Xarelto and Trousseau's syndrome - a phase IV clinical study of FDA data


Trousseau's syndrome is found among people who take Xarelto, especially for people who are male, 60+ old, have been taking the drug for < 1 month.

The phase IV clinical study analyzes which people take Xarelto and have Trousseau's syndrome. It is created by eHealthMe based on reports of 195,181 people who have side effects when taking Xarelto from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Feb, 06, 2023

195,181 people reported to have side effects when taking Xarelto.
Among them, 9 people (0.0%) have Trousseau's syndrome.

What is Xarelto?

Xarelto has active ingredients of rivaroxaban. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 197,081 Xarelto users for its effectiveness, alternative drugs and more.

What is Trousseau's syndrome?

Trousseau's syndrome (the trousseau sign of malignancy is a medical sign found in certain cancers that is associated with venous thrombosis and hypercoagulability) is found to be associated with 149 drugs and 81 conditions by eHealthMe.

Number of Xarelto and Trousseau's syndrome reports submitted per year:

Could Xarelto cause Trousseau's syndrome?

Time on Xarelto when people have Trousseau's syndrome *:

  • < 1 month: 75 %
  • 1 - 6 months: 25 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Trousseau's syndrome when taking Xarelto *:

  • female: 50 %
  • male: 50 %

Age of people who have Trousseau's syndrome when taking Xarelto *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 0.0 %
  • 60+: 100 %

Common drugs people take besides Xarelto *:

  1. Amlodipine: 2 people, 22.22%
  2. Zometa: 1 person, 11.11%
  3. Valium: 1 person, 11.11%
  4. Micardis: 1 person, 11.11%
  5. Lasix: 1 person, 11.11%
  6. Gemcitabine: 1 person, 11.11%
  7. Emend: 1 person, 11.11%
  8. Decadron: 1 person, 11.11%
  9. Aloxi: 1 person, 11.11%

Common side effects people have besides Trousseau's syndrome *:

  1. Drug Ineffective: 3 people, 33.33%
  2. Cerebral Infarction (less blood supply to brain resulting tissue damage): 3 people, 33.33%
  3. Tumor Associated Fever: 1 person, 11.11%
  4. Pulmonary Embolism (blockage of the main artery of the lung): 1 person, 11.11%
  5. Lung Neoplasm Malignant (cancer tumour of lung): 1 person, 11.11%
  6. Iiird Nerve Paralysis (totally closed eyelid and a down and out deviation of the eye): 1 person, 11.11%
  7. Hepatic Function Abnormal: 1 person, 11.11%
  8. Haemorrhagic Infarction (stroke caused by the rupture of a blood vessel in the brain): 1 person, 11.11%
  9. Death: 1 person, 11.11%
  10. Cholecystitis (infection of gallbladder): 1 person, 11.11%

Common conditions people have *:

  1. Pulmonary Embolism (blockage of the main artery of the lung): 4 people, 44.44%
  2. Venous Thrombosis Limb (blood clot that forms in a vein in the limb): 1 person, 11.11%
  3. Urination - Excessive Volume: 1 person, 11.11%
  4. Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 1 person, 11.11%
  5. Kidney Infection (Pyelonephritis): 1 person, 11.11%
  6. Hypercalcaemia (elevated calcium (ca+) level in the blood): 1 person, 11.11%
  7. High Blood Pressure: 1 person, 11.11%
  8. Embolic Stroke (stroke due to obstruction due to an embolus): 1 person, 11.11%
  9. Embolic Cerebral Infarction (brain stroke due to obstruction of an artery): 1 person, 11.11%
  10. Constipation: 1 person, 11.11%

* Approximation only. Some reports may have incomplete information.

Do you take Xarelto and have Trousseau's syndrome?

Check whether Trousseau's syndrome is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Trousseau's syndrome and when was it recovered:

Expand to all the drugs that have ingredients of rivaroxaban:

Alternative drugs to, pros and cons of Xarelto:

Common Xarelto side effects:

Browse all side effects of Xarelto:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Trousseau's syndrome treatments and more:

COVID vaccines that are related to Trousseau's syndrome:

All the drugs that are associated with Trousseau's syndrome:

All the conditions that are associated with Trousseau's syndrome:

How the study uses the data?

The study uses data from the FDA. It is based on rivaroxaban (the active ingredients of Xarelto) and Xarelto (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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