Topiramate and Respiratory alkalosis - a phase IV clinical study of FDA data


Respiratory alkalosis is found among people who take Topiramate, especially for people who are female, 50-59 old, have been taking the drug for 2 - 5 years.

The phase IV clinical study analyzes which people take Topiramate and have Respiratory alkalosis. It is created by eHealthMe based on reports of 39,034 people who have side effects when taking Topiramate from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Aug, 16, 2022

39,034 people reported to have side effects when taking Topiramate.
Among them, 58 people (0.15%) have Respiratory alkalosis.

What is Topiramate?

Topiramate has active ingredients of topiramate. It is often used in migraine. eHealthMe is studying from 35,686 Topiramate users for its effectiveness, alternative drugs and more.

What is Respiratory alkalosis?

Respiratory alkalosis (elevated blood ph due to excess breathing) is found to be associated with 650 drugs and 396 conditions by eHealthMe.

Number of Topiramate and Respiratory alkalosis reports submitted per year:

Could Topiramate cause Respiratory alkalosis?

Time on Topiramate when people have Respiratory alkalosis *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 100 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Respiratory alkalosis when taking Topiramate *:

  • female: 74.07 %
  • male: 25.93 %

Age of people who have Respiratory alkalosis when taking Topiramate *:

  • 0-1: 1.92 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 28.85 %
  • 30-39: 13.46 %
  • 40-49: 19.23 %
  • 50-59: 36.54 %
  • 60+: 0.0 %

Common drugs people take besides Topiramate *:

  1. Naloxone: 20 people, 34.48%
  2. Clopidogrel: 18 people, 31.03%
  3. Advair Hfa: 17 people, 29.31%
  4. Escitalopram: 13 people, 22.41%
  5. Oxycodone: 9 people, 15.52%
  6. Ondansetron: 8 people, 13.79%
  7. Paracetamol: 7 people, 12.07%
  8. Gabapentin: 2 people, 3.45%
  9. Pyridostigmine Bromide: 2 people, 3.45%
  10. Metoprolol Tartrate: 2 people, 3.45%

Common side effects people have besides Respiratory alkalosis *:

  1. Metabolic Acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 26 people, 44.83%
  2. Depressed Level Of Consciousness: 25 people, 43.10%
  3. Confusional State: 24 people, 41.38%
  4. Irritability: 23 people, 39.66%
  5. Suicide Attempt: 22 people, 37.93%
  6. Apnea (temporary absence or cessation of breathing): 22 people, 37.93%
  7. Sinus Tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node): 22 people, 37.93%
  8. Overdose: 22 people, 37.93%
  9. Drowsiness: 22 people, 37.93%
  10. Electrocardiogram Qt Prolonged: 21 people, 36.21%

Common conditions people have *:

  1. Headache (pain in head): 15 people, 25.86%
  2. Suicide Attempt: 13 people, 22.41%
  3. Overdose: 12 people, 20.69%
  4. Neuralgia (pain in one or more nerves): 10 people, 17.24%
  5. Partial Seizures (seizures which affect only a part of the brain at onset): 8 people, 13.79%
  6. Nausea (feeling of having an urge to vomit): 8 people, 13.79%
  7. Abdominal Pain: 7 people, 12.07%
  8. Seizures (abnormal excessive or synchronous neuronal activity in the brain): 3 people, 5.17%
  9. Pseudotumor Cerebri (increased pressure within the brain in the absence of a tumour): 3 people, 5.17%
  10. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 1 person, 1.72%

* Approximation only. Some reports may have incomplete information.

Do you take Topiramate and have Respiratory alkalosis?

Check whether Respiratory alkalosis is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

How severe was Respiratory alkalosis and when was it recovered:

Expand to all the drugs that have ingredients of topiramate:

Alternative drugs to, pros and cons of Topiramate:

Common Topiramate side effects:

Browse all side effects of Topiramate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Respiratory alkalosis treatments and more:

COVID vaccines that are related to Respiratory alkalosis:

All the drugs that are associated with Respiratory alkalosis:

All the conditions that are associated with Respiratory alkalosis:

How the study uses the data?

The study uses data from the FDA. It is based on topiramate (the active ingredients of Topiramate) and Topiramate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe: