Voriconazole and Cheilitis - a phase IV clinical study of FDA data

• Voriconazole (17,764 reports)

• Abdominal pain: 251 reports
• Actinic keratosis (skin disease due to sun exposure): 315 reports
• Acute graft versus host disease in skin (acute complication on skin following an allogeneic tissue/blood transplant): 118 reports
• Acute kidney failure: 333 reports
• Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 179 reports
• Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 603 reports
• Alanine aminotransferase increased: 176 reports
• Anaemia (lack of blood): 418 reports
• Appetite - decreased (decreased appetite occurs when you have a reduced desire to eat): 263 reports
• Ards (acute respiratory distress syndrome) (sudden failure of the respiratory (breathing) system): 205 reports
• Arrhythmias (irregular heartbeat): 191 reports
• Aspartate aminotransferase increased: 173 reports
• Atrial fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 198 reports
• Back pain: 123 reports
• Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills): 126 reports
• Blood alkaline phosphatase increased: 141 reports
• Blood bilirubin increased: 144 reports
• Blood creatinine increased: 190 reports
• Bone marrow failure: 107 reports
• Breathing difficulty: 467 reports
• Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi): 792 reports
• Cardiac arrest: 170 reports
• Cardiac failure: 133 reports
• Cellulitis (infection under the skin): 158 reports
• Cerebral aspergillosis (pus collection with swelling in brain): 223 reports
• Cerebral haemorrhage (bleeding within the brain): 132 reports
• Chest pain: 160 reports
• Cholestasis (a condition where bile cannot flow from the liver to the duodenum): 162 reports
• Confusional state: 308 reports
• Constipation: 207 reports
• Cough: 366 reports
• Coughing up blood: 142 reports
• C-reactive protein increased: 146 reports
• Cytomegalovirus infection: 165 reports
• Death: 638 reports
• Dehydration (dryness resulting from the removal of water): 186 reports
• Delirium (wild excitement): 144 reports
• Depression: 117 reports
• Diarrhea: 570 reports
• Disease progression: 251 reports
• Disseminated intravascular coagulation (systemic activation of blood coagulation): 126 reports
• Dizziness: 206 reports
• Drowsiness: 131 reports
• Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications): 169 reports
• Drug ineffective: 2,635 reports
• Drug intolerance (drug sensitivity): 130 reports
• Drug level below therapeutic: 165 reports
• Drug level decreased: 122 reports
• Drug level increased: 394 reports
• Drug resistance (reduction in effectiveness of a drug): 491 reports
• Electrocardiogram qt prolonged: 199 reports
• Encephalopathy (functioning of the brain is affected by some agent or condition): 148 reports
• Endophthalmitis (inflammation of the internal coats of the eye): 155 reports
• Eye pain: 119 reports
• Fall: 153 reports
• Fatigue (feeling of tiredness): 386 reports
• Febrile neutropenia (fever with reduced white blood cells): 600 reports
• Fever: 1,022 reports
• Fungal infection: 413 reports
• Gait disturbance: 143 reports
• General physical health deterioration (weak health status): 154 reports
• Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 223 reports
• Haemoglobin decreased: 180 reports
• Hallucinations (sensations that appear real but are created by your mind): 308 reports
• Hallucination, visual (seeing things that aren't there): 230 reports
• Headache (pain in head): 340 reports
• Hepatic enzyme increased: 112 reports
• Hepatotoxicity (chemical-driven liver damage): 378 reports
• High blood pressure: 215 reports
• Hyperkalemia (damage to or disease of the kidney): 161 reports
• Hypoaesthesia (reduced sense of touch or sensation): 122 reports
• Hypokalemia (low potassium): 309 reports
• Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood): 130 reports
• Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 159 reports
• Hypotension (abnormally low blood pressure): 476 reports
• Infection: 276 reports
• Insomnia (sleeplessness): 133 reports
• Joint pain: 172 reports
• Leukopenia (less number of white blood cells in blood): 146 reports
• Lung disorder (lung disease): 137 reports
• Lung infection: 174 reports
• Malaise (a feeling of general discomfort or uneasiness): 143 reports
• Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 148 reports
• Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 131 reports
• Mucormycosis (a rare infection caused by organisms that belong to a group of fungi called mucoromycotina): 311 reports
• Multi-organ failure (multisystem organ failure): 157 reports
• Muscle aches (muscle pain): 109 reports
• Nausea (feeling of having an urge to vomit): 523 reports
• Nausea and vomiting: 418 reports
• Nephropathy toxic (damage to kidney due to toxins): 124 reports
• Nervous system disorder (a general class of medical conditions affecting the nervous system): 142 reports
• Neuropathy peripheral (surface nerve damage): 186 reports
• Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system): 206 reports
• Neutrophil count decreased (less than normal number of neutrophil a type of blood cell): 173 reports
• Oedema peripheral (superficial swelling): 128 reports
• Pain: 193 reports
• Pain in extremity: 135 reports
• Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 415 reports
• Pathogen resistance: 197 reports
• Periostitis (inflammation of the periosteum, a layer of connective tissue that surrounds bone): 209 reports
• Photodermatosis (skin disease that is caused by exposure to sunlight): 140 reports
• Photosensitivity reaction: 487 reports
• Pleural effusion (water on the lungs): 262 reports
• Pneumonia: 1,023 reports
• Pneumonia fungal: 111 reports
• Productive cough: 136 reports
• Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa): 123 reports
• Rashes (redness): 491 reports
• Renal failure acute (rapid kidney dysfunction): 202 reports
• Renal impairment (severely reduced kidney function): 209 reports
• Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 599 reports
• Respiratory distress (difficulty in breathing): 155 reports
• Scedosporium infection (a filamentous fungus which occasionally causes infections in humans): 138 reports
• Sepsis (a severe blood infection that can lead to organ failure and death): 530 reports
• Septic shock (shock due to blood infection): 522 reports
• Speech impairment (adult) (inability to speak (adult)): 110 reports
• Squamous cell carcinoma (a cancer of a kind of epithelial cell): 178 reports
• Squamous cell carcinoma of skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin): 362 reports
• Staphylococcal infection (an infection with staphylococcus bacteria): 164 reports
• Swallowing difficulty: 142 reports
• Systemic mycosis (fungal infections of the body): 143 reports
• The flu (the flu is caused by an influenza virus): 110 reports
• Thrombocytopenia (decrease of platelets in blood): 672 reports
• Transaminases increased: 147 reports
• Tremor (trembling or shaking movements in one or more parts of your body): 129 reports
• Uveitis (inflammation of the uvea): 109 reports
• Venoocclusive liver disease (small veins in the liver are obstructed): 119 reports
• Vision blurred: 155 reports
• Visual acuity reduced (reduced clearness of vision): 145 reports
• Visual impairment: 251 reports
• Weakness: 391 reports
• Weight decreased: 188 reports
• White blood cell count decreased: 197 reports

• Cheilitis (6,304 reports)

• Abreva: 153 reports
• Accutane: 732 reports
• Aspirin: 183 reports
• Augmentin: 105 reports
• Bactrim: 134 reports
• Enbrel: 103 reports
• Fosamax: 139 reports
• Humira: 168 reports
• Ibu: 114 reports
• Ibuprofen: 121 reports
• Lamictal: 176 reports
• Lisinopril: 112 reports
• Methotrexate: 246 reports
• Omeprazole: 138 reports
• Prednisone: 234 reports

All the drugs that are associated with Cheilitis:

• Cheilitis (1,288 drugs)

• Acne: 439 reports
• Antidepressant therapy: 156 reports
• Asthma: 126 reports
• Blood pressure increased: 224 reports
• Depression: 159 reports
• High blood cholesterol: 103 reports
• High blood pressure: 224 reports
• Hypertension: 241 reports
• Osteoporosis: 141 reports
• Pain: 140 reports
• Rheumatoid arthritis: 266 reports

All the conditions that are associated with Cheilitis:

• Cheilitis (854 conditions)

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