Tramadol and Type i hypersensitivity - a phase IV clinical study of FDA data


Type i hypersensitivity is found among people who take Tramadol, especially for people who are female, 60+ old, have been taking the drug for < 1 month.

The phase IV clinical study analyzes which people take Tramadol and have Type i hypersensitivity. It is created by eHealthMe based on reports of 194,214 people who have side effects when taking Tramadol from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Oct, 01, 2022

194,214 people reported to have side effects when taking Tramadol.
Among them, 26 people (0.01%) have Type i hypersensitivity.

What is Tramadol?

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 200,042 Tramadol users for its effectiveness, alternative drugs and more.

What is Type i hypersensitivity?

Type i hypersensitivity is found to be associated with 400 drugs and 266 conditions by eHealthMe.

Number of Tramadol and Type i hypersensitivity reports submitted per year:

Could Tramadol cause Type i hypersensitivity?

Time on Tramadol when people have Type i hypersensitivity *:

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Type i hypersensitivity when taking Tramadol *:

  • female: 80 %
  • male: 20 %

Age of people who have Type i hypersensitivity when taking Tramadol *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 8 %
  • 40-49: 0.0 %
  • 50-59: 4 %
  • 60+: 88 %

Common drugs people take besides Tramadol *:

  1. Celecoxib: 9 people, 34.62%
  2. Fentanyl: 9 people, 34.62%
  3. Pamidronate Disodium: 7 people, 26.92%
  4. Acetaminophen And Codeine Phosphate: 6 people, 23.08%
  5. Acetaminophen: 5 people, 19.23%
  6. Morphine Sulfate: 5 people, 19.23%
  7. Morphine: 4 people, 15.38%
  8. Eliquis: 3 people, 11.54%
  9. Paracetamol: 3 people, 11.54%
  10. Codeine Sulfate: 3 people, 11.54%

Common side effects people have besides Type i hypersensitivity *:

  1. Skin Blushing/flushing (a sudden reddening of the face, neck): 9 people, 34.62%
  2. Hyperhidrosis (abnormally increased sweating): 9 people, 34.62%
  3. Dizziness: 9 people, 34.62%
  4. Feeling Hot: 8 people, 30.77%
  5. Nausea And Vomiting: 4 people, 15.38%
  6. Itching: 4 people, 15.38%
  7. Drug Hypersensitivity: 3 people, 11.54%
  8. Tongue Oedema (swelling of tongue): 1 person, 3.85%
  9. Skin Test Positive: 1 person, 3.85%
  10. Rashes (redness): 1 person, 3.85%

Common conditions people have *:

  1. Cough: 8 people, 30.77%
  2. Breast Cancer Metastatic: 7 people, 26.92%
  3. Cancer Pain: 4 people, 15.38%
  4. Perioperative Analgesia: 3 people, 11.54%
  5. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 11.54%
  6. High Blood Pressure: 3 people, 11.54%
  7. General Anaesthesia: 3 people, 11.54%
  8. Renal Colic (renal pain): 2 people, 7.69%
  9. Intervertebral Disc Protrusion (spinal disc protrusion): 1 person, 3.85%
  10. Immune Tolerance Induction: 1 person, 3.85%

* Approximation only. Some reports may have incomplete information.

Do you take Tramadol and have Type i hypersensitivity?

Check whether Type i hypersensitivity is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

How severe was Type i hypersensitivity and when was it recovered:

Expand to all the drugs that have ingredients of tramadol hydrochloride:

Alternative drugs to, pros and cons of Tramadol:

Common Tramadol side effects:

Browse all side effects of Tramadol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Type i hypersensitivity treatments and more:

COVID vaccines that are related to Type i hypersensitivity:

Common drugs associated with Type i hypersensitivity:

All the drugs that are associated with Type i hypersensitivity:

All the conditions that are associated with Type i hypersensitivity:

How the study uses the data?

The study uses data from the FDA. It is based on tramadol hydrochloride (the active ingredients of Tramadol) and Tramadol (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe: