Tylenol and Sick sinus syndrome - a phase IV clinical study of FDA data

Summary:

Sick sinus syndrome is found among people who take Tylenol, especially for people who are female, 60+ old, have been taking the drug for 10+ years.

The phase IV clinical study analyzes which people take Tylenol and have Sick sinus syndrome. It is created by eHealthMe based on reports of 185,254 people who have side effects when taking Tylenol from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.



On Oct, 01, 2022

185,254 people reported to have side effects when taking Tylenol.
Among them, 100 people (0.05%) have Sick sinus syndrome.


What is Tylenol?

Tylenol has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 189,461 Tylenol users for its effectiveness, alternative drugs and more.

What is Sick sinus syndrome?

Sick sinus syndrome (a collection of heart rhythm disorders) is found to be associated with 1,303 drugs and 734 conditions by eHealthMe.

Number of Tylenol and Sick sinus syndrome reports submitted per year:

Could Tylenol cause Sick sinus syndrome?

Time on Tylenol when people have Sick sinus syndrome *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 100 %

Gender of people who have Sick sinus syndrome when taking Tylenol *:

  • female: 59.18 %
  • male: 40.82 %

Age of people who have Sick sinus syndrome when taking Tylenol *:

  • 0-1: 0.0 %
  • 2-9: 2.2 %
  • 10-19: 0.0 %
  • 20-29: 5.49 %
  • 30-39: 1.1 %
  • 40-49: 1.1 %
  • 50-59: 7.69 %
  • 60+: 82.42 %

Common drugs people take besides Tylenol *:

  1. Lasix: 30 people, 30.00%
  2. Coumadin: 29 people, 29.00%
  3. Zometa: 27 people, 27.00%
  4. Vioxx: 26 people, 26.00%
  5. Levaquin: 24 people, 24.00%
  6. Aspirin: 23 people, 23.00%
  7. Toprol-Xl: 23 people, 23.00%
  8. Prilosec: 21 people, 21.00%
  9. Ambien: 20 people, 20.00%
  10. Aredia: 20 people, 20.00%

Common side effects people have besides Sick sinus syndrome *:

  1. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 51 people, 51.00%
  2. Stress And Anxiety: 41 people, 41.00%
  3. Anaemia (lack of blood): 38 people, 38.00%
  4. High Blood Pressure: 36 people, 36.00%
  5. Cardiac Failure Congestive: 36 people, 36.00%
  6. Dizziness: 34 people, 34.00%
  7. Injury: 34 people, 34.00%
  8. Fatigue (feeling of tiredness): 33 people, 33.00%
  9. Weakness: 30 people, 30.00%
  10. Osteomyelitis (infection of bone): 30 people, 30.00%

Common conditions people have *:

  1. Metastases To Bone (cancer spreads to bone): 10 people, 10.00%
  2. Constipation: 6 people, 6.00%
  3. Paget's Disease (disorder that involves abnormal bone destruction and regrowth, which results in deformity): 6 people, 6.00%
  4. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 5 people, 5.00%
  5. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 4 people, 4.00%
  6. High Blood Pressure: 4 people, 4.00%
  7. Multiple Myeloma (cancer of the plasma cells): 4 people, 4.00%
  8. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 3.00%
  9. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 3.00%
  10. Back Pain: 3 people, 3.00%

* Approximation only. Some reports may have incomplete information.

Do you take Tylenol and have Sick sinus syndrome?

Check whether Sick sinus syndrome is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.



Related studies

How severe was Sick sinus syndrome and when was it recovered:

Expand to all the drugs that have ingredients of acetaminophen:

Alternative drugs to, pros and cons of Tylenol:

Common Tylenol side effects:

Browse all side effects of Tylenol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sick sinus syndrome treatments and more:

COVID vaccines that are related to Sick sinus syndrome:

Common drugs associated with Sick sinus syndrome:

All the drugs that are associated with Sick sinus syndrome:

Common conditions associated with Sick sinus syndrome:

All the conditions that are associated with Sick sinus syndrome:

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen (the active ingredients of Tylenol) and Tylenol (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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