Singulair and Nephrotic syndrome - a phase IV clinical study of FDA data


Nephrotic syndrome is found among people who take Singulair, especially for people who are male, 60+ old, have been taking the drug for 1 - 2 years.

The phase IV clinical study analyzes which people take Singulair and have Nephrotic syndrome. It is created by eHealthMe based on reports of 111,364 people who have side effects when taking Singulair from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Feb, 07, 2023

111,364 people reported to have side effects when taking Singulair.
Among them, 60 people (0.05%) have Nephrotic syndrome.

What is Singulair?

Singulair has active ingredients of montelukast sodium. It is often used in asthma. eHealthMe is studying from 115,413 Singulair users for its effectiveness, alternative drugs and more.

What is Nephrotic syndrome?

Nephrotic syndrome (kidney disease with proteinuria, hypoalbuminemia, and oedema) is found to be associated with 1,400 drugs and 996 conditions by eHealthMe.

Number of Singulair and Nephrotic syndrome reports submitted per year:

Could Singulair cause Nephrotic syndrome?

Time on Singulair when people have Nephrotic syndrome *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 16.67 %
  • 6 - 12 months: 16.67 %
  • 1 - 2 years: 50.0 %
  • 2 - 5 years: 16.67 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Nephrotic syndrome when taking Singulair *:

  • female: 42.86 %
  • male: 57.14 %

Age of people who have Nephrotic syndrome when taking Singulair *:

  • 0-1: 0.0 %
  • 2-9: 13.21 %
  • 10-19: 26.42 %
  • 20-29: 1.89 %
  • 30-39: 7.55 %
  • 40-49: 5.66 %
  • 50-59: 9.43 %
  • 60+: 35.85 %

Common drugs people take besides Singulair *:

  1. Zantac: 10 people, 16.67%
  2. Serevent: 8 people, 13.33%
  3. Atrovent: 8 people, 13.33%
  4. Lasix: 7 people, 11.67%
  5. Albuterol: 7 people, 11.67%
  6. Spironolactone: 7 people, 11.67%
  7. Morphine: 6 people, 10.00%
  8. Symbicort: 6 people, 10.00%
  9. Omeprazole: 6 people, 10.00%
  10. Prilosec: 6 people, 10.00%

Common side effects people have besides Nephrotic syndrome *:

  1. Interstitial Nephritis (inflammation of the kidney): 6 people, 10.00%
  2. Pneumonia: 5 people, 8.33%
  3. Allergic Granulomatous Angiitis (allergic inflammation of a blood vessel or lymph duct): 5 people, 8.33%
  4. Proteinuria Present: 5 people, 8.33%
  5. Compression Fracture (fracture due to pressure caused by injury): 5 people, 8.33%
  6. General Physical Health Deterioration (weak health status): 5 people, 8.33%
  7. Postoperative Wound Infection: 5 people, 8.33%
  8. High Blood Pressure: 5 people, 8.33%
  9. Spinal Column Stenosis (narrowing of spinal column): 4 people, 6.67%
  10. Malaise (a feeling of general discomfort or uneasiness): 4 people, 6.67%

Common conditions people have *:

  1. High Blood Pressure: 7 people, 11.67%
  2. Post Herpetic Neuralgia (neuralgia caused by the varicella zoster virus): 5 people, 8.33%
  3. Allergic Rhinitis: 4 people, 6.67%
  4. Hypersensitivity: 3 people, 5.00%
  5. Gallstones (stone formation by bile component): 3 people, 5.00%
  6. Pain: 3 people, 5.00%
  7. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 5.00%
  8. Kidney Infection: 2 people, 3.33%
  9. Gastric Ph Decreased: 2 people, 3.33%
  10. Back Pain: 2 people, 3.33%

* Approximation only. Some reports may have incomplete information.

Do you take Singulair and have Nephrotic syndrome?

Check whether Nephrotic syndrome is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

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How severe was Nephrotic syndrome and when was it recovered:

Expand to all the drugs that have ingredients of montelukast sodium:

Alternative drugs to, pros and cons of Singulair:

Common Singulair side effects:

Browse all side effects of Singulair:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Nephrotic syndrome treatments and more:

COVID vaccines that are related to Nephrotic syndrome:

Common drugs associated with Nephrotic syndrome:

All the drugs that are associated with Nephrotic syndrome:

Common conditions associated with Nephrotic syndrome:

All the conditions that are associated with Nephrotic syndrome:

How the study uses the data?

The study uses data from the FDA. It is based on montelukast sodium (the active ingredients of Singulair) and Singulair (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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