Tribenzor and Wakefulness - a phase IV clinical study of FDA data


Wakefulness is found among people who take Tribenzor, especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years.

The phase IV clinical study analyzes which people take Tribenzor and have Wakefulness. It is created by eHealthMe based on reports of 1,732 people who have side effects when taking Tribenzor from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Dec, 25, 2022

1,732 people reported to have side effects when taking Tribenzor.
Among them, 24 people (1.39%) have Wakefulness.

What is Tribenzor?

Tribenzor has active ingredients of amlodipine besylate; hydrochlorothiazide; olmesartan medoxomil. It is often used in high blood pressure. eHealthMe is studying from 1,800 Tribenzor users for its effectiveness, alternative drugs and more.

What is Wakefulness?

Wakefulness (not sleeping or not able to sleep) is found to be associated with 4,583 drugs and 5,020 conditions by eHealthMe.

Number of Tribenzor and Wakefulness reports submitted per year:

Could Tribenzor cause Wakefulness?

Time on Tribenzor when people have Wakefulness *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 100 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Wakefulness when taking Tribenzor *:

  • female: 57.14 %
  • male: 42.86 %

Age of people who have Wakefulness when taking Tribenzor *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 27.27 %
  • 60+: 72.73 %

Common drugs people take besides Tribenzor *:

  1. Benicar: 6 people, 25.00%
  2. Insulin: 4 people, 16.67%
  3. Welchol: 4 people, 16.67%
  4. Benicar Hct: 4 people, 16.67%
  5. Bystolic: 3 people, 12.50%
  6. Vitamin D3: 2 people, 8.33%
  7. Cymbalta: 2 people, 8.33%
  8. Cozaar: 2 people, 8.33%
  9. Coreg: 2 people, 8.33%
  10. Plavix: 2 people, 8.33%

Common side effects people have besides Wakefulness *:

  1. Stress And Anxiety: 14 people, 58.33%
  2. Dizziness: 11 people, 45.83%
  3. Depression: 9 people, 37.50%
  4. Hypotension (abnormally low blood pressure): 6 people, 25.00%
  5. Confusional State: 6 people, 25.00%
  6. Muscle Aches (muscle pain): 6 people, 25.00%
  7. Weakness: 5 people, 20.83%
  8. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 5 people, 20.83%
  9. Irritable Bowel Syndrome: 5 people, 20.83%
  10. Hypoglycemia (low blood sugar): 4 people, 16.67%

Common conditions people have *:

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 12.50%
  2. Stress And Anxiety: 2 people, 8.33%
  3. Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 8.33%
  4. Back Pain: 2 people, 8.33%
  5. Weight Loss: 1 person, 4.17%
  6. Weight Decreased: 1 person, 4.17%
  7. Type 2 Diabetes: 1 person, 4.17%
  8. Post Herpetic Neuralgia (neuralgia caused by the varicella zoster virus): 1 person, 4.17%
  9. Pneumonia: 1 person, 4.17%
  10. Pain: 1 person, 4.17%

* Approximation only. Some reports may have incomplete information.

Do you take Tribenzor and have Wakefulness?

Check whether Wakefulness is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Wakefulness and when was it recovered:

Expand to all the drugs that have ingredients of amlodipine besylate; hydrochlorothiazide; olmesartan medoxomil:

Alternative drugs to, pros and cons of Tribenzor:

Common Tribenzor side effects:

Browse all side effects of Tribenzor:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Wakefulness treatments and more:

COVID vaccines that are related to Wakefulness:

Common drugs associated with Wakefulness:

All the drugs that are associated with Wakefulness:

Common conditions associated with Wakefulness:

All the conditions that are associated with Wakefulness:

How the study uses the data?

The study uses data from the FDA. It is based on amlodipine besylate; hydrochlorothiazide; olmesartan medoxomil (the active ingredients of Tribenzor) and Tribenzor (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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