Vitamin d3 and Nephrocalcinosis - a phase IV clinical study of FDA data


Nephrocalcinosis is found among people who take Vitamin d3, especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years.

The phase IV clinical study analyzes which people take Vitamin d3 and have Nephrocalcinosis. It is created by eHealthMe based on reports of 89,464 people who have side effects when taking Vitamin d3 from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Aug, 17, 2022

89,464 people reported to have side effects when taking Vitamin d3.
Among them, 16 people (0.02%) have Nephrocalcinosis.

What is Vitamin d3?

Vitamin d3 has active ingredients of ergocalciferol. It is often used in mineral supplementation. eHealthMe is studying from 71,383 Vitamin d3 users for its effectiveness, alternative drugs and more.

What is Nephrocalcinosis?

Nephrocalcinosis (a condition in which calcium levels in the kidneys are increased) is found to be associated with 499 drugs and 232 conditions by eHealthMe.

Number of Vitamin d3 and Nephrocalcinosis reports submitted per year:

Could Vitamin d3 cause Nephrocalcinosis?

Time on Vitamin d3 when people have Nephrocalcinosis *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 100 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Nephrocalcinosis when taking Vitamin d3 *:

  • female: 85.71 %
  • male: 14.29 %

Age of people who have Nephrocalcinosis when taking Vitamin d3 *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 8.33 %
  • 20-29: 25.0 %
  • 30-39: 0.0 %
  • 40-49: 33.33 %
  • 50-59: 0.0 %
  • 60+: 33.33 %

Common drugs people take besides Vitamin d3 *:

  1. Miralax: 4 people, 25.00%
  2. Acetylsalicylic Acid: 3 people, 18.75%
  3. Calcium: 3 people, 18.75%
  4. Ibrance: 3 people, 18.75%
  5. Morphine: 2 people, 12.50%
  6. Macrodantin: 2 people, 12.50%
  7. Vytorin: 2 people, 12.50%
  8. Valtrex: 2 people, 12.50%
  9. Synthroid: 2 people, 12.50%
  10. Cipro: 2 people, 12.50%

Common side effects people have besides Nephrocalcinosis *:

  1. Fatigue (feeling of tiredness): 4 people, 25.00%
  2. Pain: 4 people, 25.00%
  3. Anaemia (lack of blood): 3 people, 18.75%
  4. Hypocalcaemia (levels of calcium in blood serum are abnormally low): 3 people, 18.75%
  5. Weakness: 3 people, 18.75%
  6. Joint Pain: 3 people, 18.75%
  7. Weight Decreased: 2 people, 12.50%
  8. Haemorrhage (bleeding): 2 people, 12.50%
  9. Gallstones (stone formation by bile component): 2 people, 12.50%
  10. Gastric Haemorrhage (bleeding stomach): 2 people, 12.50%

Common conditions people have *:

  1. Hypoparathyroidism (inadequate secretion of parathyroid hormone resulting in abnormally low levels of calcium in the blood): 4 people, 25.00%
  2. Stress And Anxiety: 3 people, 18.75%
  3. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 18.75%
  4. Lung Disorder (lung disease): 2 people, 12.50%
  5. Breast Cancer: 2 people, 12.50%
  6. High Blood Cholesterol: 2 people, 12.50%
  7. Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection): 2 people, 12.50%
  8. Rickets (softening of bones): 2 people, 12.50%
  9. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 12.50%
  10. Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 2 people, 12.50%

* Approximation only. Some reports may have incomplete information.

Do you take Vitamin d3 and have Nephrocalcinosis?

Check whether Nephrocalcinosis is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

How severe was Nephrocalcinosis and when was it recovered:

Expand to all the drugs that have ingredients of ergocalciferol:

Alternative drugs to, pros and cons of Vitamin d3:

Common Vitamin d3 side effects:

Browse all side effects of Vitamin d3:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Nephrocalcinosis treatments and more:

COVID vaccines that are related to Nephrocalcinosis:

Common drugs associated with Nephrocalcinosis:

All the drugs that are associated with Nephrocalcinosis:

Common conditions associated with Nephrocalcinosis:

All the conditions that are associated with Nephrocalcinosis:

How the study uses the data?

The study uses data from the FDA. It is based on ergocalciferol (the active ingredients of Vitamin d3) and Vitamin d3 (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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