Valproic acid and Rotator cuff syndrome - a phase IV clinical study of FDA data


Rotator cuff syndrome is found among people who take Valproic acid, especially for people who are male, 50-59 old.

The phase IV clinical study analyzes which people take Valproic acid and have Rotator cuff syndrome. It is created by eHealthMe based on reports of 30,749 people who have side effects when taking Valproic acid from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Oct, 01, 2022

30,749 people reported to have side effects when taking Valproic acid.
Among them, 6 people (0.02%) have Rotator cuff syndrome.

What is Valproic acid?

Valproic acid has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 31,091 Valproic acid users for its effectiveness, alternative drugs and more.

What is Rotator cuff syndrome?

Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder) is found to be associated with 1,532 drugs and 1,005 conditions by eHealthMe.

Number of Valproic acid and Rotator cuff syndrome reports submitted per year:

Could Valproic acid cause Rotator cuff syndrome?

Gender of people who have Rotator cuff syndrome when taking Valproic acid *:

  • female: 0.0 %
  • male: 100 %

Age of people who have Rotator cuff syndrome when taking Valproic acid *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 100 %
  • 60+: 0.0 %

Common drugs people take besides Valproic acid *:

  1. Allopurinol: 6 people, 100.00%
  2. Ambien: 6 people, 100.00%
  3. Lisinopril: 6 people, 100.00%
  4. Zoloft: 5 people, 83.33%
  5. Methylphenidate: 5 people, 83.33%
  6. Morphine Sulfate: 5 people, 83.33%
  7. Depakote: 5 people, 83.33%
  8. Ultram: 4 people, 66.67%
  9. Temazepam: 4 people, 66.67%
  10. Adalat Cc: 4 people, 66.67%

Common side effects people have besides Rotator cuff syndrome *:

  1. Fall: 6 people, 100.00%
  2. Sleep Walking (walking during sleep): 5 people, 83.33%
  3. Neck Pain: 5 people, 83.33%
  4. Compression Fracture (fracture due to pressure caused by injury): 5 people, 83.33%
  5. Pain In Extremity: 4 people, 66.67%
  6. Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 4 people, 66.67%
  7. Weakness: 1 person, 16.67%
  8. Drowsiness: 1 person, 16.67%
  9. Anaemia (lack of blood): 1 person, 16.67%
  10. Arthropod Bite: 1 person, 16.67%

Common conditions people have *:

  1. Depression: 6 people, 100.00%
  2. Back Injury: 4 people, 66.67%
  3. Weight Loss: 1 person, 16.67%
  4. Hyperlipidaemia (presence of excess lipids in the blood): 1 person, 16.67%
  5. Dyslipidaemia (abnormal amount of lipids): 1 person, 16.67%
  6. Erection Problems: 1 person, 16.67%
  7. Essential Hypertension (primary hypertension): 1 person, 16.67%
  8. Gout (uric acid crystals building up in the body): 1 person, 16.67%
  9. Gouty Arthritis (joint inflammation with crystal formation): 1 person, 16.67%
  10. Hyperuricaemia (level of uric acid in the blood that is abnormally high): 1 person, 16.67%

* Approximation only. Some reports may have incomplete information.

Do you take Valproic acid and have Rotator cuff syndrome?

Check whether Rotator cuff syndrome is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

How severe was Rotator cuff syndrome and when was it recovered:

Expand to all the drugs that have ingredients of valproic acid:

Alternative drugs to, pros and cons of Valproic acid:

Common Valproic acid side effects:

Browse all side effects of Valproic acid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Rotator cuff syndrome treatments and more:

COVID vaccines that are related to Rotator cuff syndrome:

Common drugs associated with Rotator cuff syndrome:

All the drugs that are associated with Rotator cuff syndrome:

Common conditions associated with Rotator cuff syndrome:

All the conditions that are associated with Rotator cuff syndrome:

How the study uses the data?

The study uses data from the FDA. It is based on valproic acid (the active ingredients of Valproic acid) and Valproic acid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe: