Vitamin b12 and Non-hodgkin's lymphoma - a phase IV clinical study of FDA data


We study 110,661 people who have side effects when taking Vitamin b12. Non-hodgkin's lymphoma is found, especially among people who are female, 60+ old, have been taking the drug for 1 - 6 months, also take Vitamin d3 and have Depression.

The phase IV clinical study analyzes which people take Vitamin b12 and have Non-hodgkin's lymphoma. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

What are phase IV trials?

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 24, 2023

110,661 people reported to have side effects when taking Vitamin b12.
Among them, 68 people (0.06%) have Non-hodgkin's lymphoma.

What is Vitamin b12?

Vitamin b12 has active ingredients of cobalamin. It is used in vitamin b12 deficiency. Currently, eHealthMe is studying from 112,603 Vitamin b12 users.

What is Non-hodgkin's lymphoma?

Non-hodgkin's lymphoma (malignant (cancer) cells form in the lymph system) is found to be associated with 1,750 drugs and 1,326 conditions by eHealthMe. Currently, we are studying 73,745 people who have Non-hodgkin's lymphoma.

Number of Vitamin b12 and Non-hodgkin's lymphoma reports submitted per year:

Could Vitamin b12 cause Non-hodgkin's lymphoma?

Time on Vitamin b12 when people have Non-hodgkin's lymphoma *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 66.67 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 33.33 %
  • 10+ years: 0.0 %

Gender of people who have Non-hodgkin's lymphoma when taking Vitamin b12 *:

  • female: 64.18 %
  • male: 35.82 %

Age of people who have Non-hodgkin's lymphoma when taking Vitamin b12 *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 2.22 %
  • 30-39: 0.0 %
  • 40-49: 4.44 %
  • 50-59: 26.67 %
  • 60+: 66.67 %

Common drugs people take besides Vitamin b12 *:

  1. Vitamin D3: 20 people, 29.41%
  2. Vitamin D: 14 people, 20.59%
  3. Synthroid: 13 people, 19.12%
  4. Calcium: 12 people, 17.65%
  5. Revlimid: 11 people, 16.18%
  6. Adderall: 10 people, 14.71%
  7. Advair Hfa: 9 people, 13.24%
  8. Tylenol: 9 people, 13.24%
  9. Rituxan: 8 people, 11.76%
  10. Crestor: 8 people, 11.76%

Common side effects people have besides Non-hodgkin's lymphoma *:

  1. Memory Loss: 10 people, 14.71%
  2. Fall: 9 people, 13.24%
  3. Malaise (a feeling of general discomfort or uneasiness): 9 people, 13.24%
  4. Confusional State: 8 people, 11.76%
  5. Neoplasm Malignant (cancer tumour): 8 people, 11.76%
  6. Central Nervous System Lesion (an abnormality in tissue of brain or spinal cord): 7 people, 10.29%
  7. Otitis (ear infection): 7 people, 10.29%
  8. Weight Decreased: 7 people, 10.29%
  9. Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 7 people, 10.29%
  10. Weakness: 6 people, 8.82%

Common conditions people have *:

  1. Depression: 9 people, 13.24%
  2. Pain: 8 people, 11.76%
  3. High Blood Pressure: 7 people, 10.29%
  4. Thyroid Diseases: 7 people, 10.29%
  5. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 10.29%
  6. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 10.29%
  7. Crohn's Disease (condition that causes inflammation of the gastrointestinal tract): 6 people, 8.82%
  8. Nausea (feeling of having an urge to vomit): 6 people, 8.82%
  9. Memory Loss: 5 people, 7.35%
  10. Cardiac Disorder: 5 people, 7.35%

* Approximation only. Some reports may have incomplete information.

Do you take Vitamin b12 and have Non-hodgkin's lymphoma?

Check whether Non-hodgkin's lymphoma is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

How severe was Non-hodgkin's lymphoma and when was it recovered:

Expand to all the drugs that have ingredients of cobalamin:

Alternative drugs to, pros and cons of Vitamin b12:

Browse all side effects of Vitamin b12:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Non-hodgkin's lymphoma treatments and more:

Common drugs associated with Non-hodgkin's lymphoma:

All the drugs that are associated with Non-hodgkin's lymphoma:

Common conditions associated with Non-hodgkin's lymphoma:

All the conditions that are associated with Non-hodgkin's lymphoma:

How the study uses the data?

The study uses data from the FDA. It is based on cobalamin (the active ingredients of Vitamin b12) and Vitamin b12 (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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