Valsartan and Raynaud's phenomenon - a phase IV clinical study of FDA data


Raynaud's phenomenon is found among people who take Valsartan, especially for people who are male, 50-59 old, have been taking the drug for < 1 month.

The phase IV clinical study analyzes which people take Valsartan and have Raynaud's phenomenon. It is created by eHealthMe based on reports of 53,808 people who have side effects when taking Valsartan from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 27, 2022

53,808 people reported to have side effects when taking Valsartan.
Among them, 27 people (0.05%) have Raynaud's phenomenon.

What is Valsartan?

Valsartan has active ingredients of valsartan. It is often used in high blood pressure. eHealthMe is studying from 54,609 Valsartan users for its effectiveness, alternative drugs and more.

What is Raynaud's phenomenon?

Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas) is found to be associated with 1,343 drugs and 876 conditions by eHealthMe.

Number of Valsartan and Raynaud's phenomenon reports submitted per year:

Could Valsartan cause Raynaud's phenomenon?

Time on Valsartan when people have Raynaud's phenomenon *:

  • < 1 month: 40 %
  • 1 - 6 months: 20 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 40 %
  • 10+ years: 0.0 %

Gender of people who have Raynaud's phenomenon when taking Valsartan *:

  • female: 29.63 %
  • male: 70.37 %

Age of people who have Raynaud's phenomenon when taking Valsartan *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 35.29 %
  • 50-59: 47.06 %
  • 60+: 17.65 %

Common drugs people take besides Valsartan *:

  1. Folic Acid: 4 people, 14.81%
  2. Hydrochlorothiazide: 4 people, 14.81%
  3. Allopurinol: 4 people, 14.81%
  4. Aspirin: 4 people, 14.81%
  5. Colchicum: 4 people, 14.81%
  6. Escitalopram: 4 people, 14.81%
  7. Fentanyl: 4 people, 14.81%
  8. Humira: 4 people, 14.81%
  9. Acetaminophen: 4 people, 14.81%
  10. Prednisolone: 4 people, 14.81%

Common side effects people have besides Raynaud's phenomenon *:

  1. Weight Decreased: 12 people, 44.44%
  2. Drug Ineffective: 12 people, 44.44%
  3. Breathing Difficulty: 11 people, 40.74%
  4. Joint Pain: 11 people, 40.74%
  5. Night Sweats (sweating in night): 8 people, 29.63%
  6. Lymph Follicular Hypertrophy (an increase in the size of the lymph node follicles): 8 people, 29.63%
  7. Microangiopathic Haemolytic Anaemia (anaemia due to inability of bone marrow to compensate the premature destruction of red blood cells): 7 people, 25.93%
  8. Renal Impairment (severely reduced kidney function): 7 people, 25.93%
  9. Thrombocytopenia (decrease of platelets in blood): 7 people, 25.93%
  10. Scleroderma Renal Crisis (malignant hypertension develops and causes acute renal failure was once a common cause of death): 7 people, 25.93%

Common conditions people have *:

  1. Depression: 11 people, 40.74%
  2. Ankylosing Spondylitis (type of arthritis affecting the spine): 7 people, 25.93%
  3. Psoriasis (immune-mediated disease that affects the skin): 7 people, 25.93%
  4. Joint Pain: 7 people, 25.93%
  5. Sleep Disorder: 4 people, 14.81%
  6. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 4 people, 14.81%
  7. Prostatomegaly (enlargement of the prostate): 4 people, 14.81%
  8. Pain: 4 people, 14.81%
  9. Blood Uric Acid Increased: 4 people, 14.81%
  10. Breast Cancer Stage Iv: 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

Do you take Valsartan and have Raynaud's phenomenon?

Check whether Raynaud's phenomenon is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Raynaud's phenomenon and when was it recovered:

Expand to all the drugs that have ingredients of valsartan:

Alternative drugs to, pros and cons of Valsartan:

Common Valsartan side effects:

Browse all side effects of Valsartan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Raynaud's phenomenon treatments and more:

COVID vaccines that are related to Raynaud's phenomenon:

Common drugs associated with Raynaud's phenomenon:

All the drugs that are associated with Raynaud's phenomenon:

Common conditions associated with Raynaud's phenomenon:

All the conditions that are associated with Raynaud's phenomenon:

How the study uses the data?

The study uses data from the FDA. It is based on valsartan (the active ingredients of Valsartan) and Valsartan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe: