Valproic acid and Jaundice - yellow skin - a phase IV clinical study of FDA data


Jaundice - yellow skin is found among people who take Valproic acid, especially for people who are female, 20-29 old, have been taking the drug for < 1 month.

The phase IV clinical study analyzes which people take Valproic acid and have Jaundice - yellow skin. It is created by eHealthMe based on reports of 30,749 people who have side effects when taking Valproic acid from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Nov, 30, 2022

30,749 people reported to have side effects when taking Valproic acid.
Among them, 53 people (0.17%) have Jaundice - yellow skin.

What is Valproic acid?

Valproic acid has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 31,097 Valproic acid users for its effectiveness, alternative drugs and more.

What is Jaundice - yellow skin?

Jaundice - yellow skin (a yellowish pigmentation of the skin) is found to be associated with 2,884 drugs and 2,828 conditions by eHealthMe.

Number of Valproic acid and Jaundice - yellow skin reports submitted per year:

Could Valproic acid cause Jaundice - yellow skin?

Time on Valproic acid when people have Jaundice - yellow skin *:

  • < 1 month: 50 %
  • 1 - 6 months: 50 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Jaundice - yellow skin when taking Valproic acid *:

  • female: 60.38 %
  • male: 39.62 %

Age of people who have Jaundice - yellow skin when taking Valproic acid *:

  • 0-1: 14.58 %
  • 2-9: 16.67 %
  • 10-19: 12.5 %
  • 20-29: 29.17 %
  • 30-39: 16.67 %
  • 40-49: 4.17 %
  • 50-59: 2.08 %
  • 60+: 4.17 %

Common drugs people take besides Valproic acid *:

  1. Phenytoin: 5 people, 9.43%
  2. Clonazepam: 4 people, 7.55%
  3. Acetaminophen: 3 people, 5.66%
  4. Levetiracetam: 3 people, 5.66%
  5. Carbamazepine: 3 people, 5.66%
  6. Diazepam: 3 people, 5.66%
  7. Acyclovir: 2 people, 3.77%
  8. Flumazenil: 2 people, 3.77%
  9. Trileptal: 2 people, 3.77%
  10. Lamotrigine: 2 people, 3.77%

Common side effects people have besides Jaundice - yellow skin *:

  1. Alanine Aminotransferase Increased: 11 people, 20.75%
  2. Blood Bilirubin Increased: 10 people, 18.87%
  3. Bleeding Disorders: 9 people, 16.98%
  4. Nausea (feeling of having an urge to vomit): 9 people, 16.98%
  5. Nausea And Vomiting: 9 people, 16.98%
  6. Drug-Induced Liver Injury (diseases of the liver that are caused by physician-prescribed medications): 9 people, 16.98%
  7. Gamma-Glutamyltransferase Increased: 8 people, 15.09%
  8. Fatigue (feeling of tiredness): 8 people, 15.09%
  9. Aspartate Aminotransferase Increased: 8 people, 15.09%
  10. Drowsiness: 7 people, 13.21%

Common conditions people have *:

  1. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 8 people, 15.09%
  2. Drug Exposure During Pregnancy: 3 people, 5.66%
  3. Febrile Convulsion (a convulsion associated with a significant rise in body temperature): 2 people, 3.77%
  4. Status Epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 2 people, 3.77%
  5. Peritumoural Oedema (swelling from excessive accumulation of watery fluid in cells in peritumoural): 2 people, 3.77%
  6. Encephalitis Viral (inflammation of the brain due to viral infection): 2 people, 3.77%
  7. Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 1 person, 1.89%
  8. Anaemia Postoperative: 1 person, 1.89%
  9. Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 1 person, 1.89%
  10. Brucellosis (a bacterial disease typically affecting cattle and humans caused esp. by the bacteria brucella abortus): 1 person, 1.89%

* Approximation only. Some reports may have incomplete information.

Do you take Valproic acid and have Jaundice - yellow skin?

Check whether Jaundice - yellow skin is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

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Common Valproic acid side effects:

Browse all side effects of Valproic acid:

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Jaundice - yellow skin treatments and more:

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Common drugs associated with Jaundice - yellow skin:

All the drugs that are associated with Jaundice - yellow skin:

Common conditions associated with Jaundice - yellow skin:

All the conditions that are associated with Jaundice - yellow skin:

How the study uses the data?

The study uses data from the FDA. It is based on valproic acid (the active ingredients of Valproic acid) and Valproic acid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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