Vitamin d3 and Dupuytren's contracture - a phase IV clinical study of FDA data

• Vitamin d3 (71,383 reports)

• Abdominal discomfort: 1,537 reports
• Abdominal distension: 919 reports
• Abdominal pain: 1,073 reports
• Abdominal pain upper: 2,103 reports
• Abnormal behavior: 162 reports
• Abnormal dreams: 135 reports
• Acne (skin problems that cause pimples): 271 reports
• Acute kidney failure: 1,234 reports
• Acute respiratory failure: 170 reports
• Acute upper airway obstruction (blockage occurs in the upper airway): 140 reports
• Adverse drug reaction: 532 reports
• Adverse event: 495 reports
• Ageusia (loss of taste functions of the tongue): 228 reports
• Aggression: 113 reports
• Agitation (state of anxiety or nervous excitement): 458 reports
• Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 419 reports
• Alanine aminotransferase increased: 277 reports
• Anaemia (lack of blood): 1,049 reports
• Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 167 reports
• Anger: 106 reports
• Anhedonia (inability to experience pleasure from activities usually found enjoyable): 211 reports
• Ankle fracture: 183 reports
• Ankylosing spondylitis (type of arthritis affecting the spine): 109 reports
• Appetite - decreased (decreased appetite occurs when you have a reduced desire to eat): 1,672 reports
• Appetite - increased (increased appetite is when you want to eat much more often or in larger quantities than your body requires): 251 reports
• Arrhythmias (irregular heartbeat): 437 reports
• Arthritis (form of joint disorder that involves inflammation of one or more joints): 718 reports
• Arthropathy: 503 reports
• Aspartate aminotransferase increased: 222 reports
• Asthma: 583 reports
• Atrial fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 761 reports
• Back disorder: 194 reports
• Back injury: 119 reports
• Back pain: 2,186 reports
• Balance disorder: 1,290 reports
• Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills): 222 reports
• Bladder disorder: 131 reports
• Blindness: 160 reports
• Blood alkaline phosphatase increased: 129 reports
• Blood calcium decreased: 102 reports
• Blood creatinine increased: 459 reports
• Blood glucose decreased: 226 reports
• Blood glucose increased: 517 reports
• Blood iron decreased: 187 reports
• Blood magnesium decreased: 105 reports
• Blood potassium decreased: 335 reports
• Blood pressure fluctuation: 371 reports
• Blood pressure management: 238 reports
• Blood pressure systolic increased: 175 reports
• Body height decreased: 251 reports
• Body temperature increased: 253 reports
• Bone density decreased: 170 reports
• Bone pain: 471 reports
• Bradycardia (abnormally slow heart action): 135 reports
• Breast cancer: 204 reports
• Breathing difficulty: 3,950 reports
• Broken bone: 142 reports
• Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection): 104 reports
• Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 815 reports
• Burning sensation: 546 reports
• Cardiac arrest: 164 reports
• Cardiac failure: 179 reports
• Cardiac failure congestive: 458 reports
• Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling): 158 reports
• Cataract (clouding of the lens inside the eye): 527 reports
• Cellulitis (infection under the skin): 434 reports
• Central nervous system lesion (an abnormality in tissue of brain or spinal cord): 268 reports
• Cerebral haemorrhage (bleeding within the brain): 119 reports
• Chest pain: 1,552 reports
• Chills (felling of cold): 839 reports
• Chronic kidney disease: 1,809 reports
• Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe): 358 reports
• Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving): 334 reports
• Colitis (inflammation of colon): 294 reports
• Concussion (short loss of normal brain function in response to a head injury): 115 reports
• Condition: 694 reports
• Confusion: 176 reports
• Confusional state: 945 reports
• Consciousness - decreased: 137 reports
• Constipation: 2,075 reports
• Cough: 2,048 reports
• Coughing up blood: 222 reports
• C-reactive protein increased: 202 reports
• Crohn's disease (condition that causes inflammation of the gastrointestinal tract): 293 reports
• Crying: 159 reports
• Cyst (a closed sac): 191 reports
• Death: 2,496 reports
• Decreased interest: 153 reports
• Deep venous thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 252 reports
• Dehydration (dryness resulting from the removal of water): 992 reports
• Delirium (wild excitement): 105 reports
• Delusion (a false belief or opinion): 118 reports
• Dementia (madness): 190 reports
• Dental caries: 112 reports
• Depressed mood: 565 reports
• Depression: 1,993 reports
• Device dislocation: 103 reports
• Diabetes: 357 reports
• Diabetes mellitus inadequate control: 122 reports
• Diarrhea: 5,019 reports
• Diplopia (double vision): 171 reports
• Discomfort: 300 reports
• Disease progression: 372 reports
• Disease recurrence: 192 reports
• Disturbance in attention: 321 reports
• Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall): 253 reports
• Dizziness: 3,582 reports
• Drowsiness: 1,486 reports
• Drug dependence: 122 reports
• Drug effect decreased: 121 reports
• Drug hypersensitivity: 1,047 reports
• Drug ineffective: 4,079 reports
• Drug intolerance (drug sensitivity): 741 reports
• Dry eyes (lack of adequate tears): 432 reports
• Dry mouth: 928 reports
• Dry skin: 621 reports
• Dry throat: 108 reports
• Dyspnea exertional: 326 reports
• Dysstasia (difficulty in standing): 286 reports
• Ear pain: 353 reports
• Eating disorder: 128 reports
• Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 150 reports
• Emotional distress: 352 reports
• Erection problems: 113 reports
• Exostosis (formation of new bone on the surface of a bone): 136 reports
• Eye disorder: 230 reports
• Eye pain: 286 reports
• Eye pruritus (eye itching): 152 reports
• Eye swelling: 157 reports
• Faeces discolored: 124 reports
• Fainting (loss of consciousness and postural tone): 464 reports
• Fall: 3,609 reports
• Fatigue (feeling of tiredness): 7,498 reports
• Fear: 125 reports
• Febrile neutropenia (fever with reduced white blood cells): 199 reports
• Feeling cold: 138 reports
• Feeling hot: 287 reports
• Feeling jittery: 131 reports
• Femur fracture: 155 reports
• Fever: 1,582 reports
• Fibromyalgia (a long-term condition which causes pain all over the body): 295 reports
• Flatulence (flatus expelled through the anus): 426 reports
• Fluid overload (too much fluid in the blood): 116 reports
• Fluid retention (an abnormal accumulation of fluid in the blood): 409 reports
• Foot deformity (functional disability of foot): 129 reports
• Foot fracture: 202 reports
• Fungal infection: 200 reports
• Gait disturbance: 1,988 reports
• Gallstones (stone formation by bile component): 190 reports
• Gastric ulcer (stomach ulcer): 247 reports
• Gastritis (inflammation of stomach): 149 reports
• Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection): 205 reports
• Gastroesophageal reflux disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 949 reports
• Gastrointestinal disorder (functional problems of gastrointestinal tract): 584 reports
• Gastrointestinal haemorrhage (bleeding gastrointestinal tract): 436 reports
• General physical health deterioration (weak health status): 407 reports
• Glaucoma (increased fluid pressure in the eye with vision loss): 144 reports
• Glossodynia (a burning or painful sensation in the tongue): 211 reports
• Gout (uric acid crystals building up in the body): 197 reports
• Groin pain: 120 reports
• Haematochezia (passage of stools containing blood): 361 reports
• Haematocrit decreased: 232 reports
• Haematuria (presence of blood in urine): 147 reports
• Haemoglobin decreased: 977 reports
• Haemorrhage (bleeding): 439 reports
• Haemorrhoids (a swollen vein or group of veins in the region of the anus): 174 reports
• Hair color changes: 179 reports
• Hair disorder: 131 reports
• Hair loss: 1,749 reports
• Hallucinations (sensations that appear real but are created by your mind): 607 reports
• Hallucination, visual (seeing things that aren't there): 115 reports
• Headache (pain in head): 4,294 reports
• Head discomfort: 144 reports
• Head injury: 1,322 reports
• Hearing loss: 146 reports
• Heart attack: 554 reports
• Heart palpitations (feelings or sensations that your heart is pounding or racing): 737 reports
• Heart rate decreased: 321 reports
• Heart rate increased: 643 reports
• Heart rate irregular: 198 reports
• Hemiparesis (weakness on one side of the body): 128 reports
• Hepatic enzyme increased: 482 reports
• Hepatic steatosis (fatty liver disease): 128 reports
• Hereditary angioedema (recurrent episodes of severe swelling): 110 reports
• Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle): 207 reports
• Herpes zoster: 513 reports
• Hiatal hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 177 reports
• High blood cholesterol: 592 reports
• High blood pressure: 2,811 reports
• Hip fracture: 276 reports
• Hip joint replacement: 142 reports
• Hoarseness or changing voice: 474 reports
• Hospitalisation: 785 reports
• Hot flush (sudden feelings of heat): 454 reports
• Hypercalcaemia (elevated calcium (ca+) level in the blood): 160 reports
• Hyperhidrosis (abnormally increased sweating): 867 reports
• Hyperkalemia (damage to or disease of the kidney): 326 reports
• Hyperlipidaemia (presence of excess lipids in the blood): 130 reports
• Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary): 212 reports
• Hypersensitivity: 1,008 reports
• Hypoacusis (loss of hearing): 347 reports
• Hypoaesthesia (reduced sense of touch or sensation): 1,469 reports
• Hypocalcaemia (levels of calcium in blood serum are abnormally low): 104 reports
• Hypoglycemia (low blood sugar): 108 reports
• Hypokalemia (low potassium): 193 reports
• Hypokinesia (decreased bodily movement): 122 reports
• Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 231 reports
• Hypophagia (reduced food intake): 181 reports
• Hypotension (abnormally low blood pressure): 1,220 reports
• Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 240 reports
• Idiopathic pulmonary fibrosis (chronic lung disease): 130 reports
• Ill-defined disorder: 289 reports
• Immunodeficiency: 144 reports
• Impaired healing: 244 reports
• Impaired work ability: 130 reports
• Indigestion: 702 reports
• Infection: 945 reports
• Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus): 352 reports
• Inflammation: 306 reports
• Influenza like illness: 576 reports
• Infusion related reaction: 593 reports
• Initial insomnia (feeling of inadequate or poor-quality sleep): 114 reports
• Injection site bruising: 310 reports
• Injection site erythema (redness at injection site): 363 reports
• Injection site haemorrhage (bleeding from injection site): 178 reports
• Injection site pain: 643 reports
• Injection site pruritus (severe itching at injection site): 287 reports
• Injection site rash: 127 reports
• Injection site reaction: 287 reports
• Injury: 113 reports
• Insomnia (sleeplessness): 2,121 reports
• Interstitial lung disease: 181 reports
• Interstitial nephritis (inflammation of the kidney): 138 reports
• Intervertebral disc degeneration (spinal disc degeneration): 145 reports
• Intervertebral disc protrusion (spinal disc protrusion): 217 reports
• Intestinal obstruction: 318 reports
• Irritability: 260 reports
• Irritable bowel syndrome: 148 reports
• Itching: 2,083 reports
• Joint injury: 199 reports
• Joint pain: 3,205 reports
• Joint range of motion decreased (disease of joint movement): 129 reports
• Joint stiffness: 172 reports
• Joint swelling: 1,419 reports
• Kidney infection: 164 reports
• Kidney stones: 552 reports
• Knee joint replacement: 186 reports
• Lacrimation increased: 214 reports
• Laryngitis (inflammation of the larynx): 103 reports
• Leukopenia (less number of white blood cells in blood): 134 reports
• Limb discomfort (discomfort in leg): 336 reports
• Limb injury: 213 reports
• Lip swelling: 152 reports
• Liver disorder (liver diseases): 173 reports
• Localised infection (infection at the single location): 214 reports
• Loss of consciousness: 657 reports
• Lower limb fracture: 131 reports
• Lower respiratory tract infection: 259 reports
• Lung disorder (lung disease): 205 reports
• Lymphocyte count decreased: 211 reports
• Macular degeneration (painless eye condition that leads to the gradual loss of central vision): 578 reports
• Malaise (a feeling of general discomfort or uneasiness): 2,441 reports
• Malignant neoplasm progression (cancer tumour came back): 281 reports
• Memory loss: 1,872 reports
• Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 132 reports
• Micturition urgency (urgency to pass the urine): 174 reports
• Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night): 106 reports
• Migraine (headache): 776 reports
• Mobility decreased (ability to move is reduced): 1,142 reports
• Mood swings (an extreme or rapid change in mood): 200 reports
• Mouth ulcers: 122 reports
• Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness): 249 reports
• Movement - uncoordinated: 179 reports
• Multiple myeloma (cancer of the plasma cells): 231 reports
• Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 759 reports
• Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 882 reports
• Muscle aches (muscle pain): 991 reports
• Muscle spasms (muscle contraction): 1,584 reports
• Muscle spasticity (tight or stiff muscles and an inability to control those muscles): 299 reports
• Muscle tightness: 112 reports
• Muscle twitching: 138 reports
• Musculoskeletal chest pain (pain in chest muscle or nerve or bones): 137 reports
• Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves): 217 reports
• Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 490 reports
• Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 1,045 reports
• Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 413 reports
• Nasopharyngitis (inflammation of the nasopharynx): 2,287 reports
• Nausea (feeling of having an urge to vomit): 6,446 reports
• Nausea and vomiting: 3,243 reports
• Neck pain: 546 reports
• Neoplasm malignant (cancer tumour): 184 reports
• Nephrogenic anaemia (anaemia due to kidney disease): 320 reports
• Nephropathy (damage to or disease of a kidney): 105 reports
• Nerve injury: 134 reports
• Nervousness: 370 reports
• Neuralgia (pain in one or more nerves): 328 reports
• Neuropathy peripheral (surface nerve damage): 969 reports
• Neutrophil count decreased (less than normal number of neutrophil a type of blood cell): 256 reports
• Nightmares (unpleasant dreams): 172 reports
• Night sweats (sweating in night): 437 reports
• Nosebleed (bleeding from nose): 527 reports
• Ocular hyperaemia (an abnormally large amount of blood in eye): 182 reports
• Oedema (fluid collection in tissue): 337 reports
• Oedema peripheral (superficial swelling): 610 reports
• Oral herpes (viral infection of mouth): 208 reports
• Oral pain: 258 reports
• Oropharyngeal pain: 728 reports
• Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up): 102 reports
• Osteoarthritis (a joint disease caused by cartilage loss in a joint): 829 reports
• Osteopenia (a condition where bone mineral density is lower than normal): 265 reports
• Osteoporosis (bones weak and more likely to break): 576 reports
• Otitis (ear infection): 235 reports
• Overdose: 195 reports
• Oxygen saturation decreased: 358 reports
• Pain: 4,066 reports
• Pain in extremity: 2,489 reports
• Pain in jaw: 226 reports
• Pancreatitis (inflammation of pancreas): 152 reports
• Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 173 reports
• Panic disorder: 230 reports
• Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 1,645 reports
• Parkinson's disease: 230 reports
• Pemphigus (any of several acute or chronic skin diseases characterized by groups of itching blisters): 111 reports
• Peripheral swelling: 2,004 reports
• Photophobia (extreme sensitivity to light): 127 reports
• Photosensitivity reaction: 124 reports
• Pleural effusion (water on the lungs): 291 reports
• Pneumonia: 2,453 reports
• Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree): 208 reports
• Pollakiuria (abnormally frequent passage of relatively small quantities or urine): 366 reports
• Poor quality sleep: 164 reports
• Pre-existing condition improved: 298 reports
• Procedural pain: 145 reports
• Productive cough: 489 reports
• Prostatic specific antigen increased: 131 reports
• Psoriasis (immune-mediated disease that affects the skin): 486 reports
• Pulmonary embolism (blockage of the main artery of the lung): 431 reports
• Pulmonary hypertension (increase in blood pressure in the lung artery): 159 reports
• Pulmonary mass: 229 reports
• Rash erythematous (redness of the skin): 181 reports
• Rashes (redness): 3,300 reports
• Red blood cell count decreased: 418 reports
• Red blood cell sedimentation rate increased: 104 reports
• Relapsing-remitting multiple sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 108 reports
• Renal disorder (kidney disease): 340 reports
• Renal impairment (severely reduced kidney function): 629 reports
• Renal injury (kidney injury): 404 reports
• Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 260 reports
• Respiratory disorder (respiratory disease): 272 reports
• Respiratory tract congestion (blockage on respiratory system): 125 reports
• Respiratory tract infection: 146 reports
• Restless leg syndrome (a powerful urge to move your legs): 249 reports
• Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints): 1,103 reports
• Rheumatoid factor positive: 344 reports
• Rib fracture: 217 reports
• Rickets (softening of bones): 314 reports
• Scar: 143 reports
• Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve): 155 reports
• Seasonal allergy (allergic condition due to certain season): 190 reports
• Secretion discharge: 133 reports
• Seizures (abnormal excessive or synchronous neuronal activity in the brain): 896 reports
• Sensory disturbance (sense disturbance): 109 reports
• Sepsis (a severe blood infection that can lead to organ failure and death): 615 reports
• Septic shock (shock due to blood infection): 144 reports
• Sinus congestion (blockage of sinus): 147 reports
• Sinus disorder (disease of sinus): 287 reports
• Sinusitis (inflammation of sinus): 1,635 reports
• Skin blushing/flushing (a sudden reddening of the face, neck): 644 reports
• Skin burning sensation: 142 reports
• Skin cancer: 197 reports
• Skin discoloration: 357 reports
• Skin disorder (skin disease): 220 reports
• Skin exfoliation (removal of the oldest dead skin cells): 344 reports
• Skin infection: 101 reports
• Skin irritation: 103 reports
• Skin ulcer: 203 reports
• Sleep apnea syndrome: 518 reports
• Sleep disorder: 545 reports
• Small intestinal obstruction (blockage in small intestine): 108 reports
• Sneezing: 197 reports
• Speech disorder: 383 reports
• Speech impairment (adult) (inability to speak (adult)): 399 reports
• Spinal fracture (fracture in one of vertebrae): 176 reports
• Spinal pain (pain in spine): 108 reports
• Splenomegaly (enlargement of spleen): 194 reports
• Squamous cell carcinoma (a cancer of a kind of epithelial cell): 115 reports
• Staphylococcal infection (an infection with staphylococcus bacteria): 204 reports
• Stomatitis (inflammation of mucous membrane of mouth): 486 reports
• Stress and anxiety: 2,359 reports
• Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 648 reports
• Suicidal ideation: 447 reports
• Surgery: 453 reports
• Swallowing difficulty: 621 reports
• Swelling: 875 reports
• Swelling face: 261 reports
• Swollen tongue (swelling of tongue): 195 reports
• Synovitis (inflammation of the synovial membrane): 170 reports
• Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 669 reports
• Taste - impaired: 363 reports
• Temperature intolerance (inability to go in temperature): 184 reports
• Tenderness (pain or discomfort when an affected area is touched): 121 reports
• Tendonitis (a condition that causes pain and swelling of tendons): 132 reports
• The flu (the flu is caused by an influenza virus): 995 reports
• Therapeutic response decreased (less preventive response): 160 reports
• Therapeutic response unexpected: 490 reports
• Throat irritation: 240 reports
• Throat tightness: 133 reports
• Thrombocytopenia (decrease of platelets in blood): 1,051 reports
• Thrombosis (formation of a blood clot inside a blood vessel): 560 reports
• Thyroid diseases: 140 reports
• Tinnitus (a ringing in the ears): 283 reports
• Tooth abscess (pus formation in tooth): 337 reports
• Toothaches (tooth pain): 145 reports
• Tooth disorder (tooth disease): 254 reports
• Tooth fracture: 130 reports
• Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow)): 194 reports
• Tremor (trembling or shaking movements in one or more parts of your body): 1,142 reports
• Tumor: 135 reports
• Type 2 diabetes: 143 reports
• Ulcerative colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 201 reports
• Upper-airway cough syndrome: 117 reports
• Upper limb fracture: 202 reports
• Upper respiratory tract infection: 502 reports
• Urinary incontinence (inability to control the flow of urine and involuntary urination): 285 reports
• Urinary retention (the inability to completely or partially empty the bladder): 245 reports
• Urinary tract infection: 2,349 reports
• Urination - excessive at night: 137 reports
• Urination - painful: 246 reports
• Urticaria (rash of round, red welts on the skin that itch intensely): 740 reports
• Viral infection: 252 reports
• Viral upper respiratory tract infection: 111 reports
• Vision blurred: 780 reports
• Visual impairment: 771 reports
• Vitamin d decreased: 168 reports
• Weakness: 5,139 reports
• Weight decreased: 3,218 reports
• Weight increased: 2,402 reports
• Weight loss: 157 reports
• Wheezing (a high-pitched whistling sound made while you breath): 371 reports
• White blood cell count decreased: 1,263 reports
• White blood cell count increased: 419 reports
• Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance): 208 reports
• Wound: 268 reports
• Wrist fracture: 149 reports

• Dupuytren's contracture (2,031 reports)

All the drugs that are associated with Dupuytren's contracture:

• Dupuytren's contracture (445 drugs)

All the conditions that are associated with Dupuytren's contracture:

• Dupuytren's contracture (208 conditions)

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