Vitamin b12 and Dupuytren's contracture - a phase IV clinical study of FDA data


Dupuytren's contracture is found among people who take Vitamin b12, especially for people who are female, 60+ old.

The phase IV clinical study analyzes which people take Vitamin b12 and have Dupuytren's contracture. It is created by eHealthMe based on reports of 86,813 people who have side effects when taking Vitamin b12 from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse drug outcomes and monitor effectiveness. Our original studies have been referenced on 600+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Most recently, phase IV clinial trails for COVID 19 vaccines have been added, check here.

On Jun, 04, 2022

86,813 people reported to have side effects when taking Vitamin b12.
Among them, 12 people (0.01%) have Dupuytren's contracture.

What is Vitamin b12?

Vitamin b12 has active ingredients of cobalamin. It is often used in vitamin b12 deficiency. eHealthMe is studying from 88,452 Vitamin b12 users for its effectiveness, alternative drugs and more.

What is Dupuytren's contracture?

Dupuytren's contracture (thickening of the fibrous tissue layer underneath the skin of the palm and fingers) is found to be associated with 430 drugs and 190 conditions by eHealthMe.

Number of Vitamin b12 and Dupuytren's contracture reports submitted per year:

Could Vitamin b12 cause Dupuytren's contracture?

Gender of people who have Dupuytren's contracture when taking Vitamin b12 *:

  • female: 75 %
  • male: 25 %

Age of people who have Dupuytren's contracture when taking Vitamin b12 *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 9.09 %
  • 60+: 90.91 %

Common drugs people take besides Vitamin b12 *:

  1. Synthroid: 8 people, 66.67%
  2. Januvia: 5 people, 41.67%
  3. Rituxan: 4 people, 33.33%
  4. Cellcept: 4 people, 33.33%
  5. Metformin: 4 people, 33.33%
  6. Vitamin B6: 4 people, 33.33%
  7. Plaquenil: 4 people, 33.33%
  8. Tylenol: 4 people, 33.33%
  9. Hydroxyzine: 4 people, 33.33%
  10. Prevacid: 3 people, 25.00%

Common side effects people have besides Dupuytren's contracture *:

  1. Cough: 7 people, 58.33%
  2. Joint Pain: 7 people, 58.33%
  3. Joint Swelling: 7 people, 58.33%
  4. Drug Ineffective: 7 people, 58.33%
  5. Nausea (feeling of having an urge to vomit): 7 people, 58.33%
  6. Diarrhea: 6 people, 50.00%
  7. Fall: 5 people, 41.67%
  8. Abdominal Pain: 4 people, 33.33%
  9. Hypoaesthesia (reduced sense of touch or sensation): 4 people, 33.33%
  10. Immunodeficiency Disorders: 4 people, 33.33%

Common conditions people have *:

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 7 people, 58.33%
  2. Vasculitis (inflammation of a blood vessel or blood vessels): 4 people, 33.33%
  3. Myositis (inflammation of the muscles): 4 people, 33.33%
  4. Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 4 people, 33.33%
  5. Polymyositis (inflammatory muscle disease that causes weakness of the skeletal muscles): 4 people, 33.33%
  6. Mixed Connective Tissue Disease (an autoimmune disease, in which the body's defence system attacks itself): 4 people, 33.33%
  7. Depression: 3 people, 25.00%
  8. Insomnia (sleeplessness): 3 people, 25.00%
  9. Pain: 3 people, 25.00%
  10. Glaucoma (increased fluid pressure in the eye with vision loss): 2 people, 16.67%

* Approximation only. Some reports may have incomplete information.

Do you take Vitamin b12 and have Dupuytren's contracture?

Check whether Dupuytren's contracture is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Alternative drugs to, pros and cons of Vitamin b12:

Dupuytren's contracture treatments and more:

COVID vaccines that are related to Dupuytren's contracture:

How severe was Dupuytren's contracture and when was it recovered:

Expand to all the drugs that have ingredients of cobalamin:

Common drugs associated with Dupuytren's contracture:

All the drugs that are associated with Dupuytren's contracture:

All the conditions that are associated with Dupuytren's contracture:

How the study uses the data?

The study uses data from the FDA. It is based on cobalamin (the active ingredients of Vitamin b12) and Vitamin b12 (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe: