Solu-medrol and Appendicitis perforated - a phase IV clinical study of FDA data


Appendicitis perforated is found among people who take Solu-medrol, especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months.

The phase IV clinical study analyzes which people take Solu-medrol and have Appendicitis perforated. It is created by eHealthMe based on reports of 32,924 people who have side effects when taking Solu-medrol from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Oct, 01, 2022

32,924 people reported to have side effects when taking Solu-medrol.
Among them, 6 people (0.02%) have Appendicitis perforated.

What is Solu-medrol?

Solu-medrol has active ingredients of methylprednisolone sodium succinate. It is often used in multiple sclerosis. eHealthMe is studying from 33,068 Solu-medrol users for its effectiveness, alternative drugs and more.

What is Appendicitis perforated?

Appendicitis perforated (perforated appendicitis is a condition in which an inflamed appendix bursts) is found to be associated with 805 drugs and 502 conditions by eHealthMe.

Number of Solu-medrol and Appendicitis perforated reports submitted per year:

Could Solu-medrol cause Appendicitis perforated?

Time on Solu-medrol when people have Appendicitis perforated *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 100 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Appendicitis perforated when taking Solu-medrol *:

  • female: 100 %
  • male: 0.0 %

Age of people who have Appendicitis perforated when taking Solu-medrol *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 16.67 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 33.33 %
  • 60+: 50.0 %

Common drugs people take besides Solu-medrol *:

  1. Tylenol: 5 people, 83.33%
  2. Benadryl: 4 people, 66.67%
  3. Tegretol: 3 people, 50.00%
  4. Ocrevus: 3 people, 50.00%
  5. Phenergan: 1 person, 16.67%
  6. Cannabis: 1 person, 16.67%
  7. Cymbalta: 1 person, 16.67%
  8. Keflex: 1 person, 16.67%
  9. Methotrexate: 1 person, 16.67%
  10. Modafinil: 1 person, 16.67%

Common side effects people have besides Appendicitis perforated *:

  1. Fever: 4 people, 66.67%
  2. Gait Disturbance: 3 people, 50.00%
  3. Chills (felling of cold): 3 people, 50.00%
  4. Pain: 3 people, 50.00%
  5. Feeling Abnormal: 3 people, 50.00%
  6. Eye Irritation: 2 people, 33.33%
  7. Oropharyngeal Pain: 2 people, 33.33%
  8. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 16.67%
  9. Fungal Infection: 1 person, 16.67%
  10. Fatigue (feeling of tiredness): 1 person, 16.67%

Common conditions people have *:

  1. Pain: 4 people, 66.67%
  2. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 33.33%
  3. Vomiting In Pregnancy: 1 person, 16.67%
  4. Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 1 person, 16.67%
  5. Neuralgia (pain in one or more nerves): 1 person, 16.67%
  6. Nausea (feeling of having an urge to vomit): 1 person, 16.67%
  7. Migraine (headache): 1 person, 16.67%
  8. Itching: 1 person, 16.67%
  9. Indigestion: 1 person, 16.67%
  10. Headache (pain in head): 1 person, 16.67%

* Approximation only. Some reports may have incomplete information.

Do you take Solu-medrol and have Appendicitis perforated?

Check whether Appendicitis perforated is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Appendicitis perforated and when was it recovered:

Expand to all the drugs that have ingredients of methylprednisolone sodium succinate:

Alternative drugs to, pros and cons of Solu-medrol:

Common Solu-medrol side effects:

Browse all side effects of Solu-medrol:

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Appendicitis perforated treatments and more:

COVID vaccines that are related to Appendicitis perforated:

Common drugs associated with Appendicitis perforated:

All the drugs that are associated with Appendicitis perforated:

Common conditions associated with Appendicitis perforated:

All the conditions that are associated with Appendicitis perforated:

How the study uses the data?

The study uses data from the FDA. It is based on methylprednisolone sodium succinate (the active ingredients of Solu-medrol) and Solu-medrol (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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