Vioxx and Dupuytren's contracture - a phase IV clinical study of FDA data
Dupuytren's contracture is found among people who take Vioxx, especially for people who are male, 60+ old, have been taking the drug for 1 - 2 years.
The phase IV clinical study analyzes which people take Vioxx and have Dupuytren's contracture. It is created by eHealthMe based on reports of 109,817 people who have side effects when taking Vioxx from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
109,817 people reported to have side effects when taking Vioxx.
Among them, 31 people (0.03%) have Dupuytren's contracture.
What is Vioxx?
Vioxx has active ingredients of rofecoxib. It is often used in arthritis. eHealthMe is studying from 109,647 Vioxx users for its effectiveness, alternative drugs and more.
What is Dupuytren's contracture?
Dupuytren's contracture (thickening of the fibrous tissue layer underneath the skin of the palm and fingers) is found to be associated with 445 drugs and 208 conditions by eHealthMe.
Number of Vioxx and Dupuytren's contracture reports submitted per year:
Time on Vioxx when people have Dupuytren's contracture *:
- < 1 month: 4.35 %
- 1 - 6 months: 4.35 %
- 6 - 12 months: 0.0 %
- 1 - 2 years: 60.87 %
- 2 - 5 years: 26.09 %
- 5 - 10 years: 4.35 %
- 10+ years: 0.0 %
Gender of people who have Dupuytren's contracture when taking Vioxx *:
- female: 22.58 %
- male: 77.42 %
Age of people who have Dupuytren's contracture when taking Vioxx *:
- 0-1: 0.0 %
- 2-9: 0.0 %
- 10-19: 0.0 %
- 20-29: 0.0 %
- 30-39: 0.0 %
- 40-49: 26.67 %
- 50-59: 33.33 %
- 60+: 40.0 %
Common drugs people take besides Vioxx *:
- Zantac: 8 people, 25.81%
- Vicodin: 8 people, 25.81%
- Celexa: 8 people, 25.81%
- Lipitor: 6 people, 19.35%
- Prevacid: 3 people, 9.68%
- Zetia: 2 people, 6.45%
- Sinemet: 2 people, 6.45%
- Effexor Xr: 2 people, 6.45%
- Prilosec: 2 people, 6.45%
- Propulsid: 2 people, 6.45%
Common side effects people have besides Dupuytren's contracture *:
- Depression: 20 people, 64.52%
- Fatigue (feeling of tiredness): 16 people, 51.61%
- Stress And Anxiety: 13 people, 41.94%
- Erection Problems: 13 people, 41.94%
- Back Pain: 13 people, 41.94%
- Chest Pain: 13 people, 41.94%
- Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 12 people, 38.71%
- Spinal Column Stenosis (narrowing of spinal column): 12 people, 38.71%
- High Blood Pressure: 12 people, 38.71%
- Weakness: 11 people, 35.48%
Common conditions people have *:
- Depression: 10 people, 32.26%
- Indigestion: 8 people, 25.81%
- Gastric Disorder (disease of stomach): 2 people, 6.45%
- Sleep Disorder: 1 person, 3.23%
- Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 3.23%
- Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 3.23%
- Psoriasis (immune-mediated disease that affects the skin): 1 person, 3.23%
- Hyperuricaemia (level of uric acid in the blood that is abnormally high): 1 person, 3.23%
- High Blood Pressure: 1 person, 3.23%
- Gastric Ulcer (stomach ulcer): 1 person, 3.23%
* Approximation only. Some reports may have incomplete information.
Do you take Vioxx and have Dupuytren's contracture?Check whether Dupuytren's contracture is associated with a drug or a condition
How to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
How severe was Dupuytren's contracture and when was it recovered:
Expand to all the drugs that have ingredients of rofecoxib:
Alternative drugs to, pros and cons of Vioxx:
- Vioxx (109,647 reports)
Common Vioxx side effects:
Browse all side effects of Vioxx:a b c d e f g h i j k l m n o p q r s t u v w x y z
Dupuytren's contracture treatments and more:
- Dupuytren's contracture (2,031 reports)
COVID vaccines that are related to Dupuytren's contracture:
- Dupuytren's contracture in Moderna COVID Vaccine
- Dupuytren's contracture in Pfizer BioNTech Covid Vaccine
- Dupuytren's contracture in Johnson and Johnson Covid Vaccine
Common drugs associated with Dupuytren's contracture:
- Xiaflex: 137 reports
All the drugs that are associated with Dupuytren's contracture:
- Dupuytren's contracture (445 drugs)
Common conditions associated with Dupuytren's contracture:
- Ra: 104 reports
All the conditions that are associated with Dupuytren's contracture:
- Dupuytren's contracture (208 conditions)
How the study uses the data?
The study uses data from the FDA. It is based on rofecoxib (the active ingredients of Vioxx) and Vioxx (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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