Xeljanz and Nail ridging - a phase IV clinical study of FDA data
Summary:
Nail ridging is found among people who take Xeljanz, especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months.
The phase IV clinical study analyzes which people take Xeljanz and have Nail ridging. It is created by eHealthMe based on reports of 192,294 people who have side effects when taking Xeljanz from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
192,294 people reported to have side effects when taking Xeljanz.
Among them, 15 people (0.01%) have Nail ridging.
What is Xeljanz?
Xeljanz has active ingredients of tofacitinib citrate. It is often used in rheumatoid arthritis. eHealthMe is studying from 192,437 Xeljanz users for its effectiveness, alternative drugs and more.
What is Nail ridging?
Nail ridging (nail has raised ridges and is thin and curved inward) is found to be associated with 422 drugs and 280 conditions by eHealthMe.
Number of Xeljanz and Nail ridging reports submitted per year:

Time on Xeljanz when people have Nail ridging *:
- < 1 month: 0.0 %
- 1 - 6 months: 50 %
- 6 - 12 months: 50 %
- 1 - 2 years: 0.0 %
- 2 - 5 years: 0.0 %
- 5 - 10 years: 0.0 %
- 10+ years: 0.0 %
Gender of people who have Nail ridging when taking Xeljanz *:
- female: 80 %
- male: 20 %
Age of people who have Nail ridging when taking Xeljanz *:
- 0-1: 0.0 %
- 2-9: 0.0 %
- 10-19: 0.0 %
- 20-29: 0.0 %
- 30-39: 0.0 %
- 40-49: 0.0 %
- 50-59: 50 %
- 60+: 50 %
Common drugs people take besides Xeljanz *:
- Taltz: 1 person, 6.67%
- Sudafed 12 Hour: 1 person, 6.67%
- Prilosec: 1 person, 6.67%
- Otrexup: 1 person, 6.67%
- Otezla: 1 person, 6.67%
- Losartan: 1 person, 6.67%
- Edarbi: 1 person, 6.67%
- Celecoxib: 1 person, 6.67%
- Celebrex: 1 person, 6.67%
- Biotin: 1 person, 6.67%
Common side effects people have besides Nail ridging *:
- Musculoskeletal Stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 3 people, 20.00%
- Nail Disorder (disease of nail): 2 people, 13.33%
- Nail Pitting (small dents on the surface of your nails): 2 people, 13.33%
- Malaise (a feeling of general discomfort or uneasiness): 1 person, 6.67%
- High Blood Pressure: 1 person, 6.67%
- Hepatic Pain (pain in liver): 1 person, 6.67%
- Hepatic Enzyme Increased: 1 person, 6.67%
- Headache (pain in head): 1 person, 6.67%
- Gingival Disorder (gum disease): 1 person, 6.67%
- Gastric Disorder (disease of stomach): 1 person, 6.67%
Common conditions people have *:
- Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 3 people, 20.00%
- Psoriasis (immune-mediated disease that affects the skin): 3 people, 20.00%
- Joint Pain: 1 person, 6.67%
- Arthropathy: 1 person, 6.67%
- Arthritis (form of joint disorder that involves inflammation of one or more joints): 1 person, 6.67%
* Approximation only. Some reports may have incomplete information.
Do you take Xeljanz and have Nail ridging?
Check whether Nail ridging is associated with a drug or a conditionHow to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related studies
How severe was Nail ridging and when was it recovered:
Expand to all the drugs that have ingredients of tofacitinib citrate:
Alternative drugs to, pros and cons of Xeljanz:
- Xeljanz (192,437 reports)
Common Xeljanz side effects:
- Drug ineffective: 48,562 reports
- Pain: 26,984 reports
- Joint pain: 21,086 reports
- Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints): 20,971 reports
- Fatigue (feeling of tiredness): 16,775 reports
- Joint swelling: 15,442 reports
- Headache (pain in head): 13,556 reports
- Rashes (redness): 12,562 reports
- Malaise (a feeling of general discomfort or uneasiness): 11,656 reports
Browse all side effects of Xeljanz:
a b c d e f g h i j k l m n o p q r s t u v w x y zNail ridging treatments and more:
- Nail ridging (424 reports)
COVID vaccines that are related to Nail ridging:
- Nail ridging in Moderna COVID Vaccine
- Nail ridging in Pfizer BioNTech Covid Vaccine
- Nail ridging in Johnson and Johnson Covid Vaccine
All the drugs that are associated with Nail ridging:
- Nail ridging (422 drugs)
All the conditions that are associated with Nail ridging:
- Nail ridging (280 conditions)
How the study uses the data?
The study uses data from the FDA. It is based on tofacitinib citrate (the active ingredients of Xeljanz) and Xeljanz (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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