Suboxone and Dementia - a phase IV clinical study of FDA data


Dementia is found among people who take Suboxone, especially for people who are male, 60+ old.

The phase IV clinical study analyzes which people take Suboxone and have Dementia. It is created by eHealthMe based on reports of 26,417 people who have side effects when taking Suboxone from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Oct, 03, 2022

26,417 people reported to have side effects when taking Suboxone.
Among them, 18 people (0.07%) have Dementia.

What is Suboxone?

Suboxone has active ingredients of buprenorphine hydrochloride; naloxone hydrochloride. It is often used in opiate withdrawal. eHealthMe is studying from 29,125 Suboxone users for its effectiveness, alternative drugs and more.

What is Dementia?

Dementia (madness) is found to be associated with 2,291 drugs and 1,659 conditions by eHealthMe.

Number of Suboxone and Dementia reports submitted per year:

Could Suboxone cause Dementia?

Gender of people who have Dementia when taking Suboxone *:

  • female: 25 %
  • male: 75 %

Age of people who have Dementia when taking Suboxone *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 14.29 %
  • 40-49: 0.0 %
  • 50-59: 28.57 %
  • 60+: 57.14 %

Common drugs people take besides Suboxone *:

  1. Lipitor: 6 people, 33.33%
  2. Abilify: 4 people, 22.22%
  3. Oxycontin: 4 people, 22.22%
  4. Hydrocodone Bitartrate And Acetaminophen: 4 people, 22.22%
  5. Avinza: 3 people, 16.67%
  6. Vicodin: 3 people, 16.67%
  7. Percocet: 3 people, 16.67%
  8. Soma: 2 people, 11.11%
  9. Norco: 2 people, 11.11%
  10. Ms Contin: 2 people, 11.11%

Common side effects people have besides Dementia *:

  1. Cardiac Disorder: 8 people, 44.44%
  2. Depression: 7 people, 38.89%
  3. Back Pain: 6 people, 33.33%
  4. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 5 people, 27.78%
  5. Confusion: 5 people, 27.78%
  6. Drug Dependence: 5 people, 27.78%
  7. Sleep Apnea Syndrome: 5 people, 27.78%
  8. Alcoholism (problems with alcohol): 5 people, 27.78%
  9. Erection Problems: 3 people, 16.67%
  10. Speech Impairment (Adult) (inability to speak (adult)): 2 people, 11.11%

Common conditions people have *:

  1. Pain: 2 people, 11.11%
  2. Renal Cell Carcinoma (a kidney cancer): 1 person, 5.56%
  3. Malignant Urinary Tract Neoplasm (cancer tumour of urinary tract organs): 1 person, 5.56%
  4. Drug Dependence: 1 person, 5.56%
  5. Bipolar Disorder (mood disorder): 1 person, 5.56%
  6. Back Pain: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Suboxone and have Dementia?

Check whether Dementia is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Dementia and when was it recovered:

Expand to all the drugs that have ingredients of buprenorphine hydrochloride; naloxone hydrochloride:

Alternative drugs to, pros and cons of Suboxone:

Common Suboxone side effects:

Browse all side effects of Suboxone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Dementia treatments and more:

COVID vaccines that are related to Dementia:

Common drugs associated with Dementia:

All the drugs that are associated with Dementia:

Common conditions associated with Dementia:

All the conditions that are associated with Dementia:

How the study uses the data?

The study uses data from the FDA. It is based on buprenorphine hydrochloride; naloxone hydrochloride (the active ingredients of Suboxone) and Suboxone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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