Valproic acid and Dupuytren's contracture - a phase IV clinical study of FDA data

• Valproic acid (27,203 reports)

• Abdominal distension: 175 reports
• Abdominal pain: 265 reports
• Abdominal pain upper: 135 reports
• Abnormal behavior: 360 reports
• Abortion spontaneous (naturally occurring miscarriage): 155 reports
• Acute hepatic failure: 148 reports
• Acute kidney failure: 191 reports
• Aggression: 572 reports
• Agitation (state of anxiety or nervous excitement): 751 reports
• Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 610 reports
• Alanine aminotransferase increased: 304 reports
• Altered state of consciousness (altered state of mind): 175 reports
• Ammonia increased: 275 reports
• Anaemia (lack of blood): 274 reports
• Anticonvulsant drug level increased: 108 reports
• Apathy: 109 reports
• Appetite - decreased (decreased appetite occurs when you have a reduced desire to eat): 318 reports
• Arrhythmias (irregular heartbeat): 466 reports
• Aspartate aminotransferase increased: 307 reports
• Back pain: 141 reports
• Balance disorder: 203 reports
• Bleeding disorders: 119 reports
• Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure): 118 reports
• Blood creatine phosphokinase increased: 350 reports
• Blood creatinine increased: 140 reports
• Blood glucose increased: 119 reports
• Bradycardia (abnormally slow heart action): 179 reports
• Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain): 172 reports
• Breathing difficulty: 356 reports
• Breathing - slowed or stopped: 176 reports
• Cardiac arrest: 419 reports
• Cardiac failure: 101 reports
• Cardio-respiratory arrest (sudden dysfunction of heart and lungs): 327 reports
• Catatonia (unresponsive to external stimuli): 163 reports
• Chest pain: 196 reports
• Chills (felling of cold): 150 reports
• Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving): 350 reports
• Completed suicide (act of taking one's own life): 1,388 reports
• Condition: 519 reports
• Confusion: 326 reports
• Confusional state: 516 reports
• Consciousness - decreased: 642 reports
• Constipation: 219 reports
• Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 783 reports
• Cough: 159 reports
• C-reactive protein increased: 137 reports
• Death: 732 reports
• Dehydration (dryness resulting from the removal of water): 224 reports
• Delirium (wild excitement): 332 reports
• Delusion (a false belief or opinion): 160 reports
• Depressed level of consciousness: 556 reports
• Depressed mood: 219 reports
• Depression: 977 reports
• Developmental delay: 115 reports
• Diabetes: 160 reports
• Diarrhea: 391 reports
• Diplopia (double vision): 124 reports
• Disturbance in attention: 223 reports
• Dizziness: 560 reports
• Drowsiness: 1,122 reports
• Drug abuse and dependence: 242 reports
• Drug exposure during pregnancy: 242 reports
• Drug hypersensitivity: 183 reports
• Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications): 153 reports
• Drug ineffective: 2,291 reports
• Drug intolerance (drug sensitivity): 137 reports
• Drug level decreased: 142 reports
• Drug level increased: 353 reports
• Drug resistance (reduction in effectiveness of a drug): 254 reports
• Drug toxicity: 262 reports
• Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 128 reports
• Dyskinesia (abnormality or impairment of voluntary movement): 264 reports
• Dysmorphism (difference of body structure that is suggestive of a congenital disorder): 193 reports
• Electrocardiogram qt prolonged: 304 reports
• Encephalopathy (functioning of the brain is affected by some agent or condition): 341 reports
• Eosinophilia (eosinophil count in the peripheral blood exceeds): 141 reports
• Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 577 reports
• Erythema multiforme (a type of hypersensitivity reaction): 408 reports
• Extrapyramidal disorder (involuntary muscle spasms in the face and neck): 239 reports
• Fainting (loss of consciousness and postural tone): 191 reports
• Fall: 537 reports
• Fatigue (feeling of tiredness): 897 reports
• Fever: 1,064 reports
• Foetal anticonvulsant syndrome (malformations and developmental delay in children due to intake of anticonvulsant drugs in pregnancy): 240 reports
• Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 788 reports
• Gait disturbance: 428 reports
• Gamma-glutamyltransferase increased: 159 reports
• General physical health deterioration (weak health status): 218 reports
• Grand mal convulsion (a type of generalized seizure that affects the entire brain): 218 reports
• Haemoglobin decreased: 262 reports
• Haemorrhage (bleeding): 112 reports
• Hair loss: 184 reports
• Hallucination, auditory (perceiving sounds without auditory stimulus): 152 reports
• Hallucinations (sensations that appear real but are created by your mind): 185 reports
• Hallucination, visual (seeing things that aren't there): 119 reports
• Headache (pain in head): 413 reports
• Head injury: 189 reports
• Heart rate increased: 153 reports
• Hepatic enzyme increased: 146 reports
• Hepatic failure (liver failure): 256 reports
• Hepatitis (inflammation of the liver): 102 reports
• Hepatotoxicity (chemical-driven liver damage): 226 reports
• High blood cholesterol: 106 reports
• High blood pressure: 367 reports
• Hyperammonaemia: 593 reports
• Hyperammonaemic encephalopathy (excess of ammonia in the blood, disorder or disease of the brain): 424 reports
• Hyperhidrosis (abnormally increased sweating): 178 reports
• Hyperkalemia (damage to or disease of the kidney): 109 reports
• Hypernatraemia (an abnormally high plasma concentration of sodium ions): 156 reports
• Hypersensitivity: 126 reports
• Hypoglycemia (low blood sugar): 177 reports
• Hypokalemia (low potassium): 119 reports
• Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 291 reports
• Hypotension (abnormally low blood pressure): 813 reports
• Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions): 238 reports
• Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 109 reports
• Hypotonia (low muscle tone): 121 reports
• Infection: 152 reports
• Insomnia (sleeplessness): 418 reports
• Intentional overdose: 295 reports
• International normalised ratio increased: 107 reports
• Intestinal ischaemia (decreased supply of oxygenated blood to the intestines): 146 reports
• Intestinal obstruction: 120 reports
• Irritability: 305 reports
• Itching: 179 reports
• Joint pain: 137 reports
• Lactic acidosis (low ph in body tissues): 111 reports
• Leukocytosis (increased white blood cells): 150 reports
• Leukopenia (less number of white blood cells in blood): 298 reports
• Loss of consciousness: 383 reports
• Malaise (a feeling of general discomfort or uneasiness): 417 reports
• Mania (a state of abnormally elevated or irritable mood): 224 reports
• Maternal drugs affecting foetus (chemical affecting the baby before birth taken by mother): 127 reports
• Maternal exposure during pregnancy (use of substance during pregnancy): 237 reports
• Memory loss: 319 reports
• Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 107 reports
• Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition): 160 reports
• Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 258 reports
• Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 342 reports
• Mood swings (an extreme or rapid change in mood): 161 reports
• Movement - uncontrolled or slow: 154 reports
• Movement - uncoordinated: 257 reports
• Multi-organ failure (multisystem organ failure): 135 reports
• Multiple drug overdose: 115 reports
• Multiple-drug resistance: 187 reports
• Muscle aches (muscle pain): 108 reports
• Muscle rigidity (muscle stiffness): 195 reports
• Muscle spasms (muscle contraction): 111 reports
• Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 139 reports
• Myocarditis (inflammation of heart muscle myocardium): 117 reports
• Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles): 170 reports
• Nausea (feeling of having an urge to vomit): 628 reports
• Nausea and vomiting: 753 reports
• Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents): 481 reports
• Neutrophil count decreased (less than normal number of neutrophil a type of blood cell): 124 reports
• Oedema peripheral (superficial swelling): 173 reports
• Overdose: 920 reports
• Oxygen saturation decreased: 119 reports
• Pain: 301 reports
• Pain in extremity: 129 reports
• Pancreatitis (inflammation of pancreas): 197 reports
• Pancreatitis acute (sudden inflammation of pancreas): 163 reports
• Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 176 reports
• Parkinson's disease: 317 reports
• Partial seizures (seizures which affect only a part of the brain at onset): 120 reports
• Petit mal epilepsy (absence seizure): 203 reports
• Pleural effusion (water on the lungs): 167 reports
• Pneumonia: 796 reports
• Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree): 264 reports
• Poisoning: 154 reports
• Psychomotor hyperactivity (feelings of extreme restlessness): 187 reports
• Psychotic disorder: 418 reports
• Pulmonary embolism (blockage of the main artery of the lung): 107 reports
• Pulmonary oedema (fluid accumulation in the lungs): 108 reports
• Rashes (redness): 587 reports
• Rash maculo-papular (red area on the skin that is covered with small confluent bumps): 179 reports
• Renal failure acute (rapid kidney dysfunction): 127 reports
• Renal impairment (severely reduced kidney function): 130 reports
• Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 289 reports
• Respiratory depression (respiration has a rate below 12 breaths): 144 reports
• Respiratory distress (difficulty in breathing): 125 reports
• Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down): 304 reports
• Salivary hypersecretion (excess saliva secretion): 212 reports
• Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 155 reports
• Sedation: 382 reports
• Seizures (abnormal excessive or synchronous neuronal activity in the brain): 1,249 reports
• Sepsis (a severe blood infection that can lead to organ failure and death): 305 reports
• Septic shock (shock due to blood infection): 114 reports
• Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time): 115 reports
• Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin): 156 reports
• Sleep disorder: 197 reports
• Sopor (sleep): 112 reports
• Speech disorder: 295 reports
• Speech impairment (adult) (inability to speak (adult)): 424 reports
• Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 626 reports
• Stress and anxiety: 546 reports
• Suicidal ideation: 283 reports
• Suicide attempt: 370 reports
• Swallowing difficulty: 214 reports
• Therapeutic response decreased (less preventive response): 122 reports
• Thrombocytopenia (decrease of platelets in blood): 949 reports
• Toxic encephalopathy (a degenerative neurologic disorder caused by exposure to toxic substances): 101 reports
• Transaminases increased: 116 reports
• Tremor (trembling or shaking movements in one or more parts of your body): 642 reports
• Type 2 diabetes: 112 reports
• Unresponsive to stimuli: 186 reports
• Urinary incontinence (inability to control the flow of urine and involuntary urination): 158 reports
• Urinary tract infection: 246 reports
• Vision blurred: 148 reports
• Weakness: 581 reports
• Weight decreased: 312 reports
• Weight increased: 520 reports
• White blood cell count decreased: 270 reports
• White blood cell count increased: 234 reports
• Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance): 101 reports

• Dupuytren's contracture (2,031 reports)

All the drugs that are associated with Dupuytren's contracture:

• Dupuytren's contracture (445 drugs)

All the conditions that are associated with Dupuytren's contracture:

• Dupuytren's contracture (208 conditions)

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