Toprol-xl and Haemarthrosis - a phase IV clinical study of FDA data


Haemarthrosis is found among people who take Toprol-xl, especially for people who are female, 60+ old.

The phase IV clinical study analyzes which people take Toprol-xl and have Haemarthrosis. It is created by eHealthMe based on reports of 38,272 people who have side effects when taking Toprol-xl from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Mar, 28, 2023

38,272 people reported to have side effects when taking Toprol-xl.
Among them, 7 people (0.02%) have Haemarthrosis.

What is Toprol-xl?

Toprol-xl has active ingredients of metoprolol succinate. It is often used in high blood pressure. eHealthMe is studying from 40,593 Toprol-xl users for its effectiveness, alternative drugs and more.

What is Haemarthrosis?

Haemarthrosis (haemarthrosis is where blood is able to enter the joint capsule) is found to be associated with 1,179 drugs and 712 conditions by eHealthMe.

Number of Toprol-xl and Haemarthrosis reports submitted per year:

Could Toprol-xl cause Haemarthrosis?

Gender of people who have Haemarthrosis when taking Toprol-xl *:

  • female: 57.14 %
  • male: 42.86 %

Age of people who have Haemarthrosis when taking Toprol-xl *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 16.67 %
  • 50-59: 0.0 %
  • 60+: 83.33 %

Common drugs people take besides Toprol-xl *:

  1. Zocor: 5 people, 71.43%
  2. Lasix: 4 people, 57.14%
  3. Zometa: 3 people, 42.86%
  4. Prinivil: 3 people, 42.86%
  5. Flomax: 3 people, 42.86%
  6. Nexium: 3 people, 42.86%
  7. Coumadin: 3 people, 42.86%
  8. Norvasc: 3 people, 42.86%
  9. Baby Aspirin: 3 people, 42.86%
  10. Travatan: 3 people, 42.86%

Common side effects people have besides Haemarthrosis *:

  1. Joint Swelling: 5 people, 71.43%
  2. Joint Pain: 5 people, 71.43%
  3. Weakness: 4 people, 57.14%
  4. International Normalised Ratio Increased: 4 people, 57.14%
  5. Gait Disturbance: 4 people, 57.14%
  6. Pain: 4 people, 57.14%
  7. Monocyte Count Increased: 3 people, 42.86%
  8. Fall: 3 people, 42.86%
  9. Joint Range Of Motion Decreased (disease of joint movement): 3 people, 42.86%
  10. Joint Effusion (presence of extra fluid in joint covering): 3 people, 42.86%

Common conditions people have *:

  1. Osteoporosis (bones weak and more likely to break): 3 people, 42.86%
  2. Cardiomyopathy (weakening of the heart muscle): 3 people, 42.86%
  3. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 14.29%
  4. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 14.29%
  5. Embolism (obstruction of an artery, typically by a clot of blood or an air bubble): 1 person, 14.29%

* Approximation only. Some reports may have incomplete information.

Do you take Toprol-xl and have Haemarthrosis?

Check whether Haemarthrosis is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Haemarthrosis and when was it recovered:

Expand to all the drugs that have ingredients of metoprolol succinate:

Alternative drugs to, pros and cons of Toprol-xl:

Common Toprol-xl side effects:

Browse all side effects of Toprol-xl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Haemarthrosis treatments and more:

COVID vaccines that are related to Haemarthrosis:

Common drugs associated with Haemarthrosis:

All the drugs that are associated with Haemarthrosis:

Common conditions associated with Haemarthrosis:

All the conditions that are associated with Haemarthrosis:

How the study uses the data?

The study uses data from the FDA. It is based on metoprolol succinate (the active ingredients of Toprol-xl) and Toprol-xl (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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