Symmetrel and Ards (acute respiratory distress syndrome) - a phase IV clinical study of FDA data

Summary:

Ards (acute respiratory distress syndrome) is found among people who take Symmetrel, especially for people who are male, 60+ old, have been taking the drug for < 1 month.

The phase IV clinical study analyzes which people take Symmetrel and have Ards (acute respiratory distress syndrome). It is created by eHealthMe based on reports of 3,138 people who have side effects when taking Symmetrel from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On May, 26, 2023

3,138 people reported to have side effects when taking Symmetrel.
Among them, 22 people (0.7%) have Ards (acute respiratory distress syndrome).

What is Symmetrel?

Symmetrel has active ingredients of amantadine hydrochloride. It is often used in parkinson's disease. eHealthMe is studying from 3,165 Symmetrel users for its effectiveness, alternative drugs and more.

What is Ards (acute respiratory distress syndrome)?

Ards (acute respiratory distress syndrome) (sudden failure of the respiratory (breathing) system) is found to be associated with 2,541 drugs and 2,381 conditions by eHealthMe.

Number of Symmetrel and Ards (acute respiratory distress syndrome) reports submitted per year:

Could Symmetrel cause Ards (acute respiratory distress syndrome)?

Time on Symmetrel when people have Ards (acute respiratory distress syndrome) *:

Gender of people who have Ards (acute respiratory distress syndrome) when taking Symmetrel *:

female: 22.73 %
male: 77.27 %

Age of people who have Ards (acute respiratory distress syndrome) when taking Symmetrel *:

Common drugs people take besides Symmetrel *:

Common side effects people have besides Ards (acute respiratory distress syndrome) *:

Pneumonia: 8 people, 36.36%
Fever: 7 people, 31.82%
Pneumonia Aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree): 7 people, 31.82%
Sepsis (a severe blood infection that can lead to organ failure and death): 5 people, 22.73%
Muscle Rigidity (muscle stiffness): 4 people, 18.18%
Nausea And Vomiting: 4 people, 18.18%
Abdominal Distension: 3 people, 13.64%
Neuroleptic Malignant Syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents): 3 people, 13.64%
Constipation: 3 people, 13.64%
Pulmonary Oedema (fluid accumulation in the lungs): 3 people, 13.64%

Common conditions people have *:

Gastric Cancer (stomach cancer): 2 people, 9.09%
The Flu (the flu is caused by an influenza virus): 1 person, 4.55%
Pneumonia: 1 person, 4.55%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 1 person, 4.55%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Symmetrel and have Ards (acute respiratory distress syndrome)?

Check whether Ards (acute respiratory distress syndrome) is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Yang Y, Teja S, Baig K, "Bilateral corneal edema associated with amantadine", Canadian Medical Association Journal, 2015 Oct .
Cattoni J, Parekh R, "Acute respiratory distress syndrome: A rare presentation of amantadine toxicity", The American journal of case reports, 2012 Jan .

Related studies

How severe was Ards (acute respiratory distress syndrome) and when was it recovered:

Ards (acute respiratory distress syndrome) in Symmetrel

Expand to all the drugs that have ingredients of amantadine hydrochloride:

Ards (acute respiratory distress syndrome) and drugs with ingredients of amantadine hydrochloride

Alternative drugs to, pros and cons of Symmetrel:

Symmetrel (3,165 reports)

Common Symmetrel side effects:

Browse all side effects of Symmetrel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Ards (acute respiratory distress syndrome) treatments and more:

Ards (acute respiratory distress syndrome) (23,538 reports)

COVID vaccines that are related to Ards (acute respiratory distress syndrome):

Common drugs associated with Ards (acute respiratory distress syndrome):

All the drugs that are associated with Ards (acute respiratory distress syndrome):

Ards (acute respiratory distress syndrome) (2,541 drugs)

Common conditions associated with Ards (acute respiratory distress syndrome):

Rheumatoid arthritis: 955 reports
High blood pressure: 751 reports
Pain: 464 reports
Multiple myeloma: 458 reports
Atrial fibrillation/flutter: 420 reports
Preventive health care: 382 reports
Depression: 330 reports

All the conditions that are associated with Ards (acute respiratory distress syndrome):

Ards (acute respiratory distress syndrome) (2,381 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on amantadine hydrochloride (the active ingredients of Symmetrel) and Symmetrel (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.