Tacrolimus and Hypergammaglobulinaemia - a phase IV clinical study of FDA data


Hypergammaglobulinaemia is found among people who take Tacrolimus, especially for people who are female, 50-59 old.

The phase IV clinical study analyzes which people take Tacrolimus and have Hypergammaglobulinaemia. It is created by eHealthMe based on reports of 90,919 people who have side effects when taking Tacrolimus from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Aug, 12, 2022

90,919 people reported to have side effects when taking Tacrolimus.
Among them, 13 people (0.01%) have Hypergammaglobulinaemia.

What is Tacrolimus?

Tacrolimus has active ingredients of tacrolimus. It is often used in kidney transplant. eHealthMe is studying from 78,844 Tacrolimus users for its effectiveness, alternative drugs and more.

What is Hypergammaglobulinaemia?

Hypergammaglobulinaemia (elevated levels of gamma globulin) is found to be associated with 405 drugs and 184 conditions by eHealthMe.

Number of Tacrolimus and Hypergammaglobulinaemia reports submitted per year:

Could Tacrolimus cause Hypergammaglobulinaemia?

Gender of people who have Hypergammaglobulinaemia when taking Tacrolimus *:

  • female: 66.67 %
  • male: 33.33 %

Age of people who have Hypergammaglobulinaemia when taking Tacrolimus *:

  • 0-1: 0.0 %
  • 2-9: 8.33 %
  • 10-19: 8.33 %
  • 20-29: 0.0 %
  • 30-39: 16.67 %
  • 40-49: 8.33 %
  • 50-59: 41.67 %
  • 60+: 16.67 %

Common drugs people take besides Tacrolimus *:

  1. Prednisolone: 4 people, 30.77%
  2. Mycophenolate Mofetil: 3 people, 23.08%
  3. Rifabutin: 1 person, 7.69%
  4. Pyrazinamide: 1 person, 7.69%
  5. Prednisone: 1 person, 7.69%
  6. Pantoprazole: 1 person, 7.69%
  7. Mycophenolic Acid: 1 person, 7.69%
  8. Metoprolol Succinate: 1 person, 7.69%
  9. Isoniazid: 1 person, 7.69%
  10. Cyclosporine: 1 person, 7.69%

Common side effects people have besides Hypergammaglobulinaemia *:

  1. Memory Loss: 6 people, 46.15%
  2. Dizziness: 5 people, 38.46%
  3. Progressive Multifocal Leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells): 5 people, 38.46%
  4. Mood Swings (an extreme or rapid change in mood): 5 people, 38.46%
  5. Eye Movements - Uncontrollable: 5 people, 38.46%
  6. Nausea (feeling of having an urge to vomit): 5 people, 38.46%
  7. Drowsiness: 5 people, 38.46%
  8. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 5 people, 38.46%
  9. Pleocytosis (increased cell count): 5 people, 38.46%
  10. Diplopia (double vision): 5 people, 38.46%

Common conditions people have *:

  1. Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 3 people, 23.08%
  2. Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 1 person, 7.69%
  3. Immunodeficiency Disorders: 1 person, 7.69%
  4. Herpes Simplex (herpes simplex is a common viral infection): 1 person, 7.69%
  5. Bone Marrow Conditioning Regimen: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Tacrolimus and have Hypergammaglobulinaemia?

Check whether Hypergammaglobulinaemia is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Hypergammaglobulinaemia and when was it recovered:

Expand to all the drugs that have ingredients of tacrolimus:

Alternative drugs to, pros and cons of Tacrolimus:

Common Tacrolimus side effects:

Browse all side effects of Tacrolimus:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Hypergammaglobulinaemia treatments and more:

COVID vaccines that are related to Hypergammaglobulinaemia:

All the drugs that are associated with Hypergammaglobulinaemia:

All the conditions that are associated with Hypergammaglobulinaemia:

How the study uses the data?

The study uses data from the FDA. It is based on tacrolimus (the active ingredients of Tacrolimus) and Tacrolimus (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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