All the drugs that are associated with Coughing up blood:

Common conditions associated with Coughing up blood:

All the conditions that are associated with Coughing up blood:

How the study uses the data?

The study uses data from the FDA. It is based on doxepin hydrochloride (the active ingredients of Sinequan) and Sinequan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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