Toprol-xl and Gastrointestinal inflammation - a phase IV clinical study of FDA data


Gastrointestinal inflammation is found among people who take Toprol-xl, especially for people who are female, 50-59 old.

The phase IV clinical study analyzes which people take Toprol-xl and have Gastrointestinal inflammation. It is created by eHealthMe based on reports of 38,272 people who have side effects when taking Toprol-xl from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Aug, 16, 2022

38,272 people reported to have side effects when taking Toprol-xl.
Among them, 23 people (0.06%) have Gastrointestinal inflammation.

What is Toprol-xl?

Toprol-xl has active ingredients of metoprolol succinate. It is often used in high blood pressure. eHealthMe is studying from 40,546 Toprol-xl users for its effectiveness, alternative drugs and more.

What is Gastrointestinal inflammation?

Gastrointestinal inflammation (inflammation of stomach and intestine) is found to be associated with 772 drugs and 511 conditions by eHealthMe.

Number of Toprol-xl and Gastrointestinal inflammation reports submitted per year:

Could Toprol-xl cause Gastrointestinal inflammation?

Gender of people who have Gastrointestinal inflammation when taking Toprol-xl *:

  • female: 95.65 %
  • male: 4.35 %

Age of people who have Gastrointestinal inflammation when taking Toprol-xl *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 8.7 %
  • 40-49: 0.0 %
  • 50-59: 56.52 %
  • 60+: 34.78 %

Common drugs people take besides Toprol-xl *:

  1. Ambien: 15 people, 65.22%
  2. Neurontin: 15 people, 65.22%
  3. Cymbalta: 15 people, 65.22%
  4. Lasix: 13 people, 56.52%
  5. Zometa: 12 people, 52.17%
  6. Gabapentin: 12 people, 52.17%
  7. Norvasc: 12 people, 52.17%
  8. Ms Contin: 12 people, 52.17%
  9. Morphine: 12 people, 52.17%
  10. Methocarbamol: 12 people, 52.17%

Common side effects people have besides Gastrointestinal inflammation *:

  1. Diarrhea: 17 people, 73.91%
  2. Abdominal Pain: 16 people, 69.57%
  3. Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 14 people, 60.87%
  4. Nausea (feeling of having an urge to vomit): 14 people, 60.87%
  5. Nausea And Vomiting: 13 people, 56.52%
  6. Fever: 13 people, 56.52%
  7. Ilium Fracture: 12 people, 52.17%
  8. Haemorrhoids (a swollen vein or group of veins in the region of the anus): 12 people, 52.17%
  9. Foot Deformity (functional disability of foot): 12 people, 52.17%
  10. Gastritis (inflammation of stomach): 12 people, 52.17%

Common conditions people have *:

  1. Breast Cancer: 6 people, 26.09%
  2. Depression: 4 people, 17.39%
  3. Irritable Bowel Syndrome: 3 people, 13.04%
  4. Urinary Retention (the inability to completely or partially empty the bladder): 2 people, 8.70%
  5. Type 2 Diabetes: 2 people, 8.70%
  6. Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 2 people, 8.70%
  7. Bile Acid Malabsorption: 2 people, 8.70%
  8. Cardiac Failure Congestive: 2 people, 8.70%
  9. Crohn's Disease (condition that causes inflammation of the gastrointestinal tract): 2 people, 8.70%
  10. Diabetes: 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

Do you take Toprol-xl and have Gastrointestinal inflammation?

Check whether Gastrointestinal inflammation is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

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How severe was Gastrointestinal inflammation and when was it recovered:

Expand to all the drugs that have ingredients of metoprolol succinate:

Alternative drugs to, pros and cons of Toprol-xl:

Common Toprol-xl side effects:

Browse all side effects of Toprol-xl:

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Gastrointestinal inflammation treatments and more:

COVID vaccines that are related to Gastrointestinal inflammation:

Common drugs associated with Gastrointestinal inflammation:

All the drugs that are associated with Gastrointestinal inflammation:

Common conditions associated with Gastrointestinal inflammation:

All the conditions that are associated with Gastrointestinal inflammation:

How the study uses the data?

The study uses data from the FDA. It is based on metoprolol succinate (the active ingredients of Toprol-xl) and Toprol-xl (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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