Symbicort and Joint instability - a phase IV clinical study of FDA data


Joint instability is found among people who take Symbicort, especially for people who are female, 50-59 old, have been taking the drug for < 1 month.

The phase IV clinical study analyzes which people take Symbicort and have Joint instability. It is created by eHealthMe based on reports of 88,623 people who have side effects when taking Symbicort from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse drug outcomes and monitor effectiveness. Our original studies have been referenced on 600+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Most recently, phase IV clinial trails for COVID 19 vaccines have been added, check here.

On Aug, 03, 2022

88,623 people reported to have side effects when taking Symbicort.
Among them, 8 people (0.01%) have Joint instability.

What is Symbicort?

Symbicort has active ingredients of budesonide; formoterol fumarate dihydrate. It is often used in asthma. eHealthMe is studying from 90,531 Symbicort users for its effectiveness, alternative drugs and more.

What is Joint instability?

Joint instability (a condition in which the joints aren't sufficiently supported) is found to be associated with 491 drugs and 312 conditions by eHealthMe.

Number of Symbicort and Joint instability reports submitted per year:

Could Symbicort cause Joint instability?

Time on Symbicort when people have Joint instability *:

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Joint instability when taking Symbicort *:

  • female: 62.5 %
  • male: 37.5 %

Age of people who have Joint instability when taking Symbicort *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 25 %
  • 50-59: 50 %
  • 60+: 25 %

Common drugs people take besides Symbicort *:

  1. Zyrtec: 5 people, 62.50%
  2. Tylenol: 5 people, 62.50%
  3. Humira: 3 people, 37.50%
  4. Simvastatin: 2 people, 25.00%
  5. Xarelto: 2 people, 25.00%
  6. Xanax: 2 people, 25.00%
  7. Allegra: 2 people, 25.00%
  8. Epipen: 2 people, 25.00%
  9. Xolair: 2 people, 25.00%
  10. Betadine: 2 people, 25.00%

Common side effects people have besides Joint instability *:

  1. Joint Pain: 5 people, 62.50%
  2. Fall: 4 people, 50.00%
  3. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 3 people, 37.50%
  4. Muscle Disorder (muscle disease): 3 people, 37.50%
  5. Pain In Extremity: 3 people, 37.50%
  6. Back Pain: 3 people, 37.50%
  7. Balance Disorder: 3 people, 37.50%
  8. Wheezing (a high-pitched whistling sound made while you breath): 2 people, 25.00%
  9. Weight Loss: 2 people, 25.00%
  10. Laryngeal Oedema (swelling of larynx): 2 people, 25.00%

Common conditions people have *:

  1. High Blood Cholesterol: 4 people, 50.00%
  2. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 37.50%
  3. Hypersensitivity: 3 people, 37.50%
  4. Immune System Disorder: 2 people, 25.00%
  5. Breathing Difficulty: 2 people, 25.00%
  6. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 25.00%
  7. Respiratory Disorder (respiratory disease): 2 people, 25.00%
  8. Cough: 2 people, 25.00%
  9. Diabetes: 2 people, 25.00%
  10. Joint Pain: 2 people, 25.00%

* Approximation only. Some reports may have incomplete information.

Do you take Symbicort and have Joint instability?

Check whether Joint instability is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Alternative drugs to, pros and cons of Symbicort:

Joint instability treatments and more:

COVID vaccines that are related to Joint instability:

How severe was Joint instability and when was it recovered:

Expand to all the drugs that have ingredients of budesonide; formoterol fumarate dihydrate:

Common drugs associated with Joint instability:

All the drugs that are associated with Joint instability:

Common conditions associated with Joint instability:

All the conditions that are associated with Joint instability:

How the study uses the data?

The study uses data from the FDA. It is based on budesonide; formoterol fumarate dihydrate (the active ingredients of Symbicort) and Symbicort (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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