Spironolactone and Rheumatic fever - a phase IV clinical study of FDA data


Rheumatic fever is found among people who take Spironolactone, especially for people who are female, 60+ old.

The phase IV clinical study analyzes which people take Spironolactone and have Rheumatic fever. It is created by eHealthMe based on reports of 98,724 people who have side effects when taking Spironolactone from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Oct, 01, 2022

98,724 people reported to have side effects when taking Spironolactone.
Among them, 10 people (0.01%) have Rheumatic fever.

What is Spironolactone?

Spironolactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 101,935 Spironolactone users for its effectiveness, alternative drugs and more.

What is Rheumatic fever?

Rheumatic fever (an inflammatory disease that occurs following a streptococcus pyogenes infection) is found to be associated with 404 drugs and 203 conditions by eHealthMe.

Number of Spironolactone and Rheumatic fever reports submitted per year:

Could Spironolactone cause Rheumatic fever?

Gender of people who have Rheumatic fever when taking Spironolactone *:

  • female: 100 %
  • male: 0.0 %

Age of people who have Rheumatic fever when taking Spironolactone *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 0.0 %
  • 60+: 100 %

Common drugs people take besides Spironolactone *:

  1. Zometa: 10 people, 100.00%
  2. Lipitor: 10 people, 100.00%
  3. Aldactone: 10 people, 100.00%
  4. Aranesp: 10 people, 100.00%
  5. Benicar: 10 people, 100.00%
  6. Coreg: 10 people, 100.00%
  7. Digoxin: 10 people, 100.00%
  8. Diovan: 10 people, 100.00%
  9. Vicodin: 10 people, 100.00%
  10. Lanoxin: 10 people, 100.00%

Common side effects people have besides Rheumatic fever *:

  1. Wax Blockage: 10 people, 100.00%
  2. Decreased Interest: 10 people, 100.00%
  3. Intervertebral Disc Degeneration (spinal disc degeneration): 10 people, 100.00%
  4. Impaired Work Ability: 10 people, 100.00%
  5. Hypotension (abnormally low blood pressure): 10 people, 100.00%
  6. Hyperlipidaemia (presence of excess lipids in the blood): 10 people, 100.00%
  7. Hepatic Neoplasm (liver tumour): 10 people, 100.00%
  8. Urinary Tract Infection: 10 people, 100.00%
  9. Headache (pain in head): 10 people, 100.00%
  10. Groin Pain: 10 people, 100.00%

Common conditions people have *:

  1. Breast Cancer Metastatic: 10 people, 100.00%
  2. Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 1 person, 10.00%
  3. Multiple Allergies (allergy to multiple agents): 1 person, 10.00%
  4. Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 10.00%
  5. Back Pain: 1 person, 10.00%

* Approximation only. Some reports may have incomplete information.

Do you take Spironolactone and have Rheumatic fever?

Check whether Rheumatic fever is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Rheumatic fever and when was it recovered:

Expand to all the drugs that have ingredients of spironolactone:

Alternative drugs to, pros and cons of Spironolactone:

Common Spironolactone side effects:

Browse all side effects of Spironolactone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Rheumatic fever treatments and more:

COVID vaccines that are related to Rheumatic fever:

Common drugs associated with Rheumatic fever:

All the drugs that are associated with Rheumatic fever:

Common conditions associated with Rheumatic fever:

All the conditions that are associated with Rheumatic fever:

How the study uses the data?

The study uses data from the FDA. It is based on spironolactone (the active ingredients of Spironolactone) and Spironolactone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe: