Tacrolimus and Leishmaniasis - a phase IV clinical study of FDA data


Leishmaniasis is found among people who take Tacrolimus, especially for people who are male, 40-49 old, have been taking the drug for 5 - 10 years.

The phase IV clinical study analyzes which people take Tacrolimus and have Leishmaniasis. It is created by eHealthMe based on reports of 90,919 people who have side effects when taking Tacrolimus from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Feb, 07, 2023

90,919 people reported to have side effects when taking Tacrolimus.
Among them, 16 people (0.02%) have Leishmaniasis.

What is Tacrolimus?

Tacrolimus has active ingredients of tacrolimus. It is often used in kidney transplant. eHealthMe is studying from 91,217 Tacrolimus users for its effectiveness, alternative drugs and more.

What is Leishmaniasis?

Leishmaniasis (a disease caused by protozoan parasites that belong to the genus leishmania) is found to be associated with 152 drugs and 151 conditions by eHealthMe.

Number of Tacrolimus and Leishmaniasis reports submitted per year:

Could Tacrolimus cause Leishmaniasis?

Time on Tacrolimus when people have Leishmaniasis *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 100 %
  • 10+ years: 0.0 %

Gender of people who have Leishmaniasis when taking Tacrolimus *:

  • female: 26.67 %
  • male: 73.33 %

Age of people who have Leishmaniasis when taking Tacrolimus *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 66.67 %
  • 50-59: 20.0 %
  • 60+: 13.33 %

Common drugs people take besides Tacrolimus *:

  1. Voriconazole: 3 people, 18.75%
  2. Mycophenolate Mofetil: 3 people, 18.75%
  3. Micafungin: 3 people, 18.75%
  4. Levofloxacin: 3 people, 18.75%
  5. Cyclophosphamide: 3 people, 18.75%
  6. Acyclovir: 3 people, 18.75%
  7. Prednisone: 1 person, 6.25%
  8. Methylprednisolone: 1 person, 6.25%
  9. Isoniazid: 1 person, 6.25%
  10. Ganciclovir: 1 person, 6.25%

Common side effects people have besides Leishmaniasis *:

  1. Pseudopolyp (projecting masses of scar tissue that develop from granulation tissue during the healing phase in repeated cycle of ulceration): 9 people, 56.25%
  2. Lymphocytic Infiltration (lymphocyte deposition): 9 people, 56.25%
  3. Malabsorption (a state arising from abnormality in absorption of food nutrients across the gastrointestinal (gi) tract): 9 people, 56.25%
  4. Gastrointestinal Disorder (functional problems of gastrointestinal tract): 9 people, 56.25%
  5. Visceral Leishmaniasis (black fever): 4 people, 25.00%
  6. Toxoplasmosis (a parasitic disease caused by the protozoan toxoplasma gondii): 3 people, 18.75%
  7. Mucormycosis (a rare infection caused by organisms that belong to a group of fungi called mucoromycotina): 3 people, 18.75%
  8. Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 3 people, 18.75%
  9. Hepatomegaly (abnormal enlargement of the liver): 3 people, 18.75%
  10. Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 3 people, 18.75%

Common conditions people have *:

  1. Iga Nephropathy (kidney disease- condition prevents the kidneys from filtering waste): 7 people, 43.75%
  2. Immunodeficiency Disorders: 4 people, 25.00%
  3. Crohn's Disease (condition that causes inflammation of the gastrointestinal tract): 3 people, 18.75%
  4. Visceral Leishmaniasis (black fever): 1 person, 6.25%
  5. Human Herpesvirus 6 Infection: 1 person, 6.25%
  6. Engraftment Syndrome (inflammatory condition during neutrophil recovery after hematopoietic stem cell transplantation): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Tacrolimus and have Leishmaniasis?

Check whether Leishmaniasis is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Leishmaniasis and when was it recovered:

Expand to all the drugs that have ingredients of tacrolimus:

Alternative drugs to, pros and cons of Tacrolimus:

Common Tacrolimus side effects:

Browse all side effects of Tacrolimus:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Leishmaniasis treatments and more:

COVID vaccines that are related to Leishmaniasis:

All the drugs that are associated with Leishmaniasis:

All the conditions that are associated with Leishmaniasis:

How the study uses the data?

The study uses data from the FDA. It is based on tacrolimus (the active ingredients of Tacrolimus) and Tacrolimus (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe: