Vioxx and High blood pressure - a phase IV clinical study of FDA data
Summary:
High blood pressure is found among people who take Vioxx, especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years.
The phase IV clinical study analyzes which people take Vioxx and have High blood pressure. It is created by eHealthMe based on reports of 109,817 people who have side effects when taking Vioxx from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
109,817 people reported to have side effects when taking Vioxx.
Among them, 13,104 people (11.93%) have High blood pressure.
What is Vioxx?
Vioxx has active ingredients of rofecoxib. It is often used in arthritis. eHealthMe is studying from 109,849 Vioxx users for its effectiveness, alternative drugs and more.
What is High blood pressure?
High blood pressure is found to be associated with 4,838 drugs and 5,128 conditions by eHealthMe.
Number of Vioxx and High blood pressure reports submitted per year:

Time on Vioxx when people have High blood pressure *:
Gender of people who have High blood pressure when taking Vioxx*:
Age of people who have High blood pressure when taking Vioxx *:
Common drugs people take besides Vioxx *:
Common side effects people have besides High blood pressure *:
Common conditions people have *:
* Approximation only. Some reports may have incomplete information.
Do you take Vioxx and have High blood pressure?
Check whether High blood pressure is associated with a drug or a conditionHow to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related studies
How severe was High blood pressure and when was it recovered:
Expand to all the drugs that have ingredients of rofecoxib:
- High blood pressure and drugs with ingredients of rofecoxib (13,218 reports)
Alternative drugs to, pros and cons of Vioxx:
- Vioxx (109,849 reports)
Common Vioxx side effects:
- Heart attack: 33,541 reports
- Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 24,347 reports
- High blood pressure: 13,957 reports
- Chest pain: 11,792 reports
- Coronary heart disease (narrowing or blockage of the coronary arteries): 8,606 reports
- Depression: 7,964 reports
Browse all side effects of Vioxx:
a b c d e f g h i j k l m n o p q r s t u v w x y zHigh blood pressure treatments and more:
- High blood pressure (942,833 reports)
COVID vaccines that are related to High blood pressure:
- High blood pressure in Moderna COVID Vaccine
- High blood pressure in Pfizer BioNTech Covid Vaccine
- High blood pressure in Johnson and Johnson Covid Vaccine
Common drugs associated with High blood pressure:
- Prednisone: 26,668 reports
- Aspirin: 20,101 reports
- Methotrexate: 18,668 reports
- Amlodipine: 16,475 reports
- Lisinopril: 14,644 reports
- Metformin: 13,835 reports
- Humira: 13,142 reports
- Vioxx: 13,104 reports
- Synthroid: 11,736 reports
- Pantoprazole: 10,768 reports
All the drugs that are associated with High blood pressure:
- High blood pressure (4,838 drugs)
Common conditions associated with High blood pressure:
- Rheumatoid arthritis: 26,033 reports
- Multiple sclerosis: 14,882 reports
- Pain: 12,230 reports
- Osteoporosis: 11,512 reports
- Asthma: 11,127 reports
All the conditions that are associated with High blood pressure:
- High blood pressure (5,128 conditions)
How the study uses the data?
The study uses data from the FDA. It is based on rofecoxib (the active ingredients of Vioxx) and Vioxx (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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