Valtrex and Middle insomnia - a phase IV clinical study of FDA data
Summary:
Middle insomnia is found among people who take Valtrex, especially for people who are female, 60+ old, have been taking the drug for < 1 month.
The phase IV clinical study analyzes which people take Valtrex and have Middle insomnia. It is created by eHealthMe based on reports of 32,398 people who have side effects when taking Valtrex from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.
With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse drug outcomes and monitor effectiveness. Our original studies have been referenced on 600+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Most recently, phase IV clinial trails for COVID 19 vaccines have been added, check here.
32,398 people reported to have side effects when taking Valtrex.
Among them, 103 people (0.32%) have Middle insomnia.
What is Valtrex?
Valtrex has active ingredients of valacyclovir hydrochloride. It is often used in genital herpes. eHealthMe is studying from 34,253 Valtrex users for its effectiveness, alternative drugs and more.
What is Middle insomnia?
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night) is found to be associated with 1,360 drugs and 895 conditions by eHealthMe.
Number of Valtrex and Middle insomnia reports submitted per year:

Time on Valtrex when people have Middle insomnia *:
Gender of people who have Middle insomnia when taking Valtrex*:
Age of people who have Middle insomnia when taking Valtrex *:
Common drugs people take besides Valtrex *:
Common side effects people have besides Middle insomnia *:
Common conditions people have *:
* Approximation only. Some reports may have incomplete information.
Do you take Valtrex and have Middle insomnia?
Check whether Middle insomnia is associated with a drug or a conditionHow to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related studies
Alternative drugs to, pros and cons of Valtrex:
- Valtrex (34,253 reports)
Middle insomnia treatments and more:
- Middle insomnia (16,860 reports)
COVID vaccines that are related to Middle insomnia:
- Middle insomnia in Moderna COVID Vaccine
- Middle insomnia in Pfizer BioNTech Covid Vaccine
- Middle insomnia in Johnson and Johnson Covid Vaccine
How severe was Middle insomnia and when was it recovered:
Expand to all the drugs that have ingredients of valacyclovir hydrochloride:
Common drugs associated with Middle insomnia:
- Acetylsalicylic acid: 148 reports
- Advair diskus 100/50: 107 reports
- Advair hfa: 588 reports
- Advil: 111 reports
- Albuterol: 186 reports
- Alprazolam: 161 reports
- Alvesco: 334 reports
- Ambien: 381 reports
- Amlodipine: 255 reports
- Ampyra: 159 reports
- Aspirin: 770 reports
- Atenolol: 268 reports
- Ativan: 190 reports
- Atorvastatin calcium: 132 reports
- Atrovent: 143 reports
- Avonex: 110 reports
- Baclofen: 131 reports
- Belsomra: 164 reports
- Benadryl: 206 reports
- Breo ellipta: 202 reports
- Budesonide: 116 reports
- Calcium: 221 reports
- Carbamazepine: 106 reports
- Celebrex: 179 reports
- Celexa: 116 reports
- Cetirizine hydrochloride: 133 reports
- Chantix: 416 reports
- Claritin: 126 reports
- Clonazepam: 384 reports
- Crestor: 236 reports
- Cymbalta: 315 reports
- Diazepam: 121 reports
- Effexor: 206 reports
- Enbrel: 190 reports
- Fish oil: 240 reports
- Flomax: 131 reports
- Flonase: 150 reports
- Flovent: 140 reports
- Fluoxetine: 102 reports
- Forteo: 396 reports
- Fosamax: 122 reports
- Furosemide: 181 reports
- Gabapentin: 317 reports
- Hetlioz: 346 reports
- Humira: 345 reports
- Hydrochlorothiazide: 238 reports
- Ibu: 233 reports
- Ibuprofen: 254 reports
- Klonopin: 175 reports
- Lamictal: 106 reports
- Lamotrigine: 113 reports
- Lasix: 151 reports
- Letairis: 122 reports
- Levothyroxine sodium: 133 reports
- Lexapro: 171 reports
- Lipitor: 413 reports
- Lisinopril: 465 reports
- Lopurin: 117 reports
- Lorazepam: 239 reports
- Losartan: 143 reports
- Lunesta: 1,272 reports
- Lyrica: 520 reports
- Magnesium: 147 reports
- Melatonin: 106 reports
- Metformin: 442 reports
- Methotrexate: 367 reports
- Metoprolol tartrate: 106 reports
- Montelukast sodium: 109 reports
- Morphine: 109 reports
- Multivitamin: 166 reports
- Nasonex: 202 reports
- Neurontin: 166 reports
- Nexium: 278 reports
- Niaspan: 341 reports
- Nitroglycerin: 114 reports
- Norvasc: 139 reports
- Omeprazole: 346 reports
- Pantoprazole: 342 reports
- Paxil: 152 reports
- Plaquenil: 146 reports
- Plavix: 178 reports
- Prednisone: 997 reports
- Pregabalin: 159 reports
- Premarin: 110 reports
- Prevacid: 105 reports
- Prilosec: 180 reports
- Pristiq: 101 reports
- Pulmicort: 239 reports
- Rozerem: 411 reports
- Seroquel: 273 reports
- Sertraline: 207 reports
- Simcor: 106 reports
- Simvastatin: 314 reports
- Singulair: 1,043 reports
- Spiriva: 776 reports
- Spironolactone: 112 reports
- Strattera: 155 reports
- Symbicort: 817 reports
- Synthroid: 491 reports
- Tecfidera: 151 reports
- Tramadol: 177 reports
- Tylenol: 356 reports
- Tysabri: 109 reports
- Valtrex: 103 reports
- Ventolin: 711 reports
- Vitamin b12: 158 reports
- Vitamin c: 167 reports
- Vitamin d: 378 reports
- Vitamin d3: 106 reports
- Vitamins: 138 reports
- Wellbutrin: 248 reports
- Xanax: 319 reports
- Xeljanz: 205 reports
- Xolair: 1,434 reports
- Xyrem: 367 reports
- Zide: 239 reports
- Zoloft: 256 reports
- Zolpidem: 174 reports
- Zopiclone: 158 reports
- Zyrtec: 180 reports
All the drugs that are associated with Middle insomnia:
- Middle insomnia (1,360 drugs)
Common conditions associated with Middle insomnia:
- Acid reflux: 293 reports
- Add: 180 reports
- Adhd: 180 reports
- Antidepressant therapy: 634 reports
- Anxiety: 375 reports
- Anxiety and stress: 375 reports
- Anxiety, apprehension, feeling uptight, jitters, stress, stress and anxiety, tension: 353 reports
- Anxiolytic therapy: 375 reports
- Asthma: 2,086 reports
- Attention deficit disorder with hyperactivity (addh): 180 reports
- Attention deficit hyperactivity disorder: 180 reports
- Attention deficit/hyperactivity disorder: 144 reports
- Attention deficit hyperactivity disorder (adhd): 171 reports
- Bipolar disorder: 118 reports
- Blood cholesterol abnormal: 605 reports
- Blood cholesterol increased: 605 reports
- Blood pressure - high: 540 reports
- Blood triglycerides abnormal: 605 reports
- Blood triglycerides increased: 605 reports
- Breathing difficulty: 166 reports
- Cancer - ovaries: 144 reports
- Cannot sleep: 1,516 reports
- Can't sleep: 1,516 reports
- Cataplexy: 134 reports
- Childhood hyperkinesis: 171 reports
- Chronic asthma: 2,080 reports
- Chronic obstructive pulmonary disease: 120 reports
- Circadian rhythm sleep disorder: 171 reports
- Constipation: 102 reports
- Copd: 130 reports
- Depression: 635 reports
- Diabetes: 188 reports
- Diabetes mellitus: 189 reports
- Diabetes - type 2: 115 reports
- Difficulty in breathing: 154 reports
- Dm: 188 reports
- Dyssomnia: 1,532 reports
- Fibromyalgia: 149 reports
- Fibromyalgia syndrome: 149 reports
- Gastroesophageal reflux disease: 293 reports
- Gastro-oesophageal reflux disease: 293 reports
- Gastrooesophageal reflux disease: 293 reports
- Gerd: 293 reports
- Hbp: 540 reports
- Heartburn: 328 reports
- Heartburn - chronic: 293 reports
- High blood cholesterol: 605 reports
- High blood cholesterol and triglycerides: 605 reports
- High blood pressure: 540 reports
- High cholesterol: 605 reports
- Htn: 540 reports
- Hypercholesterolaemia: 613 reports
- Hypercholesterolemia: 605 reports
- Hyperlipidemia: 605 reports
- Hypertension: 529 reports
- Hypothyroid: 163 reports
- Hypothyroidism: 163 reports
- Insomnia: 1,516 reports
- Insomnia concerns: 1,516 reports
- Low thyroid: 156 reports
- Migraine: 126 reports
- Migraines: 126 reports
- Ms: 487 reports
- Multiple sclerosis: 487 reports
- Narcolepsy: 242 reports
- Osteoporosis: 462 reports
- Pain: 370 reports
- Pain management: 367 reports
- Pain relief: 367 reports
- Pain relief by acupuncture: 384 reports
- Parkinson's disease: 442 reports
- Psoriatic arthropathy: 104 reports
- Quit smoking: 371 reports
- Ra: 404 reports
- Regional enteritis: 119 reports
- Restless leg syndrome: 113 reports
- Rheumatoid arthritis: 404 reports
- Sleep aid: 1,516 reports
- Sleep disorder: 354 reports
- Sleep disorder due to a general medical condition: 366 reports
- Sleep disorder due to general medical condition, insomnia type: 366 reports
- Sleeping: 1,516 reports
- Sleeping difficulty: 1,516 reports
- Sleep issues: 1,532 reports
- Sleeplessness: 1,516 reports
- Smoking cessation therapy: 371 reports
- Stress: 375 reports
- Stress and anxiety: 375 reports
- Tobacco user: 371 reports
- Type 2 diabetes: 110 reports
- Wakefulness: 1,532 reports
- Wheezing: 114 reports
All the conditions that are associated with Middle insomnia:
- Middle insomnia (895 conditions)
How the study uses the data?
The study uses data from the FDA. It is based on valacyclovir hydrochloride (the active ingredients of Valtrex) and Valtrex (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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