Tacrolimus and Parkinson's disease - a phase IV clinical study of FDA data
Parkinson's disease is found among people who take Tacrolimus, especially for people who are male, 60+ old, have been taking the drug for 2 - 5 years.
The phase IV clinical study analyzes which people take Tacrolimus and have Parkinson's disease. It is created by eHealthMe based on reports of 105,108 people who have side effects when taking Tacrolimus from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
105,108 people reported to have side effects when taking Tacrolimus.
Among them, 61 people (0.06%) have Parkinson's disease.
What is Tacrolimus?
Tacrolimus has active ingredients of tacrolimus. It is often used in kidney transplant. eHealthMe is studying from 105,424 Tacrolimus users for its effectiveness, alternative drugs and more.
What is Parkinson's disease?
Parkinson's disease is found to be associated with 2,263 drugs and 1,545 conditions by eHealthMe.
Number of Tacrolimus and Parkinson's disease reports submitted per year:
Time on Tacrolimus when people have Parkinson's disease *:
- < 1 month: 21.43 %
- 1 - 6 months: 35.71 %
- 6 - 12 months: 0.0 %
- 1 - 2 years: 0.0 %
- 2 - 5 years: 42.86 %
- 5 - 10 years: 0.0 %
- 10+ years: 0.0 %
Gender of people who have Parkinson's disease when taking Tacrolimus *:
- female: 42.11 %
- male: 57.89 %
Age of people who have Parkinson's disease when taking Tacrolimus *:
- 0-1: 0.0 %
- 2-9: 3.92 %
- 10-19: 1.96 %
- 20-29: 1.96 %
- 30-39: 0.0 %
- 40-49: 15.69 %
- 50-59: 33.33 %
- 60+: 43.14 %
Common drugs people take besides Tacrolimus *:
- Mycophenolate Mofetil: 9 people, 14.75%
- Prednisolone: 8 people, 13.11%
- Cyclosporine: 5 people, 8.20%
- Irbesartan: 5 people, 8.20%
- Lipitor: 4 people, 6.56%
- Insulin: 4 people, 6.56%
- Paracetamol: 4 people, 6.56%
- Ciclosporin: 4 people, 6.56%
- Vitamin D3: 3 people, 4.92%
- Atenolol: 3 people, 4.92%
Common side effects people have besides Parkinson's disease *:
- Tremor (trembling or shaking movements in one or more parts of your body): 15 people, 24.59%
- Muscle Rigidity (muscle stiffness): 11 people, 18.03%
- Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system): 7 people, 11.48%
- Freezing Phenomenon: 6 people, 9.84%
- Anhedonia (inability to experience pleasure from activities usually found enjoyable): 6 people, 9.84%
- Fall: 6 people, 9.84%
- Encephalopathy (functioning of the brain is affected by some agent or condition): 5 people, 8.20%
- Peripheral Sensory Neuropathy (damage to one or more of your peripheral nerves): 5 people, 8.20%
- Weight Decreased: 5 people, 8.20%
- Nausea And Vomiting: 5 people, 8.20%
Common conditions people have *:
- Lupus Nephritis (a chronic inflammatory autoimmune disorder that may affect kidney tissue): 7 people, 11.48%
- Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 5 people, 8.20%
- Immunodeficiency Disorders: 4 people, 6.56%
- Squamous Cell Carcinoma Of Skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin): 3 people, 4.92%
- Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 4.92%
- Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 2 people, 3.28%
- Cytomegalovirus Test Positive: 2 people, 3.28%
- Urinary Incontinence (inability to control the flow of urine and involuntary urination): 1 person, 1.64%
- Transplant Rejection (a transplant material is not worked): 1 person, 1.64%
- Gout (uric acid crystals building up in the body): 1 person, 1.64%
* Approximation only. Some reports may have incomplete information.
Do you take Tacrolimus and have Parkinson's disease?Check whether Parkinson's disease is associated with a drug or a condition
How to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related publications that referenced our studies
- Woulfe JM, Gray MT, Gray DA, Munoz DG, Middeldorp JM, "Hypothesis: a role for EBV-induced molecular mimicry in Parkinson's disease", Parkinsonism & related disorders, 2014 Jul .
How severe was Parkinson's disease and when was it recovered:
Expand to all the drugs that have ingredients of tacrolimus:
Alternative drugs to, pros and cons of Tacrolimus:
- Tacrolimus (105,424 reports)
Common Tacrolimus side effects:
- Drug ineffective: 5,839 reports
- Fever: 4,305 reports
- Diarrhea: 4,213 reports
- Pneumonia: 3,300 reports
- Transplant rejection (a transplant material is not worked): 3,112 reports
- Sepsis (a severe blood infection that can lead to organ failure and death): 2,428 reports
- High blood pressure: 2,335 reports
Browse all side effects of Tacrolimus:a b c d e f g h i j k l m n o p q r s t u v w x y z
Parkinson's disease treatments and more:
- Parkinson's disease (140,925 reports)
COVID vaccines that are related to Parkinson's disease:
- Parkinson's disease in Moderna COVID Vaccine
- Parkinson's disease in Pfizer BioNTech Covid Vaccine
- Parkinson's disease in Johnson and Johnson Covid Vaccine
Common drugs associated with Parkinson's disease:
- Sinemet: 1,834 reports
- Nuplazid: 1,323 reports
- Aspirin: 1,276 reports
- Metoclopramide: 1,069 reports
- Clopra: 1,069 reports
- Abilify: 870 reports
- Risperidone: 790 reports
- Omeprazole: 781 reports
- Clonazepam: 749 reports
- Loraz: 748 reports
All the drugs that are associated with Parkinson's disease:
- Parkinson's disease (2,263 drugs)
Common conditions associated with Parkinson's disease:
- Depression: 1,536 reports
- High blood pressure: 1,074 reports
- Schizophrenia: 904 reports
- Hallucinations: 789 reports
All the conditions that are associated with Parkinson's disease:
- Parkinson's disease (1,545 conditions)
How the study uses the data?
The study uses data from the FDA. It is based on tacrolimus (the active ingredients of Tacrolimus) and Tacrolimus (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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