Tpn and Chills - a phase IV clinical study of FDA data


Chills is found among people who take Tpn, especially for people who are female, 60+ old, have been taking the drug for 5 - 10 years.

The phase IV clinical study analyzes which people take Tpn and have Chills. It is created by eHealthMe based on reports of 1,036 people who have side effects when taking Tpn from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Nov, 27, 2022

1,036 people reported to have side effects when taking Tpn.
Among them, 16 people (1.54%) have Chills.

What is Tpn?

Tpn has active ingredients of niacinamide; pyridoxine hydrochloride; tyrosine. eHealthMe is studying from 1,047 Tpn users for its effectiveness, alternative drugs and more.

What is Chills?

Chills (felling of cold) is found to be associated with 3,585 drugs and 3,345 conditions by eHealthMe.

Number of Tpn and Chills reports submitted per year:

Could Tpn cause Chills?

Time on Tpn when people have Chills *:

  • < 1 month: 25 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 25 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 50 %
  • 10+ years: 0.0 %

Gender of people who have Chills when taking Tpn *:

  • female: 75 %
  • male: 25 %

Age of people who have Chills when taking Tpn *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 21.43 %
  • 20-29: 7.14 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 28.57 %
  • 60+: 42.86 %

Common drugs people take besides Tpn *:

  1. Zofran: 4 people, 25.00%
  2. Vitamin D: 4 people, 25.00%
  3. Vitamin A: 3 people, 18.75%
  4. Magnesium: 3 people, 18.75%
  5. Heparin: 3 people, 18.75%
  6. Codeine: 3 people, 18.75%
  7. Remicade: 3 people, 18.75%
  8. Vitamin B: 2 people, 12.50%
  9. Ativan: 2 people, 12.50%
  10. Vitamins: 2 people, 12.50%

Common side effects people have besides Chills *:

  1. Fever: 12 people, 75.00%
  2. Nausea (feeling of having an urge to vomit): 10 people, 62.50%
  3. Weight Increased: 6 people, 37.50%
  4. Fatigue (feeling of tiredness): 6 people, 37.50%
  5. Abdominal Distension: 5 people, 31.25%
  6. Malaise (a feeling of general discomfort or uneasiness): 5 people, 31.25%
  7. Nausea And Vomiting: 5 people, 31.25%
  8. Abdominal Pain: 5 people, 31.25%
  9. Flatulence (flatus expelled through the anus): 5 people, 31.25%
  10. Diarrhea: 5 people, 31.25%

Common conditions people have *:

  1. Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 9 people, 56.25%
  2. Insomnia (sleeplessness): 3 people, 18.75%
  3. Crohn's Disease (condition that causes inflammation of the gastrointestinal tract): 3 people, 18.75%
  4. Fungal Infection: 2 people, 12.50%
  5. Functional Gastrointestinal Disorder (functional problem in separate organs of gastrointestinal system): 2 people, 12.50%
  6. Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 12.50%
  7. Pain: 2 people, 12.50%
  8. Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve): 2 people, 12.50%
  9. Osteoporosis (bones weak and more likely to break): 1 person, 6.25%
  10. Oral Pain: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Tpn and have Chills?

Check whether Chills is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Chills and when was it recovered:

Expand to all the drugs that have ingredients of niacinamide; pyridoxine hydrochloride; tyrosine:

Alternative drugs to, pros and cons of Tpn:

  • Tpn (1,047 reports)

Common Tpn side effects:

Browse all side effects of Tpn:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Chills treatments and more:

COVID vaccines that are related to Chills:

Common drugs associated with Chills:

All the drugs that are associated with Chills:

Common conditions associated with Chills:

All the conditions that are associated with Chills:

How the study uses the data?

The study uses data from the FDA. It is based on niacinamide; pyridoxine hydrochloride; tyrosine (the active ingredients of Tpn) and Tpn (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe: