Synthroid and Urine discoloration - a phase IV clinical study of FDA data


Urine discoloration is found among people who take Synthroid, especially for people who are female, 60+ old.

The phase IV clinical study analyzes which people take Synthroid and have Urine discoloration. It is created by eHealthMe based on reports of 215,853 people who have side effects when taking Synthroid from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Oct, 01, 2022

215,853 people reported to have side effects when taking Synthroid.
Among them, 95 people (0.04%) have Urine discoloration.

What is Synthroid?

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 226,740 Synthroid users for its effectiveness, alternative drugs and more.

What is Urine discoloration?

Urine discoloration is found to be associated with 624 drugs and 65 conditions by eHealthMe.

Number of Synthroid and Urine discoloration reports submitted per year:

Could Synthroid cause Urine discoloration?

Gender of people who have Urine discoloration when taking Synthroid *:

  • female: 82.98 %
  • male: 17.02 %

Age of people who have Urine discoloration when taking Synthroid *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 1.08 %
  • 30-39: 3.23 %
  • 40-49: 13.98 %
  • 50-59: 24.73 %
  • 60+: 56.99 %

Common drugs people take besides Synthroid *:

  1. Rezulin: 22 people, 23.16%
  2. Zocor: 21 people, 22.11%
  3. Premarin: 16 people, 16.84%
  4. Lasix: 14 people, 14.74%
  5. Baycol: 11 people, 11.58%
  6. Glucophage: 11 people, 11.58%
  7. Zestril: 10 people, 10.53%
  8. Prevacid: 10 people, 10.53%
  9. Flonase: 9 people, 9.47%
  10. Lipitor: 8 people, 8.42%

Common side effects people have besides Urine discoloration *:

  1. Fatigue (feeling of tiredness): 39 people, 41.05%
  2. Nausea (feeling of having an urge to vomit): 37 people, 38.95%
  3. Liver Function Tests Nos Abnormal: 36 people, 37.89%
  4. Blood Bilirubin Increased: 20 people, 21.05%
  5. Weakness: 18 people, 18.95%
  6. Fever: 16 people, 16.84%
  7. Hepatic Necrosis (large portions of liver die off due to severe liver disease): 15 people, 15.79%
  8. Oedema Lower Limb (fluid collection in tissue of lower leg): 14 people, 14.74%
  9. Weight Decreased: 14 people, 14.74%
  10. Itching: 13 people, 13.68%

Common conditions people have *:

  1. Joint Pain: 1 person, 1.05%
  2. Fatigue (feeling of tiredness): 1 person, 1.05%

* Approximation only. Some reports may have incomplete information.

Do you take Synthroid and have Urine discoloration?

Check whether Urine discoloration is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Urine discoloration and when was it recovered:

Expand to all the drugs that have ingredients of levothyroxine sodium:

Alternative drugs to, pros and cons of Synthroid:

Common Synthroid side effects:

Browse all side effects of Synthroid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Urine discoloration treatments and more:

COVID vaccines that are related to Urine discoloration:

Common drugs associated with Urine discoloration:

All the drugs that are associated with Urine discoloration:

All the conditions that are associated with Urine discoloration:

How the study uses the data?

The study uses data from the FDA. It is based on levothyroxine sodium (the active ingredients of Synthroid) and Synthroid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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