Tretinoin and Sicca syndrome - a phase IV clinical study of FDA data


We study 5,711 people who have side effects when taking Tretinoin. Sicca syndrome is found, especially among people who are female, 60+ old, also take Folic acid and have Osteoporosis.

The phase IV clinical study analyzes which people take Tretinoin and have Sicca syndrome. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 26, 2023

5,711 people reported to have side effects when taking Tretinoin.
Among them, 16 people (0.28%) have Sicca syndrome.

What is Tretinoin?

Tretinoin has active ingredients of tretinoin. It is used in acne. Currently, eHealthMe is studying from 5,835 Tretinoin users.

What is Sicca syndrome?

Sicca syndrome (the dryness of the eyes, mouth and other body parts is known as sicca syndrome) is found to be associated with 230 drugs and 102 conditions by eHealthMe. Currently, we are studying 261 people who have Sicca syndrome.

Number of Tretinoin and Sicca syndrome reports submitted per year:

Could Tretinoin cause Sicca syndrome?

Gender of people who have Sicca syndrome when taking Tretinoin *:

  • female: 100 %
  • male: 0.0 %

Age of people who have Sicca syndrome when taking Tretinoin *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 0.0 %
  • 60+: 100 %

Common drugs people take besides Tretinoin *:

  1. Zyrtec: 16 people, 100.00%
  2. Peridex: 16 people, 100.00%
  3. Metrolotion: 16 people, 100.00%
  4. Zometa: 16 people, 100.00%
  5. Macrobid: 16 people, 100.00%
  6. Lipitor: 16 people, 100.00%
  7. Levaquin: 16 people, 100.00%
  8. Lescol Xl: 16 people, 100.00%
  9. Fosamax: 16 people, 100.00%
  10. Folic Acid: 16 people, 100.00%

Common side effects people have besides Sicca syndrome *:

  1. Emotional Distress: 16 people, 100.00%
  2. Hypophagia (reduced food intake): 16 people, 100.00%
  3. Osteomyelitis (infection of bone): 16 people, 100.00%
  4. Osteolysis (dissolution of bone): 16 people, 100.00%
  5. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 16 people, 100.00%
  6. Heart Rate Irregular: 16 people, 100.00%
  7. Oropharyngeal Pain: 16 people, 100.00%
  8. Bone Disorder: 16 people, 100.00%
  9. Nodule (a growth of abnormal tissue): 16 people, 100.00%
  10. Breathing Difficulty: 16 people, 100.00%

Common conditions people have *:

  1. Osteoporosis (bones weak and more likely to break): 16 people, 100.00%

* Approximation only. Some reports may have incomplete information.

Do you take Tretinoin and have Sicca syndrome?

Check whether Sicca syndrome is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Tretinoin side effects by duration, gender and age:

Sicca syndrome treatments and more:

All the drugs that are associated with Sicca syndrome:

All the conditions that are associated with Sicca syndrome:

How the study uses the data?

The study uses data from the FDA. It is based on tretinoin (the active ingredients of Tretinoin) and Tretinoin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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