Temazepam and Gastrointestinal inflammation - a phase IV clinical study of FDA data

• Temazepam (36,525 reports)

• Abasia (inability to walk): 101 reports
• Abdominal discomfort: 333 reports
• Abdominal distension: 360 reports
• Abdominal pain: 697 reports
• Abdominal pain upper: 582 reports
• Abnormal behavior: 273 reports
• Abnormal dreams: 165 reports
• Abscess (pus): 123 reports
• Accidental overdose (therapeutic agent): 310 reports
• Acne (skin problems that cause pimples): 108 reports
• Activities of daily living impaired: 123 reports
• Acute kidney failure: 859 reports
• Acute myocardial infarction (acute heart attack): 125 reports
• Aggression: 306 reports
• Agitation (state of anxiety or nervous excitement): 583 reports
• Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 454 reports
• Alanine aminotransferase increased: 210 reports
• Anaemia (lack of blood): 980 reports
• Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 122 reports
• Anger: 140 reports
• Anhedonia (inability to experience pleasure from activities usually found enjoyable): 313 reports
• Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight): 115 reports
• Appetite - decreased (decreased appetite occurs when you have a reduced desire to eat): 799 reports
• Appetite - increased (increased appetite is when you want to eat much more often or in larger quantities than your body requires): 108 reports
• Arrhythmias (irregular heartbeat): 567 reports
• Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery): 113 reports
• Arthritis (form of joint disorder that involves inflammation of one or more joints): 422 reports
• Arthropathy: 173 reports
• Ascites (accumulation of fluid in the abdominal cavity): 117 reports
• Aseptic necrosis (the death of bone tissue due to a lack of blood supply): 182 reports
• Aspartate aminotransferase increased: 168 reports
• Asthma: 407 reports
• Atelectasis (partial or complete collapse of the lung): 250 reports
• Atherosclerosis (disorder of the arteries): 134 reports
• Atrial fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 559 reports
• Back pain: 1,249 reports
• Balance disorder: 359 reports
• Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure): 111 reports
• Blood bilirubin increased: 102 reports
• Blood creatine phosphokinase increased: 139 reports
• Blood creatinine increased: 262 reports
• Blood glucose decreased: 117 reports
• Blood glucose increased: 312 reports
• Blood potassium decreased: 159 reports
• Blood pressure systolic increased: 131 reports
• Blood sodium decreased: 136 reports
• Blood urea increased: 129 reports
• Bone disorder: 364 reports
• Bone pain: 263 reports
• Bradycardia (abnormally slow heart action): 295 reports
• Breast cancer: 131 reports
• Breast infection: 103 reports
• Breathing difficulty: 1,888 reports
• Breathing - slowed or stopped: 251 reports
• Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 372 reports
• Burning sensation: 255 reports
• Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder): 188 reports
• Cardiac arrest: 523 reports
• Cardiac disorder: 217 reports
• Cardiac failure: 222 reports
• Cardiac failure congestive: 543 reports
• Cardiomyopathy (weakening of the heart muscle): 169 reports
• Cardio-respiratory arrest (sudden dysfunction of heart and lungs): 290 reports
• Cataract (clouding of the lens inside the eye): 228 reports
• Celiac disease - sprue (a disease of the small intestine): 129 reports
• Cellulitis (infection under the skin): 286 reports
• Chest pain: 1,073 reports
• Chills (felling of cold): 409 reports
• Chronic kidney disease: 806 reports
• Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe): 372 reports
• Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving): 207 reports
• Colitis (inflammation of colon): 139 reports
• Completed suicide (act of taking one's own life): 1,374 reports
• Condition: 616 reports
• Confusion: 309 reports
• Confusional state: 889 reports
• Consciousness - decreased: 217 reports
• Constipation: 1,108 reports
• Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 315 reports
• Coronary heart disease (narrowing or blockage of the coronary arteries): 212 reports
• Cough: 885 reports
• Coughing up blood: 114 reports
• Crohn's disease (condition that causes inflammation of the gastrointestinal tract): 103 reports
• Crying: 125 reports
• Cuts and puncture wounds: 123 reports
• Death: 1,537 reports
• Decreased interest: 117 reports
• Deep venous thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 273 reports
• Dehydration (dryness resulting from the removal of water): 1,001 reports
• Delirium (wild excitement): 206 reports
• Dental caries: 173 reports
• Depressed level of consciousness: 311 reports
• Depressed mood: 227 reports
• Depression: 1,372 reports
• Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it): 102 reports
• Diabetes: 478 reports
• Diabetes mellitus inadequate control: 121 reports
• Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies): 113 reports
• Diarrhea: 1,714 reports
• Diplopia (double vision): 118 reports
• Disability: 118 reports
• Disease progression: 185 reports
• Disturbance in attention: 242 reports
• Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall): 133 reports
• Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body): 125 reports
• Dizziness: 1,692 reports
• Drowsiness: 990 reports
• Drug abuse and dependence: 646 reports
• Drug dependence: 304 reports
• Drug effect decreased: 223 reports
• Drug hypersensitivity: 342 reports
• Drug ineffective: 2,078 reports
• Drug intolerance (drug sensitivity): 125 reports
• Drug level increased: 107 reports
• Drug toxicity: 400 reports
• Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 309 reports
• Dry eyes (lack of adequate tears): 117 reports
• Dry mouth: 308 reports
• Dry skin: 128 reports
• Dyskinesia (abnormality or impairment of voluntary movement): 195 reports
• Dyspnea exertional: 177 reports
• Eating disorder: 118 reports
• Electrocardiogram qt prolonged: 152 reports
• Emotional disorder: 165 reports
• Emotional distress: 399 reports
• Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs): 109 reports
• Encephalopathy (functioning of the brain is affected by some agent or condition): 130 reports
• Enlarged heart: 216 reports
• Erection problems: 143 reports
• Exostosis (formation of new bone on the surface of a bone): 166 reports
• Eye pain: 131 reports
• Fainting (loss of consciousness and postural tone): 444 reports
• Fall: 1,658 reports
• Fatigue (feeling of tiredness): 2,651 reports
• Fear: 137 reports
• Febrile neutropenia (fever with reduced white blood cells): 177 reports
• Feeling hot: 154 reports
• Fever: 1,166 reports
• Fibromyalgia (a long-term condition which causes pain all over the body): 116 reports
• Flatulence (flatus expelled through the anus): 156 reports
• Fluid retention (an abnormal accumulation of fluid in the blood): 281 reports
• Food allergy: 114 reports
• Full blood count decreased: 112 reports
• Gait disturbance: 729 reports
• Gallstones (stone formation by bile component): 171 reports
• Gastric ulcer (stomach ulcer): 264 reports
• Gastritis (inflammation of stomach): 212 reports
• Gastroesophageal reflux disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 488 reports
• Gastrointestinal disorder (functional problems of gastrointestinal tract): 140 reports
• Gastrointestinal haemorrhage (bleeding gastrointestinal tract): 415 reports
• General physical health deterioration (weak health status): 375 reports
• Haematemesis (vomiting of blood): 165 reports
• Haematochezia (passage of stools containing blood): 116 reports
• Haematocrit decreased: 149 reports
• Haematoma (collection of blood outside the blood vessels): 114 reports
• Haematuria (presence of blood in urine): 182 reports
• Haemoglobin decreased: 483 reports
• Haemorrhage (bleeding): 285 reports
• Haemorrhoids (a swollen vein or group of veins in the region of the anus): 156 reports
• Hair loss: 453 reports
• Hallucinations (sensations that appear real but are created by your mind): 325 reports
• Hallucination, visual (seeing things that aren't there): 107 reports
• Headache (pain in head): 1,801 reports
• Head injury: 635 reports
• Hearing loss: 104 reports
• Heart attack: 511 reports
• Heart palpitations (feelings or sensations that your heart is pounding or racing): 329 reports
• Heart rate decreased: 170 reports
• Heart rate increased: 375 reports
• Heart rate irregular: 128 reports
• Hemiparesis (weakness on one side of the body): 110 reports
• Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue): 116 reports
• Hepatic enzyme increased: 260 reports
• Hepatic failure (liver failure): 132 reports
• Hepatic steatosis (fatty liver disease): 212 reports
• Hepatomegaly (abnormal enlargement of the liver): 127 reports
• Herpes zoster: 182 reports
• Hiatal hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 203 reports
• High blood cholesterol: 328 reports
• High blood pressure: 1,238 reports
• Hip fracture: 137 reports
• Hoarseness or changing voice: 196 reports
• Hospitalisation: 158 reports
• Hot flush (sudden feelings of heat): 177 reports
• Hyperglycemia (high blood sugar): 154 reports
• Hyperhidrosis (abnormally increased sweating): 640 reports
• Hyperkalemia (damage to or disease of the kidney): 234 reports
• Hyperlipidaemia (presence of excess lipids in the blood): 174 reports
• Hypersensitivity: 355 reports
• Hypoaesthesia (reduced sense of touch or sensation): 599 reports
• Hypoglycemia (low blood sugar): 206 reports
• Hypokalemia (low potassium): 278 reports
• Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 383 reports
• Hypophagia (reduced food intake): 142 reports
• Hypotension (abnormally low blood pressure): 1,226 reports
• Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions): 107 reports
• Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 142 reports
• Ill-defined disorder: 108 reports
• Immunodeficiency: 174 reports
• Impaired healing: 234 reports
• Indigestion: 439 reports
• Infection: 417 reports
• Inflammation: 131 reports
• Influenza like illness: 219 reports
• Injection site pain: 247 reports
• Injury: 572 reports
• Insomnia (sleeplessness): 1,531 reports
• Intentional overdose: 270 reports
• International normalised ratio increased: 209 reports
• Interstitial lung disease: 110 reports
• Intervertebral disc degeneration (spinal disc degeneration): 184 reports
• Intervertebral disc protrusion (spinal disc protrusion): 275 reports
• Intestinal obstruction: 139 reports
• Irritability: 260 reports
• Itching: 655 reports
• Jaundice - yellow skin (a yellowish pigmentation of the skin): 166 reports
• Jaw disorder (jaw disease): 125 reports
• Joint pain: 1,055 reports
• Joint swelling: 498 reports
• Kidney stones: 201 reports
• Leukopenia (less number of white blood cells in blood): 172 reports
• Limb discomfort (discomfort in leg): 124 reports
• Loss of consciousness: 657 reports
• Lower respiratory tract infection: 213 reports
• Low tissue oxygen: 270 reports
• Lung disorder (lung disease): 107 reports
• Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung): 137 reports
• Lung neoplasm malignant (cancer tumour of lung): 132 reports
• Lymph follicular hypertrophy (an increase in the size of the lymph node follicles): 190 reports
• Malaise (a feeling of general discomfort or uneasiness): 1,284 reports
• Malignant neoplasm progression (cancer tumour came back): 148 reports
• Memory loss: 948 reports
• Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 377 reports
• Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition): 189 reports
• Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 257 reports
• Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 200 reports
• Metastases to bone (cancer spreads to bone): 210 reports
• Metastases to spine (cancer spreads to spine): 125 reports
• Migraine (headache): 329 reports
• Mitral valve incompetence (inefficient heart valve): 136 reports
• Mobility decreased (ability to move is reduced): 170 reports
• Mood swings (an extreme or rapid change in mood): 212 reports
• Mouth ulcers: 125 reports
• Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness): 122 reports
• Multi-organ failure (multisystem organ failure): 105 reports
• Multiple drug overdose: 170 reports
• Multiple myeloma (cancer of the plasma cells): 182 reports
• Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 118 reports
• Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 218 reports
• Muscle aches (muscle pain): 432 reports
• Muscle spasms (muscle contraction): 574 reports
• Muscle twitching: 130 reports
• Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves): 114 reports
• Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 286 reports
• Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 289 reports
• Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased): 119 reports
• Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 168 reports
• Nasopharyngitis (inflammation of the nasopharynx): 318 reports
• Nausea (feeling of having an urge to vomit): 2,268 reports
• Nausea and vomiting: 1,377 reports
• Neck pain: 271 reports
• Neoplasm malignant (cancer tumour): 152 reports
• Nephrogenic anaemia (anaemia due to kidney disease): 147 reports
• Nervousness: 253 reports
• Neuralgia (pain in one or more nerves): 176 reports
• Neuropathy peripheral (surface nerve damage): 466 reports
• Neutrophil count increased (excess than normal number of neutrophil a type of blood cell): 118 reports
• Nightmares (unpleasant dreams): 197 reports
• Night sweats (sweating in night): 129 reports
• Nosebleed (bleeding from nose): 326 reports
• Oedema (fluid collection in tissue): 291 reports
• Oedema peripheral (superficial swelling): 749 reports
• Oral pain: 120 reports
• Oropharyngeal pain: 239 reports
• Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up): 117 reports
• Osteoarthritis (a joint disease caused by cartilage loss in a joint): 435 reports
• Osteomyelitis (infection of bone): 242 reports
• Osteonecrosis of jaw (death of bone of jaw): 398 reports
• Osteopenia (a condition where bone mineral density is lower than normal): 169 reports
• Osteoporosis (bones weak and more likely to break): 283 reports
• Overdose: 1,065 reports
• Oxygen saturation decreased: 230 reports
• Pain: 2,190 reports
• Pain in extremity: 1,064 reports
• Pain in jaw: 255 reports
• Paleness (unusual lightness of skin colour): 106 reports
• Pancreatitis (inflammation of pancreas): 213 reports
• Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 217 reports
• Panic disorder: 227 reports
• Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 587 reports
• Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur): 126 reports
• Parkinson's disease: 105 reports
• Pericardial effusion (fluid around the heart): 102 reports
• Peripheral coldness: 101 reports
• Pleural effusion (water on the lungs): 362 reports
• Pneumonia: 1,585 reports
• Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree): 137 reports
• Poisoning: 168 reports
• Pollakiuria (abnormally frequent passage of relatively small quantities or urine): 222 reports
• Poor quality sleep: 153 reports
• Presyncope: 103 reports
• Productive cough: 197 reports
• Psoriasis (immune-mediated disease that affects the skin): 228 reports
• Psychotic disorder: 223 reports
• Pulmonary congestion (congestion in the lungs): 227 reports
• Pulmonary embolism (blockage of the main artery of the lung): 389 reports
• Pulmonary hypertension (increase in blood pressure in the lung artery): 113 reports
• Pulmonary oedema (fluid accumulation in the lungs): 338 reports
• Pulse: 116 reports
• Rash erythematous (redness of the skin): 219 reports
• Rashes (redness): 1,184 reports
• Rash pruritic (redness with itching): 122 reports
• Rectal haemorrhage (bleeding from anus): 209 reports
• Red blood cell count decreased: 107 reports
• Renal cyst (kidney cyst): 132 reports
• Renal disorder (kidney disease): 134 reports
• Renal failure acute (rapid kidney dysfunction): 403 reports
• Renal failure chronic (long lasting kidney dysfunction): 129 reports
• Renal impairment (severely reduced kidney function): 294 reports
• Renal injury (kidney injury): 277 reports
• Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 334 reports
• Respiratory depression (respiration has a rate below 12 breaths): 161 reports
• Respiratory distress (difficulty in breathing): 108 reports
• Restless leg syndrome (a powerful urge to move your legs): 141 reports
• Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down): 158 reports
• Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints): 380 reports
• Rib fracture: 209 reports
• Road traffic accident: 202 reports
• Scar: 133 reports
• Sedation: 258 reports
• Seizures (abnormal excessive or synchronous neuronal activity in the brain): 241 reports
• Sepsis (a severe blood infection that can lead to organ failure and death): 554 reports
• Septic shock (shock due to blood infection): 103 reports
• Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time): 129 reports
• Sinusitis (inflammation of sinus): 416 reports
• Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node): 137 reports
• Skin blushing/flushing (a sudden reddening of the face, neck): 290 reports
• Skin discoloration: 122 reports
• Skin ulcer: 125 reports
• Sleep apnea syndrome: 212 reports
• Sleep disorder: 357 reports
• Sleep walking (walking during sleep): 134 reports
• Speech disorder: 181 reports
• Speech impairment (adult) (inability to speak (adult)): 483 reports
• Spinal osteoarthritis (joint cartilage loss in spine): 260 reports
• Stable angina (a constant chest pain): 115 reports
• Staphylococcal infection (an infection with staphylococcus bacteria): 139 reports
• Stomatitis (inflammation of mucous membrane of mouth): 154 reports
• Stress and anxiety: 1,942 reports
• Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 363 reports
• Suicidal ideation: 541 reports
• Suicide attempt: 476 reports
• Surgery: 153 reports
• Swallowing difficulty: 539 reports
• Swelling: 215 reports
• Swelling face: 173 reports
• Taste - impaired: 257 reports
• Temperature regulation disorder (body is unable to maintain temperature): 173 reports
• Tenderness (pain or discomfort when an affected area is touched): 109 reports
• The flu (the flu is caused by an influenza virus): 299 reports
• Therapeutic agent toxicity (poisoning by ability to cure substance): 102 reports
• Therapeutic response unexpected: 137 reports
• Thrombocytopenia (decrease of platelets in blood): 828 reports
• Thrombosis (formation of a blood clot inside a blood vessel): 182 reports
• Thyroid diseases: 146 reports
• Tinnitus (a ringing in the ears): 154 reports
• Tooth abscess (pus formation in tooth): 168 reports
• Toothaches (tooth pain): 155 reports
• Tooth disorder (tooth disease): 123 reports
• Tooth extraction: 137 reports
• Tooth loss: 118 reports
• Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow)): 145 reports
• Tremor (trembling or shaking movements in one or more parts of your body): 802 reports
• Tricuspid valve incompetence (inefficient heart valve): 123 reports
• Tumor: 155 reports
• Type 2 diabetes: 257 reports
• Unresponsive to stimuli: 214 reports
• Upper respiratory tract infection: 334 reports
• Urinary incontinence (inability to control the flow of urine and involuntary urination): 283 reports
• Urinary retention (the inability to completely or partially empty the bladder): 204 reports
• Urinary tract infection: 884 reports
• Urination - painful: 176 reports
• Urticaria (rash of round, red welts on the skin that itch intensely): 200 reports
• Vision blurred: 454 reports
• Visual acuity reduced (reduced clearness of vision): 120 reports
• Visual impairment: 224 reports
• Weakness: 1,780 reports
• Weight decreased: 1,142 reports
• Weight increased: 819 reports
• Weight loss: 177 reports
• Wheezing (a high-pitched whistling sound made while you breath): 211 reports
• White blood cell count decreased: 325 reports
• White blood cell count increased: 294 reports
• Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance): 213 reports
• Wound: 109 reports

• Gastrointestinal inflammation (7,706 reports)

• Amlodipine: 113 reports
• Aspirin: 187 reports
• Calcium: 154 reports
• Cyclophosphamide: 139 reports
• Enbrel: 126 reports
• Humira: 2,705 reports
• Ibu: 118 reports
• Ibuprofen: 125 reports
• Imuran: 166 reports
• Metformin: 113 reports
• Methotrexate: 461 reports
• Morphine: 111 reports
• Nexium: 135 reports
• Omeprazole: 285 reports
• Pantoprazole: 207 reports
• Pentasa: 133 reports
• Prednisone: 611 reports
• Remicade: 268 reports
• Synthroid: 127 reports
• Tramadol: 104 reports
• Tylenol: 121 reports
• Vitamin b12: 142 reports
• Vitamin d: 213 reports

All the drugs that are associated with Gastrointestinal inflammation:

• Gastrointestinal inflammation (772 drugs)

• Ankylosing spondylitis: 101 reports
• Blood pressure increased: 331 reports
• Crohn's disease: 2,655 reports
• Crohns disease: 2,655 reports
• Feeling uptight: 108 reports
• Gastroesophageal reflux disease: 144 reports
• Hbp: 350 reports
• High blood cholesterol: 123 reports
• High blood pressure: 350 reports
• Hyperlipidemia: 123 reports
• Hypertension: 350 reports
• Ileitis: 2,655 reports
• Inflammatory bowel disease - crohn's disease: 2,655 reports
• Lipid test: 130 reports
• Lipoprotein test: 123 reports
• Multiple sclerosis: 115 reports
• Pain: 224 reports
• Pain management: 224 reports
• Psoriatic arthropathy aggravated: 126 reports
• Rheumatoid arthritis: 327 reports
• Stress and anxiety: 108 reports
• Uc: 527 reports
• Ulcerative colitis: 527 reports

All the conditions that are associated with Gastrointestinal inflammation:

• Gastrointestinal inflammation (511 conditions)

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