Vitamin d3 and Eye discharge - a phase IV clinical study of FDA data


We study 112,976 people who have side effects when taking Vitamin d3. Eye discharge is found, especially among people who are female, 60+ old, also take Fish oil and have Dermatitis atopic.

The phase IV clinical study analyzes which people take Vitamin d3 and have Eye discharge. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 26, 2023

112,976 people reported to have side effects when taking Vitamin d3.
Among them, 97 people (0.09%) have Eye discharge.

What is Vitamin d3?

Vitamin d3 has active ingredients of ergocalciferol. It is used in mineral supplementation. Currently, eHealthMe is studying from 115,513 Vitamin d3 users.

What is Eye discharge?

Eye discharge is found to be associated with 1,265 drugs and 784 conditions by eHealthMe. Currently, we are studying 9,762 people who have Eye discharge.

Number of Vitamin d3 and Eye discharge reports submitted per year:

Could Vitamin d3 cause Eye discharge?

Gender of people who have Eye discharge when taking Vitamin d3 *:

  • female: 76.14 %
  • male: 23.86 %

Age of people who have Eye discharge when taking Vitamin d3 *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 2 %
  • 40-49: 8 %
  • 50-59: 24 %
  • 60+: 66 %

Common drugs people take besides Vitamin d3 *:

  1. Fish Oil: 20 people, 20.62%
  2. Vitamin B12: 17 people, 17.53%
  3. Vitamin C: 17 people, 17.53%
  4. Dupixent: 14 people, 14.43%
  5. Calcium: 11 people, 11.34%
  6. Zofran: 11 people, 11.34%
  7. Restasis: 11 people, 11.34%
  8. Coenzyme Q10: 10 people, 10.31%
  9. Oxervate: 10 people, 10.31%
  10. Zyrtec: 9 people, 9.28%

Common side effects people have besides Eye discharge *:

  1. Ocular Hyperaemia (an abnormally large amount of blood in eye): 20 people, 20.62%
  2. Eye Irritation: 20 people, 20.62%
  3. Diarrhea: 17 people, 17.53%
  4. Eye Pruritus (eye itching): 17 people, 17.53%
  5. Dry Eyes (lack of adequate tears): 14 people, 14.43%
  6. Nausea And Vomiting: 13 people, 13.40%
  7. Weight Decreased: 12 people, 12.37%
  8. Rashes (redness): 12 people, 12.37%
  9. Eye Swelling: 11 people, 11.34%
  10. Eye Pain: 10 people, 10.31%

Common conditions people have *:

  1. Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 13 people, 13.40%
  2. Neurotrophic Keratopathy (decreased corneal sensitivity and poor corneal healing): 9 people, 9.28%
  3. Nausea (feeling of having an urge to vomit): 8 people, 8.25%
  4. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 7.22%
  5. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 7.22%
  6. Multiple Myeloma (cancer of the plasma cells): 6 people, 6.19%
  7. High Blood Pressure: 6 people, 6.19%
  8. Asthma: 5 people, 5.15%
  9. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 5.15%
  10. Crohn's Disease (condition that causes inflammation of the gastrointestinal tract): 4 people, 4.12%

* Approximation only. Some reports may have incomplete information.

Do you take Vitamin d3 and have Eye discharge?

Check whether Eye discharge is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

Vitamin d3 side effects by duration, gender and age:

Eye discharge treatments and more:

Common drugs associated with Eye discharge:

All the drugs that are associated with Eye discharge:

Common conditions associated with Eye discharge:

All the conditions that are associated with Eye discharge:

How the study uses the data?

The study uses data from the FDA. It is based on ergocalciferol (the active ingredients of Vitamin d3) and Vitamin d3 (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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