Valtrex and Osteonecrosis of jaw - a phase IV clinical study of FDA data
Summary:
Osteonecrosis of jaw is found among people who take Valtrex, especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months.
The phase IV clinical study analyzes which people take Valtrex and have Osteonecrosis of jaw. It is created by eHealthMe based on reports of 32,398 people who have side effects when taking Valtrex from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.
With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse drug outcomes and monitor effectiveness. Our original studies have been referenced on 600+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Most recently, phase IV clinial trails for COVID 19 vaccines have been added, check here.
On May, 30, 2022
32,398 people reported to have side effects when taking Valtrex.
Among them, 309 people (0.95%) have Osteonecrosis of jaw.
What is Valtrex?
Valtrex has active ingredients of valacyclovir hydrochloride. It is often used in genital herpes. eHealthMe is studying from 34,253 Valtrex users for its effectiveness, alternative drugs and more.
What is Osteonecrosis of jaw?
Osteonecrosis of jaw (death of bone of jaw) is found to be associated with 1,650 drugs and 873 conditions by eHealthMe.
Number of Valtrex and Osteonecrosis of jaw reports submitted per year:
Time on Valtrex when people have Osteonecrosis of jaw *:
Gender of people who have Osteonecrosis of jaw when taking Valtrex*:
Age of people who have Osteonecrosis of jaw when taking Valtrex *:
Common drugs people take besides Valtrex *:
Common side effects people have besides Osteonecrosis of jaw *:
Common conditions people have *:
* Approximation only. Some reports may have incomplete information.
Do you take Valtrex and have Osteonecrosis of jaw?
Check whether Osteonecrosis of jaw is associated with a drug or a conditionHow to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related publications that referenced our studies
- Mathai, P. C., Andrade, N. N., Aggarwal, N., Nerurkar, S., & Kapoor, P. , "Low-dose methotrexate in rheumatoid arthritis: a potential risk factor for bisphosphonate-induced osteonecrosis of the jaw", Oral and maxillofacial surgery, 2018 Jan .
- Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .
Related studies
Alternative drugs to, pros and cons of Valtrex:
- Valtrex (34,253 reports)
Osteonecrosis of jaw treatments and more:
- Osteonecrosis of jaw (33,278 reports)
COVID vaccines that are related to Osteonecrosis of jaw:
- Osteonecrosis of jaw in Moderna COVID Vaccine
- Osteonecrosis of jaw in Pfizer BioNTech Covid Vaccine
- Osteonecrosis of jaw in Johnson and Johnson Covid Vaccine
How severe was Osteonecrosis of jaw and when was it recovered:
Expand to all the drugs that have ingredients of valacyclovir hydrochloride:
Common drugs associated with Osteonecrosis of jaw:
- Abraxane: 219 reports
- Accupril: 162 reports
- Acetaminophen: 764 reports
- Acetaminophen and hydrocodone bitartrate: 241 reports
- Acetylsalicylic acid: 132 reports
- Aciphex: 270 reports
- Actonel: 849 reports
- Actos: 269 reports
- Acyclovir: 445 reports
- Adriamycin pfs: 558 reports
- Advair diskus 100/50: 474 reports
- Advil: 203 reports
- Afinitor: 316 reports
- Albuterol: 698 reports
- Albuterol sulfate: 182 reports
- Aldactone: 199 reports
- Alendronate sodium: 963 reports
- Alendronic acid: 523 reports
- Aleve: 170 reports
- Alkeran: 309 reports
- Allegra: 400 reports
- Allopurinol: 602 reports
- Aloxi: 201 reports
- Alprazolam: 554 reports
- Altace: 246 reports
- Amaryl: 139 reports
- Ambien: 1,563 reports
- Amlodipine: 408 reports
- Amoxicillin: 1,158 reports
- Anastrozole: 218 reports
- Ancef: 144 reports
- Anzemet: 212 reports
- Aranesp: 783 reports
- Aredia: 4,459 reports
- Arimidex: 912 reports
- Aromasin: 831 reports
- Aspirin: 1,995 reports
- Atacand: 105 reports
- Atenolol: 803 reports
- Ativan: 1,208 reports
- Atrovent: 177 reports
- Augmentin: 828 reports
- Augmentin '125': 615 reports
- Avandia: 218 reports
- Avastin: 842 reports
- Avelox: 471 reports
- Avodart: 139 reports
- Azithromycin: 304 reports
- Baclofen: 160 reports
- Bactrim: 458 reports
- Benadryl: 690 reports
- Benicar: 149 reports
- Bextra: 264 reports
- Biaxin: 238 reports
- Bicalutamide: 113 reports
- Bisacodyl: 131 reports
- Boniva: 760 reports
- Bortezomib: 163 reports
- Calcium: 652 reports
- Capecitabine: 259 reports
- Carafate: 124 reports
- Carboplatin: 562 reports
- Cardizem: 252 reports
- Carvedilol: 152 reports
- Casodex: 527 reports
- Cefazolin: 162 reports
- Ceftin: 112 reports
- Celebrex: 1,263 reports
- Celexa: 551 reports
- Centrum: 290 reports
- Centrum silver: 197 reports
- Cephalexin: 578 reports
- Chantix: 161 reports
- Chlorhexidine gluconate: 713 reports
- Cimetidine: 136 reports
- Cipro: 448 reports
- Cisplatin: 178 reports
- Citalopram hydrobromide: 173 reports
- Clarinex: 119 reports
- Claritin: 292 reports
- Cleocin: 229 reports
- Cleocin hydrochloride: 107 reports
- Clonazepam: 307 reports
- Clonidine: 269 reports
- Clopidogrel: 104 reports
- Clopra: 336 reports
- Clotrimazole: 133 reports
- Colace: 690 reports
- Combivent: 248 reports
- Compazine: 103 reports
- Coreg: 415 reports
- Cortisone acetate: 119 reports
- Coumadin: 1,586 reports
- Cozaar: 266 reports
- Crestor: 350 reports
- Cyclophosphamide: 511 reports
- Cymbalta: 697 reports
- Cytoxan: 707 reports
- Decadron: 1,758 reports
- Demerol: 316 reports
- Depo-medrol: 120 reports
- Detrol: 206 reports
- Dexamethasone: 1,649 reports
- Diazepam: 306 reports
- Diflucan: 478 reports
- Digoxin: 363 reports
- Dilaudid: 809 reports
- Diovan: 448 reports
- Ditropan: 101 reports
- Docetaxel: 525 reports
- Doxil: 201 reports
- Doxycycline: 508 reports
- Dulcolax: 147 reports
- Duragesic: 695 reports
- Duragesic-100: 564 reports
- Dyazide: 181 reports
- Effexor: 887 reports
- Effexor xr: 208 reports
- Elavil: 457 reports
- Eligard: 108 reports
- Enalapril maleate: 153 reports
- Enbrel: 140 reports
- Erythromycin: 143 reports
- Everolimus: 125 reports
- Evista: 275 reports
- Exemestane: 304 reports
- Exidine: 907 reports
- Famotidine: 340 reports
- Famvir: 239 reports
- Faslodex: 1,130 reports
- Femara: 1,368 reports
- Fentanyl: 890 reports
- Fentanyl citrate: 147 reports
- Fish oil: 311 reports
- Flagyl: 565 reports
- Flexeril: 606 reports
- Flomax: 448 reports
- Flonase: 388 reports
- Flovent: 170 reports
- Fluconazole: 424 reports
- Fluorouracil: 361 reports
- Fluoxetine: 222 reports
- Folic acid: 704 reports
- Forteo: 168 reports
- Fosamax: 5,128 reports
- Fulvestrant: 195 reports
- Furosemide: 894 reports
- Gabapentin: 867 reports
- Gemcitabine: 192 reports
- Gemzar: 403 reports
- Gentamicin: 108 reports
- Glipizide: 237 reports
- Glucophage: 207 reports
- Glucovance: 114 reports
- Glyburide: 166 reports
- Guaifenesin: 105 reports
- Heparin: 434 reports
- Herceptin: 696 reports
- Humalog: 131 reports
- Humira: 163 reports
- Hydrochlorothiazide: 871 reports
- Hydrocodone bitartrate and acetaminophen: 158 reports
- Hydrocortisone: 249 reports
- Hydroxyzine: 179 reports
- Hytrin: 116 reports
- Hyzaar: 115 reports
- Ibandronate sodium: 125 reports
- Ibrance: 202 reports
- Ibu: 967 reports
- Ibuprofen: 973 reports
- Imodium: 204 reports
- Indomethacin: 112 reports
- Insulin: 125 reports
- Keflex: 569 reports
- Keppra: 108 reports
- Ketoconazole: 200 reports
- Klonopin: 315 reports
- Klor-con: 350 reports
- Kytril: 299 reports
- Lactulose: 240 reports
- Lanoxin: 176 reports
- Lansoprazole: 313 reports
- Lantus: 325 reports
- Lasix: 1,533 reports
- Leflunomide: 135 reports
- Letrozole: 384 reports
- Levaquin: 1,276 reports
- Levofloxacin: 131 reports
- Levothyroxine sodium: 354 reports
- Levoxyl: 181 reports
- Lexapro: 737 reports
- Lidocaine: 338 reports
- Lidoderm: 234 reports
- Lipitor: 1,203 reports
- Lisinopril: 1,311 reports
- Lomotil: 238 reports
- Lopurin: 612 reports
- Loratadine: 120 reports
- Loraz: 852 reports
- Lorazepam: 852 reports
- Lortab: 788 reports
- Losartan: 159 reports
- Lotensin: 119 reports
- Lotrel: 173 reports
- Lovastatin: 155 reports
- Lovaza: 149 reports
- Lovenox: 609 reports
- Lunesta: 215 reports
- Lupron: 512 reports
- Lyrica: 893 reports
- Macrobid: 126 reports
- Magnesium: 527 reports
- Magnesium oxide: 152 reports
- Marinol: 124 reports
- Meclizine: 184 reports
- Medrol: 265 reports
- Megace: 421 reports
- Megestrol acetate: 240 reports
- Meloxicam: 201 reports
- Melphalan: 123 reports
- Melphalan hydrochloride: 348 reports
- Metformin: 675 reports
- Metformin hydrochloride: 107 reports
- Methotrexate: 774 reports
- Methylprednisolone: 217 reports
- Metoclopramide: 333 reports
- Metoprolol succinate: 160 reports
- Metoprolol tartrate: 414 reports
- Metronidazole: 423 reports
- Miacalcin: 167 reports
- Milk of magnesia: 169 reports
- Miralax: 399 reports
- Mirapex: 106 reports
- Mirtazapine: 179 reports
- Mobic: 290 reports
- Morphine: 1,315 reports
- Morphine sulfate: 514 reports
- Motrin: 308 reports
- Ms contin: 594 reports
- Mucinex: 160 reports
- Multivitamin: 308 reports
- Naprosyn: 244 reports
- Naproxen: 337 reports
- Nasacort: 124 reports
- Nasonex: 223 reports
- Navelbine: 553 reports
- Neulasta: 290 reports
- Neupogen: 407 reports
- Neurontin: 1,431 reports
- Nexium: 1,198 reports
- Nifedipine: 142 reports
- Nitroglycerin: 352 reports
- Nolvadex: 172 reports
- Norco: 283 reports
- Norvasc: 768 reports
- Novolog: 172 reports
- Nystatin: 452 reports
- Omeprazole: 965 reports
- Ondansetron: 341 reports
- Oxycodone: 1,086 reports
- Oxycontin: 1,657 reports
- Paclitaxel: 428 reports
- Pamidronate disodium: 607 reports
- Pantoprazole: 461 reports
- Paracetamol: 240 reports
- Paroxetine: 194 reports
- Paxil: 710 reports
- Pepcid: 522 reports
- Percocet: 1,340 reports
- Peridex: 844 reports
- Periogard: 111 reports
- Phenergan: 561 reports
- Plaquenil: 190 reports
- Plavix: 609 reports
- Pravachol: 203 reports
- Prednisolone: 789 reports
- Prednisone: 2,487 reports
- Premarin: 529 reports
- Prempro: 203 reports
- Prevacid: 887 reports
- Prilosec: 1,364 reports
- Prinivil: 191 reports
- Prochlorperazine: 335 reports
- Profen: 1,000 reports
- Prolia: 3,126 reports
- Propofol: 113 reports
- Proscar: 179 reports
- Protonix: 1,407 reports
- Provera: 162 reports
- Provigil: 188 reports
- Prozac: 515 reports
- Quinine sulfate: 123 reports
- Ramipril: 252 reports
- Ranitidine: 290 reports
- Reclast: 271 reports
- Reglan: 700 reports
- Relafen: 146 reports
- Remeron: 238 reports
- Restoril: 382 reports
- Revlimid: 1,325 reports
- Risedronate sodium: 119 reports
- Ritalin: 143 reports
- Robaxin: 120 reports
- Rocephin: 295 reports
- Roxanol: 120 reports
- Roxicet: 143 reports
- Se: 150 reports
- Selenium: 150 reports
- Senna: 268 reports
- Septra: 126 reports
- Seroquel: 161 reports
- Sertraline: 277 reports
- Sertraline hydrochloride: 182 reports
- Simvastatin: 885 reports
- Singulair: 310 reports
- Skelaxin: 247 reports
- Solu-medrol: 194 reports
- Soma: 182 reports
- Spiriva: 368 reports
- Spironolactone: 204 reports
- Sunitinib malate: 218 reports
- Sutent: 373 reports
- Symbicort: 168 reports
- Synthroid: 1,126 reports
- Tagamet: 158 reports
- Tamoxifen citrate: 914 reports
- Tarceva: 110 reports
- Taxol: 816 reports
- Taxotere: 1,195 reports
- Temaz: 407 reports
- Temazepam: 398 reports
- Tenormin: 138 reports
- Tequin: 109 reports
- Thalomid: 147 reports
- Toprol-xl: 520 reports
- Toradol: 309 reports
- Tramadol: 441 reports
- Trazodone hydrochloride: 143 reports
- Triamcinolone: 124 reports
- Tricor: 123 reports
- Tykerb: 124 reports
- Tylenol: 969 reports
- Tylenol w/ codeine: 149 reports
- Ultracet: 139 reports
- Ultram: 279 reports
- Unasyn: 182 reports
- Valium: 391 reports
- Valtrex: 309 reports
- Vasotec: 198 reports
- Velcade: 788 reports
- Versed: 215 reports
- Viagra: 154 reports
- Vicodin: 1,156 reports
- Vinorelbine: 124 reports
- Vioxx: 622 reports
- Vitamin b12: 110 reports
- Vitamin d: 406 reports
- Vitamins: 1,083 reports
- Voltaren: 133 reports
- Vytorin: 148 reports
- Warfarin sodium: 510 reports
- Wellbutrin: 611 reports
- Xalatan: 122 reports
- Xanax: 991 reports
- Xeloda: 1,012 reports
- Xgeva: 4,066 reports
- Xtandi: 134 reports
- Zanaflex: 107 reports
- Zantac: 608 reports
- Zestril: 247 reports
- Zetia: 237 reports
- Zide: 870 reports
- Zithromax: 547 reports
- Zocor: 792 reports
- Zofran: 1,203 reports
- Zoladex: 419 reports
- Zoledronic: 2,179 reports
- Zoledronic acid: 2,075 reports
- Zoloft: 961 reports
- Zolpidem: 332 reports
- Zometa: 11,933 reports
- Zosyn: 162 reports
- Zovirax: 173 reports
- Zyprexa: 152 reports
- Zyrtec: 458 reports
- Zytiga: 180 reports
- Zyvox: 108 reports
All the drugs that are associated with Osteonecrosis of jaw:
- Osteonecrosis of jaw (1,650 drugs)
Common conditions associated with Osteonecrosis of jaw:
- Acid reflux: 308 reports
- Acupuncture and pain: 676 reports
- Adenocarcinoma of renal cells: 404 reports
- Adult hypothyroidism: 310 reports
- Agrypnia: 194 reports
- Anaemia: 165 reports
- Antidepressant therapy: 620 reports
- Anxiety: 328 reports
- Anxiety and stress: 328 reports
- Anxiety, apprehension, feeling uptight, jitters, stress, stress and anxiety, tension: 330 reports
- Apprehension: 328 reports
- Arthritis: 191 reports
- Arthritis - rheumatoid: 635 reports
- Asthma: 201 reports
- Blood cholesterol abnormal: 488 reports
- Blood cholesterol increased: 483 reports
- Blood pressure - high: 1,331 reports
- Blood pressure increased: 1,305 reports
- Blood triglycerides abnormal: 483 reports
- Blood triglycerides increased: 483 reports
- Bone density decreased: 191 reports
- Bone density loss: 192 reports
- Bone disorder: 287 reports
- Bone lesion: 200 reports
- Bone loss: 202 reports
- Bone pain: 115 reports
- Breast cancer: 2,472 reports
- Breast cancer metastatic: 1,482 reports
- Cancer - breast: 2,472 reports
- Cancer - prostate: 1,405 reports
- Cannot sleep: 194 reports
- Carcinoma - ductal: 2,472 reports
- Carcinoma - lobular: 2,472 reports
- Chronic asthma: 194 reports
- Chronic obstructive pulmonary disease: 103 reports
- Constipation: 224 reports
- Depression: 620 reports
- Depression aggravated: 620 reports
- Diabetes: 295 reports
- Diabetes mellitus: 292 reports
- Dm: 295 reports
- Dyslipidemia: 488 reports
- Gastroesophageal reflux disease: 306 reports
- Gastrooesophageal reflux disease: 306 reports
- Gerd: 308 reports
- Glucose test: 193 reports
- Hbp: 1,305 reports
- High blood cholesterol: 483 reports
- High blood cholesterol and triglycerides: 483 reports
- High blood pressure: 1,305 reports
- High cholesterol: 488 reports
- Hormone replacement therapy: 182 reports
- Hrt: 182 reports
- Htn: 1,305 reports
- Hypercalcaemia: 223 reports
- Hypercalcaemia of malignancy: 127 reports
- Hypercholesterolaemia: 483 reports
- Hypercholesterolemia: 488 reports
- Hyperlipidemia: 483 reports
- Hyperlipoproteinemia: 483 reports
- Hypertension: 1,305 reports
- Hypothyroid: 310 reports
- Hypothyroidism: 310 reports
- Insomnia: 194 reports
- Jitters: 328 reports
- Joint inflammation: 190 reports
- Ldl/hdl ratio increased: 483 reports
- Lipoprotein test: 488 reports
- Lower cholesterol: 413 reports
- Low thyroid: 305 reports
- Lung neoplasm malignant: 133 reports
- Malignant plasmacytoma: 3,153 reports
- Metastases to bone: 6,584 reports
- Metastatic renal cell carcinoma: 284 reports
- Multiple myeloma: 3,153 reports
- Muscle spasms: 115 reports
- Myeloma - multiple: 3,103 reports
- Myxedema: 310 reports
- Nausea: 139 reports
- Neoplasm malignant: 419 reports
- Osteopenia: 1,316 reports
- Osteoporosis: 7,018 reports
- Osteoporosis postmenopausal: 906 reports
- Osteoporosis post-menopausal: 927 reports
- Pain: 858 reports
- Pain management: 846 reports
- Plasma cell dyscrasia: 3,153 reports
- Plasma cell myeloma: 3,103 reports
- Plasmacytoma of bone: 3,153 reports
- Preventive health care: 568 reports
- Prostate cancer: 1,429 reports
- Prostate cancer metastatic: 629 reports
- Ra: 635 reports
- Renal cancer: 404 reports
- Renal cell carcinoma: 414 reports
- Rheumatoid arthritis: 662 reports
- Sleep disorder: 170 reports
- Sleep disorder due to general medical condition, insomnia type: 167 reports
- Sleep - too much: 170 reports
- Stool softener: 215 reports
- Stool softener needs: 215 reports
- Stress: 328 reports
- Stress and anxiety: 328 reports
- Tension: 328 reports
- Thin bones: 6,644 reports
- Thrombosis: 149 reports
- Thyroid: 114 reports
- Thyroid diseases: 128 reports
- Thyroid disorder: 128 reports
- Thyroid function test abnormal: 132 reports
- Under active thyroid: 305 reports
- Underactive thyroid: 310 reports
- Under active thyroids: 305 reports
- Wakefulness: 194 reports
All the conditions that are associated with Osteonecrosis of jaw:
- Osteonecrosis of jaw (873 conditions)
How the study uses the data?
The study uses data from the FDA. It is based on valacyclovir hydrochloride (the active ingredients of Valtrex) and Valtrex (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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